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Protein

WD repeat domain-containing protein 83

Gene

wdr83

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain-containing protein 83
Alternative name(s):
Mitogen-activated protein kinase organizer 1
Short name:
MAPK organizer 1
Gene namesi
Name:wdr83
Synonyms:morg1
ORF Names:zgc:92654
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040718-126. wdr83.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315WD repeat domain-containing protein 83PRO_0000235266Add
BLAST

Proteomic databases

PaxDbiQ6DH44.
PRIDEiQ6DH44.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000060977.

Structurei

3D structure databases

ProteinModelPortaliQ6DH44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 6240WD 1Add
BLAST
Repeati65 – 10440WD 2Add
BLAST
Repeati107 – 14640WD 3Add
BLAST
Repeati151 – 18838WD 4Add
BLAST
Repeati189 – 22840WD 5Add
BLAST
Repeati233 – 27240WD 6Add
BLAST
Repeati275 – 31339WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat MORG1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0316. Eukaryota.
ENOG410XRZ0. LUCA.
HOGENOMiHOG000091642.
HOVERGENiHBG105288.
InParanoidiQ6DH44.
KOiK13124.
PhylomeDBiQ6DH44.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DH44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFPQPRPQA PQLPQHLWRT VDCQQGAVRA VRFNADGNYL LTCGSDKSLK
60 70 80 90 100
LWSVSRGTLL KTYSGHGYEV LDADGSYDNS QLCSCSSDKT VILWDVASGQ
110 120 130 140 150
VTRKLRGHAG KVNCVQFNEE ATVMLSGSID GTVRCWDTRS RRMEPIQILD
160 170 180 190 200
ESQDGISSLK VSEHELLTGS VDGRVRRYDL RMGQLQVDYI GSPITCVCFS
210 220 230 240 250
RDGQCTLSSS LDSTVRLLDK STGEMLGEYS GHVNKGYKLD CCLTDKDTHV
260 270 280 290 300
LSCSEDGHVY YWDLVEGSLT LKLPVGKAVV QSLSFHPTEP RLLTSMEGRV
310
QVWGAEPEDA AENES
Length:315
Mass (Da):34,795
Last modified:August 16, 2004 - v1
Checksum:i1578D04EFF728921
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076138 mRNA. Translation: AAH76138.1.
RefSeqiNP_001002429.1. NM_001002429.1.
UniGeneiDr.80944.

Genome annotation databases

GeneIDi436702.
KEGGidre:436702.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076138 mRNA. Translation: AAH76138.1.
RefSeqiNP_001002429.1. NM_001002429.1.
UniGeneiDr.80944.

3D structure databases

ProteinModelPortaliQ6DH44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000060977.

Proteomic databases

PaxDbiQ6DH44.
PRIDEiQ6DH44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi436702.
KEGGidre:436702.

Organism-specific databases

CTDi84292.
ZFINiZDB-GENE-040718-126. wdr83.

Phylogenomic databases

eggNOGiKOG0316. Eukaryota.
ENOG410XRZ0. LUCA.
HOGENOMiHOG000091642.
HOVERGENiHBG105288.
InParanoidiQ6DH44.
KOiK13124.
PhylomeDBiQ6DH44.

Miscellaneous databases

NextBioi20831145.
PROiQ6DH44.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiWDR83_DANRE
AccessioniPrimary (citable) accession number: Q6DH44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: August 16, 2004
Last modified: November 11, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.