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Q6DG60 (UBE2Z_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 Z

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein Z
Ubiquitin-protein ligase Z
Gene names
Name:ube2z
ORF Names:zgc:92419
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in apoptosis regulation By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence caution

The sequence AAH76491.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processApoptosis
Ubl conjugation pathway
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ubiquitin-protein transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Ubiquitin-conjugating enzyme E2 Z
PRO_0000280518

Sites

Active site1601Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6DG60 [UniParc].

Last modified March 20, 2007. Version 2.
Checksum: 96233C7E09C4D612

FASTA32836,451
        10         20         30         40         50         60 
MAHTITPAVE SGLGVLTHAV SSTVPVAVLP SLPPGIGSGV PAGAGLLSQI HATSWDPTLS 

        70         80         90        100        110        120 
TDWDNEKASQ QCILRIKRDI MSIYKEPPPG MFVVPDPHDM TKIHALITGP FDTPYEGGFF 

       130        140        150        160        170        180 
LFLFRCPPDY PIHPPRVKLI TTGHNTVRFN PNFYRNGKVC LSILGTWTGP AWSPAQSISS 

       190        200        210        220        230        240 
VLISIQSLMT ENPYHNEPGF EQERHPGDSK NYNECIRHET MRVAVCDMLE GKVSCPEALW 

       250        260        270        280        290        300 
SVMEKSFLEY YDFYEGVCKE RLHLQGQNMQ DPFGEKRGRF DYQGLLTRLR AIQRRLREKC 

       310        320 
PPEDNDGDSD SDTSSSGTDP DSQGSSQP 

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC076491 mRNA. Translation: AAH76491.1. Different initiation.
RefSeqNP_001002330.2. NM_001002330.3.
UniGeneDr.83806.

3D structure databases

ProteinModelPortalQ6DG60.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID436602.
KEGGdre:436602.

Organism-specific databases

CTD65264.
ZFINZDB-GENE-040718-15. ube2z.

Phylogenomic databases

eggNOGCOG5078.
HOVERGENHBG083204.
InParanoidQ6DG60.
KOK10585.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

BgeeQ6DG60.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20831050.
PROQ6DG60.

Entry information

Entry nameUBE2Z_DANRE
AccessionPrimary (citable) accession number: Q6DG60
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: February 19, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways