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Protein
Submitted name:

Glutaredoxin 2

Gene

glrx2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Glutaredoxin 2Imported
Gene namesi
Name:glrx2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040718-101. glrx2.

Expressioni

Gene expression databases

BgeeiQ6DH06.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062536.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UIWX-ray2.60A/B1-134[»]
ProteinModelPortaliQ6DH06.
SMRiQ6DH06. Positions 7-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0695.
HOGENOMiHOG000095204.
HOVERGENiHBG096801.
KOiK03676.
PhylomeDBiQ6DH06.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DH06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNFSSSAPG LSSSACGQFV QDIVSSNCVV IFSKTTCPYC KMAKGVFNEI
60 70 80 90 100
GATYKVVELD EHNDGRRLQE TLAELTGART VPRVFINGQC IGGGSDTKQL
110 120 130
HQQGKLLPLI EQCRPCCLNM TPEGSGNSQN QPHQ
Length:134
Mass (Da):14,408
Last modified:August 16, 2004 - v1
Checksum:iDBF98B30628DA0BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076178 mRNA. Translation: AAH76178.1.
RefSeqiNP_001002404.1. NM_001002404.1.
XP_009294644.1. XM_009296369.1.
UniGeneiDr.88731.

Genome annotation databases

GeneIDi436677.
KEGGidre:436677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076178 mRNA. Translation: AAH76178.1.
RefSeqiNP_001002404.1. NM_001002404.1.
XP_009294644.1. XM_009296369.1.
UniGeneiDr.88731.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UIWX-ray2.60A/B1-134[»]
ProteinModelPortaliQ6DH06.
SMRiQ6DH06. Positions 7-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi436677.
KEGGidre:436677.

Organism-specific databases

CTDi51022.
ZFINiZDB-GENE-040718-101. glrx2.

Phylogenomic databases

eggNOGiCOG0695.
HOGENOMiHOG000095204.
HOVERGENiHBG096801.
KOiK03676.
PhylomeDBiQ6DH06.

Miscellaneous databases

NextBioi20831120.

Gene expression databases

BgeeiQ6DH06.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EyeImported.
  2. "A New Mode of Iron-sulfur Cluster Coordination in Glutaredoxins is Crucial for Axonogenesis."
    Brautigam L., Johansson C., Kubsch B., McDonough M.A., Bill E., Holmgren A., Berndt C.
    Submitted (OCT-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE, ACTIVE SITE.

Entry informationi

Entry nameiQ6DH06_DANRE
AccessioniPrimary (citable) accession number: Q6DH06
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: April 1, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.