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Q6DH06

- Q6DH06_DANRE

UniProt

Q6DH06 - Q6DH06_DANRE

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Protein
Submitted name:

Glutaredoxin 2

Gene

glrx2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691GlutathioneImported
Binding sitei81 – 811Glutathione; via amide nitrogen and carbonyl oxygenImported

GO - Molecular functioni

  1. electron carrier activity Source: InterPro
  2. protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  1. cell redox homeostasis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Glutaredoxin 2Imported
Gene namesi
Name:glrx2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-040718-101. glrx2.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062536.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UIWX-ray2.60A/B1-134[»]
ProteinModelPortaliQ6DH06.
SMRiQ6DH06. Positions 7-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni34 – 396Glutathione bindingImported
Regioni94 – 952Glutathione bindingImported

Phylogenomic databases

eggNOGiCOG0695.
HOGENOMiHOG000095204.
HOVERGENiHBG096801.
KOiK03676.
PhylomeDBiQ6DH06.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00462. Glutaredoxin. 1 hit.
[Graphical view]
PRINTSiPR00160. GLUTAREDOXIN.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR02180. GRX_euk. 1 hit.
PROSITEiPS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DH06-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNFSSSAPG LSSSACGQFV QDIVSSNCVV IFSKTTCPYC KMAKGVFNEI
60 70 80 90 100
GATYKVVELD EHNDGRRLQE TLAELTGART VPRVFINGQC IGGGSDTKQL
110 120 130
HQQGKLLPLI EQCRPCCLNM TPEGSGNSQN QPHQ
Length:134
Mass (Da):14,408
Last modified:August 16, 2004 - v1
Checksum:iDBF98B30628DA0BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC076178 mRNA. Translation: AAH76178.1.
RefSeqiNP_001002404.1. NM_001002404.1.
UniGeneiDr.88731.

Genome annotation databases

GeneIDi436677.
KEGGidre:436677.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC076178 mRNA. Translation: AAH76178.1 .
RefSeqi NP_001002404.1. NM_001002404.1.
UniGenei Dr.88731.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UIW X-ray 2.60 A/B 1-134 [» ]
ProteinModelPortali Q6DH06.
SMRi Q6DH06. Positions 7-114.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000062536.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 436677.
KEGGi dre:436677.

Organism-specific databases

CTDi 51022.
ZFINi ZDB-GENE-040718-101. glrx2.

Phylogenomic databases

eggNOGi COG0695.
HOGENOMi HOG000095204.
HOVERGENi HBG096801.
KOi K03676.
PhylomeDBi Q6DH06.

Miscellaneous databases

NextBioi 20831120.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR011767. GLR_AS.
IPR002109. Glutaredoxin.
IPR011899. Glutaredoxin_euk/vir.
IPR014025. Glutaredoxin_subgr.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00462. Glutaredoxin. 1 hit.
[Graphical view ]
PRINTSi PR00160. GLUTAREDOXIN.
SUPFAMi SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR02180. GRX_euk. 1 hit.
PROSITEi PS00195. GLUTAREDOXIN_1. 1 hit.
PS51354. GLUTAREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EyeImported.
  2. "A New Mode of Iron-sulfur Cluster Coordination in Glutaredoxins is Crucial for Axonogenesis."
    Brautigam L., Johansson C., Kubsch B., McDonough M.A., Bill E., Holmgren A., Berndt C.
    Submitted (NOV-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE.

Entry informationi

Entry nameiQ6DH06_DANRE
AccessioniPrimary (citable) accession number: Q6DH06
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3