Reviewed, UniProtKB/Swiss-Prot Q6DGA6 (ALLC_DANRE)

Names and origin

Protein names

Recommended name:
    Allantoicase
    EC=3.5.3.4
Alternative name(s):
    Allantoate amidinohydrolase

Gene names

Name:	allc
ORF Names:	si:ch211-284k10.3, zgc:91799

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	395 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Utilization of purines as secondary nitrogen sources, when primary sources are limiting By similarity.
Catalytic activity	Allantoate + H2O = (S)-ureidoglycolate + urea.
Pathway	Nitrogen metabolism; (S)-allantoin degradation; (S)-ureidoglycolate from allantoate (aminidohydrolase route): step 1/1.
Sequence similarities	Belongs to the allantoicase family.
Sequence caution	The sequence CAH68966.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAH68967.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Purine metabolism
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	purine base metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	allantoicase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6DGA6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q6DGA6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     78-103: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 395	395	Allantoicase		PRO_0000205909
Natural variations
	Alternative sequence	78 – 103	26	Missing in isoform 2.		VSP_029174

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: E7D4B5DBB6D9A0E7	FASTA	395	44,144
	10 20 30 40 50 60 MAKRQVQKET RSQPHFLQFN NLACETAGGK VIFATDEWFA PARNLLKRDP PEFIASAFTE 70 80 90 100 110 120 FGKWMDGWET RRKRIPGHDW CIVQLGVPGI IHGFDVDTSF FTGNYAPFAS IQATCLDQMP 130 140 150 160 170 180 SIALEGDRTG MAASPSQFEA VAQLNSDSWK EVVPVTKLKA GYSDTCHNYL SVSYPHRVTH 190 200 210 220 230 240 IRFNIYPDGG IARLKVYGIG KKDWSSVFGQ DLVDLVALVN GGVCVGFSDA HYGHPRNMIG 250 260 270 280 290 300 LGMAENMGDG WETARRLDRP RVLKEDENGI LQVPGSEWAI FRLGHPGIIS KIELDTNHFK 310 320 330 340 350 360 GNFPDSCRIE ACSLTEDEEN SFIQSQWSSD RSPMWNILLP PQKMKAHHRH VFSGPSLVHC 370 380 390 GPVSHVRMVI APDGGISRLR IWGRPVSSHQ MISKL
	Isoform 2. Checksum: 0727DBF963275956	FASTA	369	41,301
	10 20 30 40 50 60 MAKRQVQKET RSQPHFLQFN NLACETAGGK VIFATDEWFA PARNLLKRDP PEFIASAFTE 70 80 90 100 110 120 FGKWMDGWET RRKRIPGNYA PFASIQATCL DQMPSIALEG DRTGMAASPS QFEAVAQLNS 130 140 150 160 170 180 DSWKEVVPVT KLKAGYSDTC HNYLSVSYPH RVTHIRFNIY PDGGIARLKV YGIGKKDWSS 190 200 210 220 230 240 VFGQDLVDLV ALVNGGVCVG FSDAHYGHPR NMIGLGMAEN MGDGWETARR LDRPRVLKED 250 260 270 280 290 300 ENGILQVPGS EWAIFRLGHP GIISKIELDT NHFKGNFPDS CRIEACSLTE DEENSFIQSQ 310 320 330 340 350 360 WSSDRSPMWN ILLPPQKMKA HHRHVFSGPS LVHCGPVSHV RMVIAPDGGI SRLRIWGRPV SSHQMISKL

References

[1]	The Danio rerio sequencing project at the Sanger Institute Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen.
[2]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX276180 Genomic DNA. Translation: CAH68966.1. Sequence problems. BX276180 Genomic DNA. Translation: CAH68967.1. Sequence problems. BC076445 mRNA. Translation: AAH76445.1.
IPI	IPI00495171. IPI00631948.
RefSeq	NP_001002716.1.
UniGene	Dr.89100
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6DGA6.
Genome annotation databases
Ensembl	ENSDART00000062429; ENSDARP00000062428; ENSDARG00000042562; Danio rerio. [Genome view]
GeneID	436989.
KEGG	dre:436989.
Organism-specific databases
CTD	436989.
ZFIN	ZDB-GENE-040718-471. allc.
Phylogenomic databases
HOGENOM	Q6DGA6.
HOVERGEN	Q6DGA6.
Enzyme and pathway databases
BRENDA	3.5.3.4. 96826.
Gene expression databases
Bgee	Q6DGA6.
Family and domain databases
InterPro	IPR005164. Allantoicase. IPR015908. Allantoicase_region. [Graphical view]
PANTHER	PTHR12045. Allantoicase. 1 hit.
Pfam	PF03561. Allantoicase. 2 hits. [Graphical view]
TIGRFAMs	TIGR02961. allantoicase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ALLC_DANRE

Accession

Primary (citable) accession number: Q6DGA6
Secondary accession number(s): Q5TZA9, Q5TZB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2005
Last sequence update:	August 16, 2004
Last modified:	September 1, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project