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Protein

L-lactate dehydrogenase B-B chain

Gene

ldhbb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.By similarity

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldha), L-lactate dehydrogenase B-A chain (ldhba), L-lactate dehydrogenase (ldhbb), L-lactate dehydrogenase A chain (ldha), L-lactate dehydrogenase B-B chain (ldhbb)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001NADBy similarity
Binding sitei107 – 1071SubstrateBy similarity
Binding sitei139 – 1391NAD or substrateBy similarity
Binding sitei170 – 1701SubstrateBy similarity
Active sitei194 – 1941Proton acceptorBy similarity
Binding sitei249 – 2491SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 5829NADBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-DRE-70268. Pyruvate metabolism.
UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase B-B chainBy similarity (EC:1.1.1.27)
Short name:
LDH-B-BBy similarity
Gene namesi
Name:ldhbbImported
ORF Names:zgc:92882
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 25

Organism-specific databases

ZFINiZDB-GENE-040718-176. ldhbb.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 334333L-lactate dehydrogenase B-B chainBy similarityPRO_0000401128Add
BLAST

Proteomic databases

PRIDEiQ6DGK2.

Expressioni

Gene expression databases

BgeeiENSDARG00000071076.
ExpressionAtlasiQ6DGK2. differential.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6DGK2.
SMRiQ6DGK2. Positions 2-333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Sequence analysis

Phylogenomic databases

GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
InParanoidiQ6DGK2.
KOiK00016.
OMAiCNDKLQG.
OrthoDBiEOG091G0HME.
PhylomeDBiQ6DGK2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6DGK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLQKLIT PLFSGPLEPP RNKVTVVGVG QVGMACAVSV LLRELADELA
60 70 80 90 100
LVDVVEDKLK GEMMDLQHGS LFLKTPKIVS GKDYSVTANS RIVVVTAGVR
110 120 130 140 150
QQEGESRLNL VQRNVNIFKH IIPQIVKYSP NCILIVVSNP VDVLTYVTWK
160 170 180 190 200
LSGLPKHRVI GSGTNLDSAR FRYLMAERLG IHPSSFNGWI LGEHGDSSVP
210 220 230 240 250
VWSGANVAGV SLQKLNPDIG KDTDRENWKE THKKVVDSAY EVIRLKGYTN
260 270 280 290 300
WAIGLSVADL TESIMKNLNR VHPVSTMVKG MYGISDEVYL SLPCVLNSAG
310 320 330
VGSVVNMTLT VDEVSQLKKS ADMLWHIQRD LRDL
Length:334
Mass (Da):36,710
Last modified:August 16, 2004 - v1
Checksum:i86D014E974F98541
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076340 mRNA. Translation: AAH76340.1.
RefSeqiNP_001002474.1. NM_001002474.1.
XP_005170716.1. XM_005170659.2.
UniGeneiDr.108356.

Genome annotation databases

EnsembliENSDART00000104866; ENSDARP00000095636; ENSDARG00000071076.
GeneIDi436747.
KEGGidre:436747.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076340 mRNA. Translation: AAH76340.1.
RefSeqiNP_001002474.1. NM_001002474.1.
XP_005170716.1. XM_005170659.2.
UniGeneiDr.108356.

3D structure databases

ProteinModelPortaliQ6DGK2.
SMRiQ6DGK2. Positions 2-333.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6DGK2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000104866; ENSDARP00000095636; ENSDARG00000071076.
GeneIDi436747.
KEGGidre:436747.

Organism-specific databases

CTDi436747.
ZFINiZDB-GENE-040718-176. ldhbb.

Phylogenomic databases

GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
HOVERGENiHBG000462.
InParanoidiQ6DGK2.
KOiK00016.
OMAiCNDKLQG.
OrthoDBiEOG091G0HME.
PhylomeDBiQ6DGK2.

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.
ReactomeiR-DRE-70268. Pyruvate metabolism.

Miscellaneous databases

PROiQ6DGK2.

Gene expression databases

BgeeiENSDARG00000071076.
ExpressionAtlasiQ6DGK2. differential.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLDHBB_DANRE
AccessioniPrimary (citable) accession number: Q6DGK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: August 16, 2004
Last modified: September 7, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.