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Q6DGG4

- Q6DGG4_RAT

UniProt

Q6DGG4 - Q6DGG4_RAT

Protein

Interferon regulatory factor

Gene

Irf1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. apoptotic process Source: Ensembl
    2. CD8-positive, alpha-beta T cell differentiation Source: Ensembl
    3. cell cycle arrest Source: Ensembl
    4. cellular response to interferon-beta Source: Ensembl
    5. cellular response to mechanical stimulus Source: Ensembl
    6. defense response to virus Source: Ensembl
    7. interferon-gamma-mediated signaling pathway Source: Ensembl
    8. negative regulation of regulatory T cell differentiation Source: Ensembl
    9. positive regulation of interferon-beta production Source: Ensembl
    10. positive regulation of interleukin-12 biosynthetic process Source: Ensembl
    11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. regulation of CD8-positive, alpha-beta T cell proliferation Source: Ensembl
    13. regulation of MyD88-dependent toll-like receptor signaling pathway Source: Ensembl
    14. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    ActivatorUniRule annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Enzyme and pathway databases

    ReactomeiREACT_196232. Factors involved in megakaryocyte development and platelet production.
    REACT_196250. TRAF6 mediated IRF7 activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interferon regulatory factorUniRule annotation
    Gene namesi
    Name:Irf1Imported
    ORF Names:rCG_33161Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi2920. Irf1.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nuclear chromatin Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ6DGG4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IRF family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114956.
    HOVERGENiHBG003455.
    InParanoidiQ6DGG4.
    OMAiCKEEPEV.
    OrthoDBiEOG72ZCFD.
    TreeFamiTF328512.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR017431. Interferon_reg_fac-1/2.
    IPR019817. Interferon_reg_fac_CS.
    IPR001346. Interferon_reg_fact_DNA-bd_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00605. IRF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038196. IFN_RF1/2. 1 hit.
    PRINTSiPR00267. INTFRNREGFCT.
    SMARTiSM00348. IRF. 1 hit.
    [Graphical view]
    PROSITEiPS00601. IRF_1. 1 hit.
    PS51507. IRF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DGG4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPITRMRMRP WLEMQINSNQ IPGLSWINKE EMIFQIPWKH AAKHGWDINK    50
    DACLFRSWAI HTGRYKAGEK EPDPKTWKAN FRCAMNSLPD IEEVKDQSRN 100
    KGSSAVRVYR MLPPLTKNQR KERKSKSSRD TKSKTKRKLC GDSSPDTLSD 150
    GLSSSTLPDD HSSYTAQGYL GQDLDMDRDI TPALSPCVVS SSLSEWHMQM 200
    DIMPDSTTDL YNLQVSPMPS TSEAATDEDE EGKLPEDIMK LFEQSEWQPT 250
    HVDGKGYLLN EPGAQLSTVY GDFSCKEEPE IDSPGGDIEI GIQRVFTEMK 300
    NMDPVMWMDT LLGNSTRPPS IQAIPCAP 328
    Length:328
    Mass (Da):37,080
    Last modified:August 16, 2004 - v1
    Checksum:iEC18398A92747D75
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06063819 Genomic DNA. No translation available.
    BC076382 mRNA. Translation: AAH76382.1.
    CH473948 Genomic DNA. Translation: EDM04397.1.
    CH473948 Genomic DNA. Translation: EDM04399.1.
    CH473948 Genomic DNA. Translation: EDM04401.1.
    UniGeneiRn.6396.

    Genome annotation databases

    EnsembliENSRNOT00000010968; ENSRNOP00000010968; ENSRNOG00000008144.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06063819 Genomic DNA. No translation available.
    BC076382 mRNA. Translation: AAH76382.1 .
    CH473948 Genomic DNA. Translation: EDM04397.1 .
    CH473948 Genomic DNA. Translation: EDM04399.1 .
    CH473948 Genomic DNA. Translation: EDM04401.1 .
    UniGenei Rn.6396.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000010968 ; ENSRNOP00000010968 ; ENSRNOG00000008144 .

    Organism-specific databases

    RGDi 2920. Irf1.

    Phylogenomic databases

    GeneTreei ENSGT00740000114956.
    HOVERGENi HBG003455.
    InParanoidi Q6DGG4.
    OMAi CKEEPEV.
    OrthoDBi EOG72ZCFD.
    TreeFami TF328512.

    Enzyme and pathway databases

    Reactomei REACT_196232. Factors involved in megakaryocyte development and platelet production.
    REACT_196250. TRAF6 mediated IRF7 activation.

    Miscellaneous databases

    PROi Q6DGG4.

    Gene expression databases

    Genevestigatori Q6DGG4.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR017431. Interferon_reg_fac-1/2.
    IPR019817. Interferon_reg_fac_CS.
    IPR001346. Interferon_reg_fact_DNA-bd_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00605. IRF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038196. IFN_RF1/2. 1 hit.
    PRINTSi PR00267. INTFRNREGFCT.
    SMARTi SM00348. IRF. 1 hit.
    [Graphical view ]
    PROSITEi PS00601. IRF_1. 1 hit.
    PS51507. IRF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: LungImported.
    2. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ6DGG4_RAT
    AccessioniPrimary (citable) accession number: Q6DGG4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 16, 2004
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3