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Q6DGD3 (SV91A_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase SUV39H1-A

EC=2.1.1.43
Alternative name(s):
Suppressor of variegation 3-9 homolog 1-A
Short name=Su(var)3-9 homolog 1-A
Gene names
Name:suv39h1a
Synonyms:suv39h1
ORF Names:si:dkey-16n15.2, zgc:101027
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as regulation of organ-specific terminal differentiation during development. Ref.4

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Subcellular location

Nucleus By similarity. Chromosomecentromere By similarity. Note: Associates with centromeric constitutive heterochromatin By similarity.

Tissue specificity

Expressed ubuitiously. Ref.3

Developmental stage

Expressed both maternally and zygotically. Ref.3

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

Contains 1 chromo domain.

Contains 1 post-SET domain.

Contains 1 pre-SET domain.

Contains 1 SET domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411Histone-lysine N-methyltransferase SUV39H1-A
PRO_0000281811

Regions

Domain43 – 10159Chromo
Domain178 – 23962Pre-SET
Domain242 – 365124SET
Domain395 – 41117Post-SET

Experimental info

Sequence conflict1391W → R in AAH76417. Ref.2
Sequence conflict1521M → L in AAH76417. Ref.2
Sequence conflict1831E → A in AAH76417. Ref.2
Sequence conflict2841Q → R in AAH76417. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q6DGD3 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 3C86D47CEC18C150

FASTA41147,471
        10         20         30         40         50         60 
MARDLKDCRV PCKLLLEDLQ ALCRRKKLVC KQLSVTKNNF NDYEVEYLCN YKKHKGREFF 

        70         80         90        100        110        120 
LVKWKGYEES ENTWEPLKNL KCPILLHQFR KDMKAALLQA NEPLDSASLS GPIISFLRQK 

       130        140        150        160        170        180 
ATQRIRLKKW EDLMNQTCWH KGRIFVSNEV DMDGPPKNFT YINENKLGKG VDMNAVIVGC 

       190        200        210        220        230        240 
ECEDCVSQPV DGCCPGLLKF RRAYNESRRV KVMPGVPIYE CNSKCRCGPD CANRVVQRGI 

       250        260        270        280        290        300 
QYDLCIFKTD NGRGWGVRTL QRINKNSFVM EYLGEIITTD EAEQRGVLYD KQGVTYLFDL 

       310        320        330        340        350        360 
DYVDDVYTID AAHYGNISHF VNHSCDPNLQ VYNVFIDNLD ERLPRIALFA KRGIKAGEEL 

       370        380        390        400        410 
TFDYKMTVDP VDAESTKMDL DFSRAGIEGS PIKRVHMECK CGVRNCRKYL F 

« Hide

References

« Hide 'large scale' references
[1]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[2]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[3]"Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes."
Sun X.-J., Xu P.-F., Zhou T., Hu M., Fu C.-T., Zhang Y., Jin Y., Chen Y., Chen S.-J., Huang Q.-H., Liu T.X., Chen Z.
PLoS ONE 3:E1499-E1499(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 214-409, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[4]"Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development."
Rai K., Nadauld L.D., Chidester S., Manos E.J., James S.R., Karpf A.R., Cairns B.R., Jones D.A.
Mol. Cell. Biol. 26:7077-7085(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX005340 Genomic DNA. Translation: CAQ14784.1.
BC076417 mRNA. Translation: AAH76417.1.
DQ840140 mRNA. Translation: ABI34869.1.
RefSeqNP_001003592.1. NM_001003592.1.
UniGeneDr.80633.

3D structure databases

ProteinModelPortalQ6DGD3.
SMRQ6DGD3. Positions 115-410.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000038955; ENSDARP00000034818; ENSDARG00000026799.
GeneID445198.
KEGGdre:445198.

Organism-specific databases

CTD445198.
ZFINZDB-GENE-040801-111. suv39h1a.

Phylogenomic databases

eggNOGCOG2940.
GeneTreeENSGT00750000117355.
HOGENOMHOG000231244.
HOVERGENHBG055621.
InParanoidQ6DGD3.
KOK11419.
OMAWEDEINE.
OrthoDBEOG7RJPR0.
PhylomeDBQ6DGD3.
TreeFamTF106452.

Gene expression databases

BgeeQ6DGD3.

Family and domain databases

InterProIPR023780. Chromo_domain.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFPIRSF009343. SUV39_SET. 1 hit.
SMARTSM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMSSF54160. SSF54160. 1 hit.
PROSITEPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20831958.

Entry information

Entry nameSV91A_DANRE
AccessionPrimary (citable) accession number: Q6DGD3
Secondary accession number(s): A5XBP4, B0S580
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 14, 2008
Last modified: April 16, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families