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Q6DH06

- Q6DH06_DANRE

UniProt

Q6DH06 - Q6DH06_DANRE

Protein
Submitted name:

Glutaredoxin 2

Gene

glrx2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei69 – 691GlutathioneImported
    Binding sitei81 – 811Glutathione; via amide nitrogen and carbonyl oxygenImported

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. protein disulfide oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. cell redox homeostasis Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glutaredoxin 2Imported
    Gene namesi
    Name:glrx2Imported
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

    Organism-specific databases

    ZFINiZDB-GENE-040718-101. glrx2.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000062536.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3UIWX-ray2.60A/B1-134[»]
    ProteinModelPortaliQ6DH06.
    SMRiQ6DH06. Positions 7-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni34 – 396Glutathione bindingImported
    Regioni94 – 952Glutathione bindingImported

    Phylogenomic databases

    eggNOGiCOG0695.
    HOGENOMiHOG000095204.
    HOVERGENiHBG096801.
    InParanoidiQ6DH06.
    KOiK03676.
    PhylomeDBiQ6DH06.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR011767. GLR_AS.
    IPR002109. Glutaredoxin.
    IPR011899. Glutaredoxin_euk/vir.
    IPR014025. Glutaredoxin_subgr.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF00462. Glutaredoxin. 1 hit.
    [Graphical view]
    PRINTSiPR00160. GLUTAREDOXIN.
    SUPFAMiSSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
    PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
    PS51354. GLUTAREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DH06-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNFSSSAPG LSSSACGQFV QDIVSSNCVV IFSKTTCPYC KMAKGVFNEI    50
    GATYKVVELD EHNDGRRLQE TLAELTGART VPRVFINGQC IGGGSDTKQL 100
    HQQGKLLPLI EQCRPCCLNM TPEGSGNSQN QPHQ 134
    Length:134
    Mass (Da):14,408
    Last modified:August 16, 2004 - v1
    Checksum:iDBF98B30628DA0BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC076178 mRNA. Translation: AAH76178.1.
    RefSeqiNP_001002404.1. NM_001002404.1.
    UniGeneiDr.88731.

    Genome annotation databases

    GeneIDi436677.
    KEGGidre:436677.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC076178 mRNA. Translation: AAH76178.1 .
    RefSeqi NP_001002404.1. NM_001002404.1.
    UniGenei Dr.88731.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3UIW X-ray 2.60 A/B 1-134 [» ]
    ProteinModelPortali Q6DH06.
    SMRi Q6DH06. Positions 7-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000062536.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 436677.
    KEGGi dre:436677.

    Organism-specific databases

    CTDi 51022.
    ZFINi ZDB-GENE-040718-101. glrx2.

    Phylogenomic databases

    eggNOGi COG0695.
    HOGENOMi HOG000095204.
    HOVERGENi HBG096801.
    InParanoidi Q6DH06.
    KOi K03676.
    PhylomeDBi Q6DH06.

    Miscellaneous databases

    NextBioi 20831120.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR011767. GLR_AS.
    IPR002109. Glutaredoxin.
    IPR011899. Glutaredoxin_euk/vir.
    IPR014025. Glutaredoxin_subgr.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF00462. Glutaredoxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00160. GLUTAREDOXIN.
    SUPFAMi SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR02180. GRX_euk. 1 hit.
    PROSITEi PS00195. GLUTAREDOXIN_1. 1 hit.
    PS51354. GLUTAREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EyeImported.
    2. "A New Mode of Iron-sulfur Cluster Coordination in Glutaredoxins is Crucial for Axonogenesis."
      Brautigam L., Johansson C., Kubsch B., McDonough M.A., Bill E., Holmgren A., Berndt C.
      Submitted (NOV-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.

    Entry informationi

    Entry nameiQ6DH06_DANRE
    AccessioniPrimary (citable) accession number: Q6DH06
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3