Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein ABHD14B

Gene

Abhd14b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei111 – 1111Charge relay systemBy similarity
Active sitei162 – 1621Charge relay systemBy similarity
Active sitei188 – 1881Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-RNO-156584. Cytosolic sulfonation of small molecules.

Protein family/group databases

ESTHERirat-abheb. CIB-CCG1-interacting-factor-B.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ABHD14BCurated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 14BCurated
Short name:
Abhydrolase domain-containing protein 14BImported
Gene namesi
Name:Abhd14bImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1359649. Abhd14b.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly cytoplasmic.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Protein ABHD14BPRO_0000361280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei91 – 911PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6DGG1.
PRIDEiQ6DGG1.

PTM databases

iPTMnetiQ6DGG1.

Expressioni

Gene expression databases

ExpressionAtlasiQ6DGG1. baseline and differential.
GenevisibleiQ6DGG1. RN.

Interactioni

Subunit structurei

May interact with TAF1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016504.

Structurei

3D structure databases

ProteinModelPortaliQ6DGG1.
SMRiQ6DGG1. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. ABHD14 family.Curated

Phylogenomic databases

eggNOGiENOG410IHBA. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00510000046860.
HOGENOMiHOG000028065.
HOVERGENiHBG001936.
InParanoidiQ6DGG1.
KOiK13706.
OMAiFSSETWL.
OrthoDBiEOG7WDN4H.
PhylomeDBiQ6DGG1.
TreeFamiTF314465.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR026764. ABHD14B.
[Graphical view]
PANTHERiPTHR10992:SF281. PTHR10992:SF281. 1 hit.
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DGG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANVELSEGT IQVRGQSLFF REARPGNGQA VRFSVLLLHG IRFSSETWQN
60 70 80 90 100
LGTLHRLAEA GYRAVAIDLP GLGRSKEAAA PAPIGELAPG SFLAAVVDAL
110 120 130 140 150
ELGSLVVISP SLSGMYALPF LVAPESQLRG YVPVAPICTD KINAADYARV
160 170 180 190 200
KTPTLIVYGD QDPMGSSSFQ HLKQLPNHRV LVMEGAGHPC YLDKPDEWHT
210
GLLDFLQELA
Length:210
Mass (Da):22,618
Last modified:August 16, 2004 - v1
Checksum:i8BF0A2EE03D6CDEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076385 mRNA. Translation: AAH76385.1.
RefSeqiNP_001007665.1. NM_001007664.1.
XP_006243786.1. XM_006243724.1.
UniGeneiRn.2080.

Genome annotation databases

EnsembliENSRNOT00000016504; ENSRNOP00000016504; ENSRNOG00000012073.
GeneIDi300983.
KEGGirno:300983.
UCSCiRGD:1359649. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076385 mRNA. Translation: AAH76385.1.
RefSeqiNP_001007665.1. NM_001007664.1.
XP_006243786.1. XM_006243724.1.
UniGeneiRn.2080.

3D structure databases

ProteinModelPortaliQ6DGG1.
SMRiQ6DGG1. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016504.

Protein family/group databases

ESTHERirat-abheb. CIB-CCG1-interacting-factor-B.

PTM databases

iPTMnetiQ6DGG1.

Proteomic databases

PaxDbiQ6DGG1.
PRIDEiQ6DGG1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016504; ENSRNOP00000016504; ENSRNOG00000012073.
GeneIDi300983.
KEGGirno:300983.
UCSCiRGD:1359649. rat.

Organism-specific databases

CTDi84836.
RGDi1359649. Abhd14b.

Phylogenomic databases

eggNOGiENOG410IHBA. Eukaryota.
COG0596. LUCA.
GeneTreeiENSGT00510000046860.
HOGENOMiHOG000028065.
HOVERGENiHBG001936.
InParanoidiQ6DGG1.
KOiK13706.
OMAiFSSETWL.
OrthoDBiEOG7WDN4H.
PhylomeDBiQ6DGG1.
TreeFamiTF314465.

Enzyme and pathway databases

ReactomeiR-RNO-156584. Cytosolic sulfonation of small molecules.

Miscellaneous databases

PROiQ6DGG1.

Gene expression databases

ExpressionAtlasiQ6DGG1. baseline and differential.
GenevisibleiQ6DGG1. RN.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR000073. AB_hydrolase_1.
IPR026764. ABHD14B.
[Graphical view]
PANTHERiPTHR10992:SF281. PTHR10992:SF281. 1 hit.
PfamiPF12697. Abhydrolase_6. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiABHEB_RAT
AccessioniPrimary (citable) accession number: Q6DGG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: August 16, 2004
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.