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Protein

Transcription elongation factor SPT4

Gene

supt4h1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 36C4-typeSequence analysisAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor SPT4
Alternative name(s):
DRB sensitivity-inducing factor small subunit
Short name:
DSIF small subunit
Gene namesi
Name:supt4h1
ORF Names:zgc:92824
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040718-214 supt4h1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002103301 – 117Transcription elongation factor SPT4Add BLAST117

Proteomic databases

PaxDbiQ6DGQ0

Interactioni

Subunit structurei

Interacts with SUPT5H to form the DSIF complex. DSIF interacts with RNA polymerase II and with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000048842

Structurei

3D structure databases

ProteinModelPortaliQ6DGQ0
SMRiQ6DGQ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 40Interaction with SUPT5HBy similarityAdd BLAST40

Sequence similaritiesi

Belongs to the SPT4 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri16 – 36C4-typeSequence analysisAdd BLAST21

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3490 Eukaryota
COG5204 LUCA
GeneTreeiENSGT00390000018559
HOGENOMiHOG000172685
HOVERGENiHBG055988
InParanoidiQ6DGQ0
KOiK15171
PhylomeDBiQ6DGQ0
TreeFamiTF300105

Family and domain databases

CDDicd07973 Spt4, 1 hit
Gene3Di3.30.40.210, 1 hit
InterProiView protein in InterPro
IPR029040 RPABC4/Spt4
IPR009287 Spt4
IPR022800 Spt4/RpoE2_Znf
IPR038510 Spt4_sf
PANTHERiPTHR12882 PTHR12882, 1 hit
PfamiView protein in Pfam
PF06093 Spt4, 1 hit
PIRSFiPIRSF025023 Spt4, 1 hit
SMARTiView protein in SMART
SM01389 Spt4, 1 hit
SUPFAMiSSF63393 SSF63393, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DGQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLETVPKDL RHLRACLLCS LVKTIDQFEY DGCDNCESYL QMKGNREMVY
60 70 80 90 100
ECTSSSFDGV IAMMSPEDSW VAKWQRIGNF KPGVYAVTVT GRLPPGVVRE
110
LKSRGVIYRS RDTAVKT
Length:117
Mass (Da):13,232
Last modified:August 16, 2004 - v1
Checksum:iAE6B05FE2DD4D9CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076290 mRNA Translation: AAH76290.1
RefSeqiNP_001002509.1, NM_001002509.1
UniGeneiDr.79365

Genome annotation databases

EnsembliENSDART00000179809; ENSDARP00000147232; ENSDARG00000113969
GeneIDi436782
KEGGidre:436782

Similar proteinsi

Entry informationi

Entry nameiSPT4H_DANRE
AccessioniPrimary (citable) accession number: Q6DGQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 16, 2004
Last modified: June 20, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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