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Protein
Submitted name:

Glutaredoxin 2

Gene

glrx2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69GlutathioneCombined sources1
Binding sitei81Glutathione; via amide nitrogen and carbonyl oxygenCombined sources1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • central nervous system development Source: ZFIN
  • heart formation Source: ZFIN
  • neural crest cell migration Source: ZFIN
  • neural crest cell migration involved in heart formation Source: ZFIN
  • protein deglutathionylation Source: ZFIN
  • vasculature development Source: ZFIN

Names & Taxonomyi

Protein namesi
Submitted name:
Glutaredoxin 2Imported
Gene namesi
Name:glrx2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040718-101 glrx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 113Combined sources
Disulfide bondi116Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UIWX-ray2.60A/B1-134[»]
ProteinModelPortaliQ6DH06
SMRiQ6DH06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 117GlutaredoxinInterPro annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 39Glutathione bindingCombined sources6
Regioni94 – 95Glutathione bindingCombined sources2

Phylogenomic databases

eggNOGiKOG1752 Eukaryota
COG0695 LUCA
HOGENOMiHOG000095204
HOVERGENiHBG096801
KOiK03676
PhylomeDBiQ6DH06

Family and domain databases

InterProiView protein in InterPro
IPR011767 GLR_AS
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR014025 Glutaredoxin_subgr
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02180 GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS00195 GLUTAREDOXIN_1, 1 hit
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DH06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNFSSSAPG LSSSACGQFV QDIVSSNCVV IFSKTTCPYC KMAKGVFNEI
60 70 80 90 100
GATYKVVELD EHNDGRRLQE TLAELTGART VPRVFINGQC IGGGSDTKQL
110 120 130
HQQGKLLPLI EQCRPCCLNM TPEGSGNSQN QPHQ
Length:134
Mass (Da):14,408
Last modified:August 16, 2004 - v1
Checksum:iDBF98B30628DA0BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076178 mRNA Translation: AAH76178.1
RefSeqiNP_001002404.1, NM_001002404.1
XP_009294644.1, XM_009296369.2
UniGeneiDr.88731

Genome annotation databases

GeneIDi436677
KEGGidre:436677

Similar proteinsi

Entry informationi

Entry nameiQ6DH06_DANRE
AccessioniPrimary (citable) accession number: Q6DH06
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: February 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources