Q6DG60 (UBE2Z_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-conjugating enzyme E2 Z
EC=6.3.2.19

Alternative name(s):
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z

Gene names

Name:	ube2z
ORF Names:	zgc:92419

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in apoptosis regulation By similarity.
Catalytic activity	ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
Pathway	Protein modification; protein ubiquitination.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the ubiquitin-conjugating enzyme family.
Sequence caution	The sequence AAH76491.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Apoptosis Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin-protein ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Ubiquitin-conjugating enzyme E2 Z		PRO_0000280518
Sites
	Active site	160	1	Glycyl thioester intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6DG60 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: 96233C7E09C4D612	FASTA	328	36,451
	10 20 30 40 50 60 MAHTITPAVE SGLGVLTHAV SSTVPVAVLP SLPPGIGSGV PAGAGLLSQI HATSWDPTLS 70 80 90 100 110 120 TDWDNEKASQ QCILRIKRDI MSIYKEPPPG MFVVPDPHDM TKIHALITGP FDTPYEGGFF 130 140 150 160 170 180 LFLFRCPPDY PIHPPRVKLI TTGHNTVRFN PNFYRNGKVC LSILGTWTGP AWSPAQSISS 190 200 210 220 230 240 VLISIQSLMT ENPYHNEPGF EQERHPGDSK NYNECIRHET MRVAVCDMLE GKVSCPEALW 250 260 270 280 290 300 SVMEKSFLEY YDFYEGVCKE RLHLQGQNMQ DPFGEKRGRF DYQGLLTRLR AIQRRLREKC 310 320 PPEDNDGDSD SDTSSSGTDP DSQGSSQP

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC076491 mRNA. Translation: AAH76491.1. Different initiation.
IPI	IPI00866604.
RefSeq	NP_001002330.2. NM_001002330.3.
UniGene	Dr.83806.
3D structure databases
ProteinModelPortal	Q6DG60.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	436602.
KEGG	dre:436602.
Organism-specific databases
CTD	65264.
ZFIN	ZDB-GENE-040718-15. ube2z.
Phylogenomic databases
eggNOG	COG5078.
HOVERGEN	HBG083204.
InParanoid	Q6DG60.
KO	K10585.
OrthoDB	EOG4ZCT54.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
Bgee	Q6DG60.
Family and domain databases
Gene3D	3.10.110.10. 1 hit.
InterPro	IPR000608. UBQ-conjugat_E2. IPR016135. UBQ-conjugating_enzyme/RWD. [Graphical view]
Pfam	PF00179. UQ_con. 1 hit. [Graphical view]
SUPFAM	SSF54495. UBQ-conjugat/RWD-like. 1 hit.
PROSITE	PS00183. UBIQUITIN_CONJUGAT_1. False negative. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20831050.

Entry information

Entry name

UBE2Z_DANRE

Accession

Primary (citable) accession number: Q6DG60

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	May 29, 2013
This is version 72 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program