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Protein
Submitted name:

Glutaredoxin 2

Gene

glrx2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69GlutathioneCombined sources1
Binding sitei81Glutathione; via amide nitrogen and carbonyl oxygenCombined sources1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • central nervous system development Source: ZFIN
  • heart formation Source: ZFIN
  • neural crest cell migration Source: ZFIN
  • neural crest cell migration involved in heart formation Source: ZFIN
  • protein deglutathionylation Source: ZFIN
  • vasculature development Source: ZFIN

Names & Taxonomyi

Protein namesi
Submitted name:
Glutaredoxin 2Imported
Gene namesi
Name:glrx2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040718-101. glrx2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 113Combined sources
Disulfide bondi116Combined sources

Proteomic databases

PaxDbiQ6DH06.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UIWX-ray2.60A/B1-134[»]
ProteinModelPortaliQ6DH06.
SMRiQ6DH06.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 117GlutaredoxinInterPro annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 39Glutathione bindingCombined sources6
Regioni94 – 95Glutathione bindingCombined sources2

Phylogenomic databases

eggNOGiKOG1752. Eukaryota.
COG0695. LUCA.
HOGENOMiHOG000095204.
HOVERGENiHBG096801.
PhylomeDBiQ6DH06.

Family and domain databases

InterProiView protein in InterPro
IPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR036249. Thioredoxin-like_sf.
PfamiView protein in Pfam
PF00462. Glutaredoxin. 1 hit.
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DH06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNFSSSAPG LSSSACGQFV QDIVSSNCVV IFSKTTCPYC KMAKGVFNEI
60 70 80 90 100
GATYKVVELD EHNDGRRLQE TLAELTGART VPRVFINGQC IGGGSDTKQL
110 120 130
HQQGKLLPLI EQCRPCCLNM TPEGSGNSQN QPHQ
Length:134
Mass (Da):14,408
Last modified:August 16, 2004 - v1
Checksum:iDBF98B30628DA0BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076178 mRNA. Translation: AAH76178.1.
RefSeqiNP_001002404.1. NM_001002404.1.
XP_009294644.1. XM_009296369.2.
UniGeneiDr.88731.

Genome annotation databases

GeneIDi436677.

Similar proteinsi

Entry informationi

Entry nameiQ6DH06_DANRE
AccessioniPrimary (citable) accession number: Q6DH06
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 22, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources