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Protein

Solute carrier family 25 member 46

Gene

slc25a46

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission.By similarity

GO - Biological processi

  • axon development Source: ZFIN
  • mitochondrial fission Source: ZFIN
  • mitochondrial membrane fission Source: UniProtKB
  • neuron projection development Source: ZFIN
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 46
Gene namesi
Name:slc25a46
ORF Names:si:ch211-220b11.2, zgc:92767
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-040718-296. slc25a46.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei87 – 10721Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei183 – 20321Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei371 – 39121Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrial outer membrane Source: UniProtKB
  • neuron projection Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Disruption phenotypei

Morpholino knockdown have a curly tail morphology and impaired swimming, suggesting dysfunction of neural circuits. Spinal motor neurons have shortened axon tracts due to degeneration of neuronal processes. Mitochondria in the degenerating motor neurons show incomplete fission, abnormal aggregation and abnormal cell localization compared to wild-type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 405405Solute carrier family 25 member 46PRO_0000291832Add
BLAST

Proteomic databases

PaxDbiQ6DGU5.
PRIDEiQ6DGU5.

Expressioni

Gene expression databases

BgeeiQ6DGU5.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000050965.

Structurei

3D structure databases

ProteinModelPortaliQ6DGU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati80 – 17192Solcar 1Add
BLAST
Repeati299 – 401103Solcar 2Add
BLAST

Sequence similaritiesi

Contains 2 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2954. Eukaryota.
ENOG410XRFB. LUCA.
GeneTreeiENSGT00390000015874.
HOGENOMiHOG000007981.
HOVERGENiHBG059752.
InParanoidiQ6DGU5.
KOiK03454.
OMAiAHPCIVF.
OrthoDBiEOG7MPRDV.
PhylomeDBiQ6DGU5.
TreeFamiTF313365.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DGU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRRPDSFE GLGYRGREDP AFSGGYSGRS FNNSSSSDLQ NWVTTPPDIP
60 70 80 90 100
GSRNLHFDDR TPQFETAPDE AQSAAPPSEQ LNRFAGFGIG LASLFTENVL
110 120 130 140 150
AHPCIVFRRQ CQVNYHARCY HLSPMTAISV MYNVTKTQGP KALWKGMGST
160 170 180 190 200
FVVQGVTLGT EGIISECTPL PRELSHKWNP KQVVGHLVLK GLTYVVAMPF
210 220 230 240 250
YSASLIETVQ SEIIRDNPGI LDCVKEGLGR VMGMGIPHSK RLLPLWNLVL
260 270 280 290 300
PTVLHGILHY IISSSIQRLV LYLLRRRNNG SPKHSSPGSG MDTVQSMLDA
310 320 330 340 350
YFPELMASFA ASLCADVLLF PLETVLHRLH IQGTRTIIDN TDLGFEVLPI
360 370 380 390 400
NTQYEGMRDC INAIRREEGT MGFYKGFGSI VVQYSLHATV LQITKMIYST

LLRNA
Length:405
Mass (Da):44,910
Last modified:August 16, 2004 - v1
Checksum:i13F1CC56258A584D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT027584, BX294395 Genomic DNA. Translation: CAM14355.1.
BX294395, CT027584 Genomic DNA. Translation: CAM56400.1.
BC076244 mRNA. Translation: AAH76244.1.
RefSeqiNP_001002558.1. NM_001002558.1.
UniGeneiDr.85416.

Genome annotation databases

EnsembliENSDART00000050966; ENSDARP00000050965; ENSDARG00000035181.
GeneIDi436831.
KEGGidre:436831.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT027584, BX294395 Genomic DNA. Translation: CAM14355.1.
BX294395, CT027584 Genomic DNA. Translation: CAM56400.1.
BC076244 mRNA. Translation: AAH76244.1.
RefSeqiNP_001002558.1. NM_001002558.1.
UniGeneiDr.85416.

3D structure databases

ProteinModelPortaliQ6DGU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000050965.

Proteomic databases

PaxDbiQ6DGU5.
PRIDEiQ6DGU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000050966; ENSDARP00000050965; ENSDARG00000035181.
GeneIDi436831.
KEGGidre:436831.

Organism-specific databases

CTDi91137.
ZFINiZDB-GENE-040718-296. slc25a46.

Phylogenomic databases

eggNOGiKOG2954. Eukaryota.
ENOG410XRFB. LUCA.
GeneTreeiENSGT00390000015874.
HOGENOMiHOG000007981.
HOVERGENiHBG059752.
InParanoidiQ6DGU5.
KOiK03454.
OMAiAHPCIVF.
OrthoDBiEOG7MPRDV.
PhylomeDBiQ6DGU5.
TreeFamiTF313365.

Miscellaneous databases

PROiQ6DGU5.

Gene expression databases

BgeeiQ6DGU5.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 1 hit.
[Graphical view]
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiS2546_DANRE
AccessioniPrimary (citable) accession number: Q6DGU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.