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Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

ube2z

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in apoptosis regulation (By similarity).PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ligase activity Source: UniProtKB-KW

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. protein ubiquitination Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Apoptosis, Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Z (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z
Gene namesi
Name:ube2z
ORF Names:zgc:92419
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040718-15. ube2z.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Ubiquitin-conjugating enzyme E2 ZPRO_0000280518Add
BLAST

Expressioni

Gene expression databases

BgeeiQ6DG60.

Structurei

3D structure databases

ProteinModelPortaliQ6DG60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5078.
HOVERGENiHBG083204.
InParanoidiQ6DG60.
KOiK10585.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DG60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHTITPAVE SGLGVLTHAV SSTVPVAVLP SLPPGIGSGV PAGAGLLSQI
60 70 80 90 100
HATSWDPTLS TDWDNEKASQ QCILRIKRDI MSIYKEPPPG MFVVPDPHDM
110 120 130 140 150
TKIHALITGP FDTPYEGGFF LFLFRCPPDY PIHPPRVKLI TTGHNTVRFN
160 170 180 190 200
PNFYRNGKVC LSILGTWTGP AWSPAQSISS VLISIQSLMT ENPYHNEPGF
210 220 230 240 250
EQERHPGDSK NYNECIRHET MRVAVCDMLE GKVSCPEALW SVMEKSFLEY
260 270 280 290 300
YDFYEGVCKE RLHLQGQNMQ DPFGEKRGRF DYQGLLTRLR AIQRRLREKC
310 320
PPEDNDGDSD SDTSSSGTDP DSQGSSQP
Length:328
Mass (Da):36,451
Last modified:March 20, 2007 - v2
Checksum:i96233C7E09C4D612
GO

Sequence cautioni

The sequence AAH76491.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076491 mRNA. Translation: AAH76491.1. Different initiation.
RefSeqiNP_001002330.2. NM_001002330.4.
UniGeneiDr.83806.

Genome annotation databases

GeneIDi436602.
KEGGidre:436602.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076491 mRNA. Translation: AAH76491.1. Different initiation.
RefSeqiNP_001002330.2. NM_001002330.4.
UniGeneiDr.83806.

3D structure databases

ProteinModelPortaliQ6DG60.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi436602.
KEGGidre:436602.

Organism-specific databases

CTDi65264.
ZFINiZDB-GENE-040718-15. ube2z.

Phylogenomic databases

eggNOGiCOG5078.
HOVERGENiHBG083204.
InParanoidiQ6DG60.
KOiK10585.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

NextBioi20831050.
PROiQ6DG60.

Gene expression databases

BgeeiQ6DG60.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiUBE2Z_DANRE
AccessioniPrimary (citable) accession number: Q6DG60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: March 4, 2015
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.