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Q6DG60

- UBE2Z_DANRE

UniProt

Q6DG60 - UBE2Z_DANRE

Protein

Ubiquitin-conjugating enzyme E2 Z

Gene

ube2z

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in apoptosis regulation By similarity.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei160 – 1601Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. protein ubiquitination Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Apoptosis, Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Z (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein Z
    Ubiquitin-protein ligase Z
    Gene namesi
    Name:ube2z
    ORF Names:zgc:92419
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040718-15. ube2z.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Ubiquitin-conjugating enzyme E2 ZPRO_0000280518Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiQ6DG60.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DG60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5078.
    HOVERGENiHBG083204.
    InParanoidiQ6DG60.
    KOiK10585.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DG60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHTITPAVE SGLGVLTHAV SSTVPVAVLP SLPPGIGSGV PAGAGLLSQI    50
    HATSWDPTLS TDWDNEKASQ QCILRIKRDI MSIYKEPPPG MFVVPDPHDM 100
    TKIHALITGP FDTPYEGGFF LFLFRCPPDY PIHPPRVKLI TTGHNTVRFN 150
    PNFYRNGKVC LSILGTWTGP AWSPAQSISS VLISIQSLMT ENPYHNEPGF 200
    EQERHPGDSK NYNECIRHET MRVAVCDMLE GKVSCPEALW SVMEKSFLEY 250
    YDFYEGVCKE RLHLQGQNMQ DPFGEKRGRF DYQGLLTRLR AIQRRLREKC 300
    PPEDNDGDSD SDTSSSGTDP DSQGSSQP 328
    Length:328
    Mass (Da):36,451
    Last modified:March 20, 2007 - v2
    Checksum:i96233C7E09C4D612
    GO

    Sequence cautioni

    The sequence AAH76491.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC076491 mRNA. Translation: AAH76491.1. Different initiation.
    RefSeqiNP_001002330.2. NM_001002330.3.
    UniGeneiDr.83806.

    Genome annotation databases

    GeneIDi436602.
    KEGGidre:436602.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC076491 mRNA. Translation: AAH76491.1 . Different initiation.
    RefSeqi NP_001002330.2. NM_001002330.3.
    UniGenei Dr.83806.

    3D structure databases

    ProteinModelPortali Q6DG60.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 436602.
    KEGGi dre:436602.

    Organism-specific databases

    CTDi 65264.
    ZFINi ZDB-GENE-040718-15. ube2z.

    Phylogenomic databases

    eggNOGi COG5078.
    HOVERGENi HBG083204.
    InParanoidi Q6DG60.
    KOi K10585.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 20831050.
    PROi Q6DG60.

    Gene expression databases

    Bgeei Q6DG60.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiUBE2Z_DANRE
    AccessioniPrimary (citable) accession number: Q6DG60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3