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Protein

Protein ABHD14B

Gene

Abhd14b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei111Charge relay systemBy similarity1
Active sitei162Charge relay systemBy similarity1
Active sitei188Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-RNO-156584 Cytosolic sulfonation of small molecules

Protein family/group databases

ESTHERirat-abheb CIB-CCG1-interacting-factor-B

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD14BCurated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 14BCurated
Short name:
Abhydrolase domain-containing protein 14BImported
Gene namesi
Name:Abhd14bImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1359649 Abhd14b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003612801 – 210Protein ABHD14BAdd BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei91PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6DGG1
PRIDEiQ6DGG1

PTM databases

iPTMnetiQ6DGG1
PhosphoSitePlusiQ6DGG1

Expressioni

Gene expression databases

BgeeiENSRNOG00000012073
ExpressionAtlasiQ6DGG1 baseline and differential
GenevisibleiQ6DGG1 RN

Interactioni

Subunit structurei

May interact with TAF1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016504

Structurei

3D structure databases

ProteinModelPortaliQ6DGG1
SMRiQ6DGG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD14 family.Curated

Phylogenomic databases

eggNOGiENOG410IHBA Eukaryota
COG0596 LUCA
GeneTreeiENSGT00510000046860
HOGENOMiHOG000028065
HOVERGENiHBG001936
InParanoidiQ6DGG1
KOiK13706
OMAiVMKGAGH
OrthoDBiEOG091G0VZR
PhylomeDBiQ6DGG1
TreeFamiTF314465

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR000073 AB_hydrolase_1
PfamiView protein in Pfam
PF12697 Abhydrolase_6, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DGG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVELSEGT IQVRGQSLFF REARPGNGQA VRFSVLLLHG IRFSSETWQN
60 70 80 90 100
LGTLHRLAEA GYRAVAIDLP GLGRSKEAAA PAPIGELAPG SFLAAVVDAL
110 120 130 140 150
ELGSLVVISP SLSGMYALPF LVAPESQLRG YVPVAPICTD KINAADYARV
160 170 180 190 200
KTPTLIVYGD QDPMGSSSFQ HLKQLPNHRV LVMEGAGHPC YLDKPDEWHT
210
GLLDFLQELA
Length:210
Mass (Da):22,618
Last modified:August 16, 2004 - v1
Checksum:i8BF0A2EE03D6CDEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076385 mRNA Translation: AAH76385.1
RefSeqiNP_001007665.1, NM_001007664.1
XP_006243786.1, XM_006243724.2
UniGeneiRn.2080

Genome annotation databases

EnsembliENSRNOT00000016504; ENSRNOP00000016504; ENSRNOG00000012073
GeneIDi300983
KEGGirno:300983
UCSCiRGD:1359649 rat

Similar proteinsi

Entry informationi

Entry nameiABHEB_RAT
AccessioniPrimary (citable) accession number: Q6DGG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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