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Protein

Probable palmitoyltransferase ZDHHC12

Gene

Zdhhc12

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei127S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC12 (EC:2.3.1.225)
Alternative name(s):
Zinc finger DHHC domain-containing protein 12
Short name:
DHHC-12
Gene namesi
Name:Zdhhc12
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1306593. Zdhhc12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128861 – 267Probable palmitoyltransferase ZDHHC12Add BLAST267

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ6DGF5.
PRIDEiQ6DGF5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015791.
GenevisibleiQ6DGF5. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039802.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini97 – 147DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00530000063074.
HOGENOMiHOG000232097.
HOVERGENiHBG058239.
InParanoidiQ6DGF5.
KOiK18932.
OMAiWPSGSWE.
OrthoDBiEOG091G0SSK.
PhylomeDBiQ6DGF5.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DGF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWPLLNSG MLVRTGHTVL TWGITLVLFL HDTELRQWEE QGELFLPLTF
60 70 80 90 100
LLLVLGSLLL YLAVSLMDPG YVTAQPQPQE EPKEEQTAMV PQAIPLRRCR
110 120 130 140 150
YCLVLQPLRA RHCRECRRCV RRYDHHCPWM ENCVGERNHP LFVAYLALQL
160 170 180 190 200
VVLLWGLYLA WSGLQFFQPW GLWLRSTGLL FTTFLLLSFF ALVVSLLLAS
210 220 230 240 250
HLYLVARNTT TWEFISSHRI AYLRQRTSNP FDRGPTRNLA HFFCGWPSGP
260
WETLWAEEEE EGSSQVV
Length:267
Mass (Da):31,029
Last modified:August 16, 2004 - v1
Checksum:i7D1435B5FC81A7F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY886528 mRNA. Translation: AAX73390.1.
BC076393 mRNA. Translation: AAH76393.1.
RefSeqiNP_001013257.1. NM_001013239.1.
UniGeneiRn.95138.

Genome annotation databases

EnsembliENSRNOT00000050908; ENSRNOP00000039802; ENSRNOG00000015791.
GeneIDi366014.
KEGGirno:366014.
UCSCiRGD:1306593. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZDH12_RAT
AccessioniPrimary (citable) accession number: Q6DGF5
Secondary accession number(s): Q2TGJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: August 16, 2004
Last modified: June 7, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families