Reviewed,
UniProtKB/Swiss-Prot Q6DGS3 (KC2D2_DANRE)
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September 1, 2009.
Version 54.
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Calcium/calmodulin-dependent protein kinase type II delta 2 chain EC=2.7.11.17 Alternative name(s): Calcium/calmodulin-dependent protein kinase type II delta-A chain Short name=CaM-kinase II delta-A chain Short name=CaM kinase II subunit delta-A Short name=CaMK-II subunit delta-A | ||||||
| Gene names |
| ||||||
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) | ||||||
| Taxonomic identifier | 7955 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Protein attributes
| Sequence length | 554 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Enzyme regulation | Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity By similarity. |
| Subunit structure | CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits By similarity. |
| Tissue specificity | First detected at 18 hpf. At 24 hpf, expressed in discrete anterior locations and along either side of the midline. At 48 hpf, expression is predominantly in the forebrain, and then accumulates in the forebrain, hindbrain, and retinal epithelium at 72 hpf. Ref.2 |
| Sequence similarities | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing |
| Ligand | ATP-binding Calmodulin-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calmodulin bindingInferred from electronic annotation. Source: UniProtKB-KW calmodulin-dependent protein kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform O (identifier: Q6DGS3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform A (identifier: Q6DGS3-2) The sequence of this isoform differs from the canonical sequence as follows: 379-419: Missing. | ||||||
| Isoform E (identifier: Q6DGS3-3) The sequence of this isoform differs from the canonical sequence as follows: 329-348: Missing. 379-419: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 554 | 554 | Calcium/calmodulin-dependent protein kinase type II delta 2 chain | PRO_0000277821 | |||||
Regions | |||||||||
| Domain | 13 – 271 | 259 | Protein kinase | ||||||
| Nucleotide binding | 19 – 27 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 135 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 42 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 286 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 314 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 318 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 372 | 1 | Phosphothreonine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 329 – 348 | 20 | Missing in isoform E. | VSP_035556 | |||||
| Alternative sequence | 379 – 419 | 41 | Missing in isoform A and isoform E. | VSP_035557 | |||||
Experimental info | |||||||||
| Sequence conflict | 266 | 1 | P → L in AAI54769. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | NIH - Zebrafish Gene Collection (ZGC) project Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM E). Tissue: Brain and Embryo. |
| [2] | "Differential expression of CaMK-II genes during early zebrafish embryogenesis." Rothschild S.C., Lister J.A., Tombes R.M. Dev. Dyn. 236:295-305(2007) [PubMed: 17103413] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 301-446 (ISOFORMS A; E AND O), ALTERNATIVE SPLICING, TISSUE SPECIFICITY. |
Cross-references
Sequence databases | |
|---|---|
| BC076266 mRNA. Translation: AAH76266.1. BC154768 mRNA. Translation: AAI54769.1. | |
| IPI | IPI00501360. IPI00769327. IPI00914344. |
| RefSeq | NP_001002542.1. |
| UniGene | Dr.84611 |
3D structure databases | |
| SMR | Q6DGS3. Positions 7-314, 351-487. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSDART00000044896; ENSDARP00000044895; ENSDARG00000014273; Danio rerio. [Genome view] |
| GeneID | 436815. |
| KEGG | dre:436815. |
Organism-specific databases | |
| CTD | 436815. |
| ZFIN | ZDB-GENE-040718-277. camk2d2. |
Phylogenomic databases | |
| HOVERGEN | Q6DGS3. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.17. 96826. |
Gene expression databases | |
| ArrayExpress | Q6DGS3. |
| Bgee | Q6DGS3. |
Family and domain databases | |
| InterPro | IPR013543. Ca/calmodulin-dep_kinase-assoc. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view] |
| Pfam | PF08332. CaMKII_AD. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KC2D2_DANRE | ||||||||
| Accession | Primary (citable) accession number: Q6DGS3 Secondary accession number(s): A8WGM2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Zebrafish annotation project | ||||||||
