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Protein

NF-kappa-B inhibitor-interacting Ras-like protein 1

Gene

nkiras1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188GTPBy similarity
Nucleotide bindingi61 – 655GTPBy similarity
Nucleotide bindingi120 – 1234GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NF-kappa-B inhibitor-interacting Ras-like protein 1
Alternative name(s):
I-kappa-B-interacting Ras-like protein 1
Short name:
Kappa B-Ras protein 1
Short name:
KappaB-Ras1
Gene namesi
Name:nkiras1
ORF Names:si:dkey-126a1.3, zgc:92823
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-040718-215. nkiras1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 192192NF-kappa-B inhibitor-interacting Ras-like protein 1PRO_0000225678Add
BLAST

Proteomic databases

PaxDbiQ6DGQ1.

Expressioni

Gene expression databases

BgeeiENSDARG00000033548.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043219.

Structurei

3D structure databases

ProteinModelPortaliQ6DGQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 192192Small GTPase-likeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector region

Domaini

In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this family are clearly different from other small GTPases proteins.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3883. Eukaryota.
ENOG4110VES. LUCA.
GeneTreeiENSGT00390000006495.
HOGENOMiHOG000230991.
HOVERGENiHBG105089.
InParanoidiQ6DGQ1.
KOiK17197.
PhylomeDBiQ6DGQ1.
TreeFamiTF314483.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DGQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGCKVVVC GMASVGKTAI LEQLLYGSHT VGAETSDTQE DIYVASVETD
60 70 80 90 100
RGVREQLRLY DTRGLREGLD LPKHFFSVAD GFVLVYSVDC LESFKKVEVL
110 120 130 140 150
KKEIDRSRDK KEVMVMVLGN KCELRERRQV DQDTAQQWAR GEKVKLWEVT
160 170 180 190
VTDRSTLIEP FTSLTSRLTQ PQSKSAFPLP GRKSKGTPSN DI
Length:192
Mass (Da):21,546
Last modified:March 24, 2009 - v2
Checksum:i800040B9E0A15CDF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701D → G in AAH76289 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927163 Genomic DNA. Translation: CAN87987.1.
BC076289 mRNA. Translation: AAH76289.1.
RefSeqiNP_001093546.1. NM_001100076.1.
UniGeneiDr.79630.

Genome annotation databases

EnsembliENSDART00000162383; ENSDARP00000135507; ENSDARG00000099527.
GeneIDi100002175.
KEGGidre:100002175.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX927163 Genomic DNA. Translation: CAN87987.1.
BC076289 mRNA. Translation: AAH76289.1.
RefSeqiNP_001093546.1. NM_001100076.1.
UniGeneiDr.79630.

3D structure databases

ProteinModelPortaliQ6DGQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000043219.

Proteomic databases

PaxDbiQ6DGQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000162383; ENSDARP00000135507; ENSDARG00000099527.
GeneIDi100002175.
KEGGidre:100002175.

Organism-specific databases

CTDi28512.
ZFINiZDB-GENE-040718-215. nkiras1.

Phylogenomic databases

eggNOGiKOG3883. Eukaryota.
ENOG4110VES. LUCA.
GeneTreeiENSGT00390000006495.
HOGENOMiHOG000230991.
HOVERGENiHBG105089.
InParanoidiQ6DGQ1.
KOiK17197.
PhylomeDBiQ6DGQ1.
TreeFamiTF314483.

Miscellaneous databases

PROiQ6DGQ1.

Gene expression databases

BgeeiENSDARG00000033548.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKBRS1_DANRE
AccessioniPrimary (citable) accession number: Q6DGQ1
Secondary accession number(s): A5PMZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 24, 2009
Last modified: September 7, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.