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Protein

Transcription elongation factor SPT4

Gene

supt4h1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 3621C4-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor SPT4
Alternative name(s):
DRB sensitivity-inducing factor small subunit
Short name:
DSIF small subunit
Gene namesi
Name:supt4h1
ORF Names:zgc:92824
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040718-214. supt4h1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 117117Transcription elongation factor SPT4PRO_0000210330Add
BLAST

Proteomic databases

PaxDbiQ6DGQ0.
PRIDEiQ6DGQ0.

Expressioni

Gene expression databases

BgeeiQ6DGQ0.

Interactioni

Subunit structurei

Interacts with SUPT5H to form the DSIF complex. DSIF interacts with RNA polymerase II and with the positive transcription elongation factor b complex (P-TEFb complex), which is composed of CDK9 and cyclin-T (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000048842.

Structurei

3D structure databases

ProteinModelPortaliQ6DGQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 4040Interaction with SUPT5HBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SPT4 family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri16 – 3621C4-typeSequence analysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3490. Eukaryota.
COG5204. LUCA.
HOGENOMiHOG000172685.
HOVERGENiHBG055988.
InParanoidiQ6DGQ0.
KOiK15171.
OrthoDBiEOG7RFTK7.
PhylomeDBiQ6DGQ0.
TreeFamiTF300105.

Family and domain databases

InterProiIPR029040. RPABC4/Spt4.
IPR009287. Spt4.
IPR016046. Spt4-like.
IPR022800. Spt4/RpoE2_Znf.
[Graphical view]
PANTHERiPTHR12882. PTHR12882. 1 hit.
PfamiPF06093. Spt4. 1 hit.
[Graphical view]
PIRSFiPIRSF025023. Spt4. 1 hit.
SMARTiSM01389. Spt4. 1 hit.
[Graphical view]
SUPFAMiSSF63393. SSF63393. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DGQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLETVPKDL RHLRACLLCS LVKTIDQFEY DGCDNCESYL QMKGNREMVY
60 70 80 90 100
ECTSSSFDGV IAMMSPEDSW VAKWQRIGNF KPGVYAVTVT GRLPPGVVRE
110
LKSRGVIYRS RDTAVKT
Length:117
Mass (Da):13,232
Last modified:August 16, 2004 - v1
Checksum:iAE6B05FE2DD4D9CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076290 mRNA. Translation: AAH76290.1.
RefSeqiNP_001002509.1. NM_001002509.1.
UniGeneiDr.79365.

Genome annotation databases

GeneIDi436782.
KEGGidre:436782.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076290 mRNA. Translation: AAH76290.1.
RefSeqiNP_001002509.1. NM_001002509.1.
UniGeneiDr.79365.

3D structure databases

ProteinModelPortaliQ6DGQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000048842.

Proteomic databases

PaxDbiQ6DGQ0.
PRIDEiQ6DGQ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi436782.
KEGGidre:436782.

Organism-specific databases

CTDi6827.
ZFINiZDB-GENE-040718-214. supt4h1.

Phylogenomic databases

eggNOGiKOG3490. Eukaryota.
COG5204. LUCA.
HOGENOMiHOG000172685.
HOVERGENiHBG055988.
InParanoidiQ6DGQ0.
KOiK15171.
OrthoDBiEOG7RFTK7.
PhylomeDBiQ6DGQ0.
TreeFamiTF300105.

Miscellaneous databases

PROiQ6DGQ0.

Gene expression databases

BgeeiQ6DGQ0.

Family and domain databases

InterProiIPR029040. RPABC4/Spt4.
IPR009287. Spt4.
IPR016046. Spt4-like.
IPR022800. Spt4/RpoE2_Znf.
[Graphical view]
PANTHERiPTHR12882. PTHR12882. 1 hit.
PfamiPF06093. Spt4. 1 hit.
[Graphical view]
PIRSFiPIRSF025023. Spt4. 1 hit.
SMARTiSM01389. Spt4. 1 hit.
[Graphical view]
SUPFAMiSSF63393. SSF63393. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiSPT4H_DANRE
AccessioniPrimary (citable) accession number: Q6DGQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.