Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

GTPase NRas

Gene

nras

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-1169092. Activation of RAS in B cells.
R-DRE-1250347. SHC1 events in ERBB4 signaling.
R-DRE-1433557. Signaling by SCF-KIT.
R-DRE-171007. p38MAPK events.
R-DRE-179812. GRB2 events in EGFR signaling.
R-DRE-180336. SHC1 events in EGFR signaling.
R-DRE-186763. Downstream signal transduction.
R-DRE-1963640. GRB2 events in ERBB2 signaling.
R-DRE-210993. Tie2 Signaling.
R-DRE-2179392. EGFR Transactivation by Gastrin.
R-DRE-2424491. DAP12 signaling.
R-DRE-2871796. FCERI mediated MAPK activation.
R-DRE-375165. NCAM signaling for neurite out-growth.
R-DRE-5218921. VEGFR2 mediated cell proliferation.
R-DRE-5621575. CD209 (DC-SIGN) signaling.
R-DRE-5654688. SHC-mediated cascade:FGFR1.
R-DRE-5654693. FRS-mediated FGFR1 signaling.
R-DRE-5654699. SHC-mediated cascade:FGFR2.
R-DRE-5654700. FRS-mediated FGFR2 signaling.
R-DRE-5654704. SHC-mediated cascade:FGFR3.
R-DRE-5654706. FRS-mediated FGFR3 signaling.
R-DRE-5654712. FRS-mediated FGFR4 signaling.
R-DRE-5654719. SHC-mediated cascade:FGFR4.
R-DRE-5658442. Regulation of RAS by GAPs.
R-DRE-5673000. RAF activation.
R-DRE-5673001. RAF/MAP kinase cascade.
R-DRE-5674135. MAP2K and MAPK activation.
R-DRE-5675221. Negative regulation of MAPK pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
GTPase NRasImported
Submitted name:
Neuroblastoma RAS viral (V-ras) oncogene homologImported
Gene namesi
Name:nrasImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-990415-166. nras.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000055741.

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOVERGENiHBG009351.
OMAiFAVNNAK.
OrthoDBiEOG7QVM41.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DGD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET
60 70 80 90 100
CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADVHLYREQI
110 120 130 140 150
KRVKDSDDVP MVLVGNKCDL ARTVDTKQAQ ELARSYGIEF VETSAKTRQG
160 170 180
VEDAFYTLVR EIRHYRMKKL NSREDRKQGC LGVSCEVM
Length:188
Mass (Da):21,354
Last modified:August 16, 2004 - v1
Checksum:iB177DB9B455BCFDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT027601 Genomic DNA. No translation available.
CU928015 Genomic DNA. No translation available.
BC076419 mRNA. Translation: AAH76419.1.
UniGeneiDr.233.

Genome annotation databases

EnsembliENSDART00000055742; ENSDARP00000055741; ENSDARG00000038225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT027601 Genomic DNA. No translation available.
CU928015 Genomic DNA. No translation available.
BC076419 mRNA. Translation: AAH76419.1.
UniGeneiDr.233.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000055741.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000055742; ENSDARP00000055741; ENSDARG00000038225.

Organism-specific databases

ZFINiZDB-GENE-990415-166. nras.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121849.
HOVERGENiHBG009351.
OMAiFAVNNAK.
OrthoDBiEOG7QVM41.
TreeFamiTF312796.

Enzyme and pathway databases

ReactomeiR-DRE-1169092. Activation of RAS in B cells.
R-DRE-1250347. SHC1 events in ERBB4 signaling.
R-DRE-1433557. Signaling by SCF-KIT.
R-DRE-171007. p38MAPK events.
R-DRE-179812. GRB2 events in EGFR signaling.
R-DRE-180336. SHC1 events in EGFR signaling.
R-DRE-186763. Downstream signal transduction.
R-DRE-1963640. GRB2 events in ERBB2 signaling.
R-DRE-210993. Tie2 Signaling.
R-DRE-2179392. EGFR Transactivation by Gastrin.
R-DRE-2424491. DAP12 signaling.
R-DRE-2871796. FCERI mediated MAPK activation.
R-DRE-375165. NCAM signaling for neurite out-growth.
R-DRE-5218921. VEGFR2 mediated cell proliferation.
R-DRE-5621575. CD209 (DC-SIGN) signaling.
R-DRE-5654688. SHC-mediated cascade:FGFR1.
R-DRE-5654693. FRS-mediated FGFR1 signaling.
R-DRE-5654699. SHC-mediated cascade:FGFR2.
R-DRE-5654700. FRS-mediated FGFR2 signaling.
R-DRE-5654704. SHC-mediated cascade:FGFR3.
R-DRE-5654706. FRS-mediated FGFR3 signaling.
R-DRE-5654712. FRS-mediated FGFR4 signaling.
R-DRE-5654719. SHC-mediated cascade:FGFR4.
R-DRE-5658442. Regulation of RAS by GAPs.
R-DRE-5673000. RAF activation.
R-DRE-5673001. RAF/MAP kinase cascade.
R-DRE-5674135. MAP2K and MAPK activation.
R-DRE-5675221. Negative regulation of MAPK pathway.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Singapore local strainImported.
    Tissue: EmbryoImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ6DGD1_DANRE
AccessioniPrimary (citable) accession number: Q6DGD1
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.