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Protein

AN1-type zinc finger protein 6

Gene

Zfand6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri8 – 4235A20-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri161 – 20444AN1-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Protein transport, Transport

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 6
Alternative name(s):
Zinc finger A20 domain-containing protein 3
Gene namesi
Name:Zfand6
Synonyms:Za20d3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1359317. Zfand6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 223223AN1-type zinc finger protein 6PRO_0000245238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491PhosphoserineBy similarity
Modified residuei219 – 2191N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6DGF4.
PRIDEiQ6DGF4.

PTM databases

iPTMnetiQ6DGF4.
PhosphoSiteiQ6DGF4.

Expressioni

Gene expression databases

GenevisibleiQ6DGF4. RN.

Interactioni

Subunit structurei

Interacts with PKN1. Interacts with TRAF2. Interacts with mono- and polyubiquitin. Interacts with PEX6. Interacts with PEX5 (Cys-linked ubiquitinated) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018098.

Structurei

3D structure databases

ProteinModelPortaliQ6DGF4.
SMRiQ6DGF4. Positions 10-44, 150-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The A20-type zinc finger domain mediates regulation of NF-kappa-B activity.By similarity
The AN1-type zinc finger domain mediates association with TRAF2.By similarity

Sequence similaritiesi

Contains 1 A20-type zinc finger.PROSITE-ProRule annotation
Contains 1 AN1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri8 – 4235A20-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri161 – 20444AN1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3173. Eukaryota.
ENOG4111UWC. LUCA.
GeneTreeiENSGT00510000046525.
HOGENOMiHOG000238229.
HOVERGENiHBG053349.
InParanoidiQ6DGF4.
OMAiNVPEAQS.
OrthoDBiEOG7TTQ9W.
PhylomeDBiQ6DGF4.
TreeFamiTF313612.

Family and domain databases

Gene3Di4.10.1110.10. 1 hit.
InterProiIPR002653. Znf_A20.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01754. zf-A20. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view]
SMARTiSM00259. ZnF_A20. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view]
PROSITEiPS51036. ZF_A20. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DGF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQETNHSQA PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QNSSNGRISP
60 70 80 90 100
PAASVSSLSE SLPVQCADGS VPDAQSALDS TSSSMQPGPV SNQSLLSESV
110 120 130 140 150
APSQVDSTSV DKAVSETEDL QGPRAEGLVP LECDPPSSVS DTTQQPSEEQ
160 170 180 190 200
SKSLEKPKQK KNRCFMCRKK VGLTGFECRC GNVYCGVHRY SDVHNCSYNY
210 220
KADAAEKIRK ENPVVVGEKI QKI
Length:223
Mass (Da):24,001
Last modified:August 16, 2004 - v1
Checksum:iFFBF1A09EEC39901
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076394 mRNA. Translation: AAH76394.1.
RefSeqiNP_001007631.1. NM_001007630.1.
XP_006229561.1. XM_006229499.2.
XP_006229562.1. XM_006229500.2.
XP_006229564.1. XM_006229502.2.
XP_006229566.1. XM_006229504.1.
XP_008757833.1. XM_008759611.1.
UniGeneiRn.130357.

Genome annotation databases

EnsembliENSRNOT00000018098; ENSRNOP00000018098; ENSRNOG00000013506.
GeneIDi293067.
KEGGirno:293067.
UCSCiRGD:1359317. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076394 mRNA. Translation: AAH76394.1.
RefSeqiNP_001007631.1. NM_001007630.1.
XP_006229561.1. XM_006229499.2.
XP_006229562.1. XM_006229500.2.
XP_006229564.1. XM_006229502.2.
XP_006229566.1. XM_006229504.1.
XP_008757833.1. XM_008759611.1.
UniGeneiRn.130357.

3D structure databases

ProteinModelPortaliQ6DGF4.
SMRiQ6DGF4. Positions 10-44, 150-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018098.

PTM databases

iPTMnetiQ6DGF4.
PhosphoSiteiQ6DGF4.

Proteomic databases

PaxDbiQ6DGF4.
PRIDEiQ6DGF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018098; ENSRNOP00000018098; ENSRNOG00000013506.
GeneIDi293067.
KEGGirno:293067.
UCSCiRGD:1359317. rat.

Organism-specific databases

CTDi54469.
RGDi1359317. Zfand6.

Phylogenomic databases

eggNOGiKOG3173. Eukaryota.
ENOG4111UWC. LUCA.
GeneTreeiENSGT00510000046525.
HOGENOMiHOG000238229.
HOVERGENiHBG053349.
InParanoidiQ6DGF4.
OMAiNVPEAQS.
OrthoDBiEOG7TTQ9W.
PhylomeDBiQ6DGF4.
TreeFamiTF313612.

Miscellaneous databases

NextBioi635319.
PROiQ6DGF4.

Gene expression databases

GenevisibleiQ6DGF4. RN.

Family and domain databases

Gene3Di4.10.1110.10. 1 hit.
InterProiIPR002653. Znf_A20.
IPR000058. Znf_AN1.
[Graphical view]
PfamiPF01754. zf-A20. 1 hit.
PF01428. zf-AN1. 1 hit.
[Graphical view]
SMARTiSM00259. ZnF_A20. 1 hit.
SM00154. ZnF_AN1. 1 hit.
[Graphical view]
PROSITEiPS51036. ZF_A20. 1 hit.
PS51039. ZF_AN1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  2. "AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase."
    Miyata N., Okumoto K., Mukai S., Noguchi M., Fujiki Y.
    Traffic 13:168-183(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-40; 153-158; 181-201 AND 212-219, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiZFAN6_RAT
AccessioniPrimary (citable) accession number: Q6DGF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: August 16, 2004
Last modified: January 20, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.