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Protein

TANK-binding kinase 1-binding protein 1

Gene

Tbkbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
TANK-binding kinase 1-binding protein 1
Short name:
TBK1-binding protein 1
Alternative name(s):
Protein ProSAPiP2
Gene namesi
Name:Tbkbp1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi631328. Tbkbp1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246561 – 613TANK-binding kinase 1-binding protein 1Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineBy similarity1
Modified residuei365PhosphoserineBy similarity1
Modified residuei372PhosphoserineBy similarity1
Modified residuei379PhosphoserineBy similarity1
Modified residuei385PhosphoserineBy similarity1
Modified residuei400PhosphoserineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei502PhosphoserineBy similarity1
Modified residuei532PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6DG50.
PRIDEiQ6DG50.

PTM databases

iPTMnetiQ6DG50.
PhosphoSitePlusiQ6DG50.

Expressioni

Gene expression databases

BgeeiENSRNOG00000009370.
GenevisibleiQ6DG50. RN.

Interactioni

Subunit structurei

Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012461.

Structurei

3D structure databases

ProteinModelPortaliQ6DG50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 280HomodimerizationBy similarityAdd BLAST280
Regioni281 – 330Interaction with TBK1 and IKBKEBy similarityAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili48 – 162Sequence analysisAdd BLAST115
Coiled coili218 – 277Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi168 – 173Poly-GlnSequence analysis6
Compositional biasi344 – 432Pro-richSequence analysisAdd BLAST89
Compositional biasi520 – 523Poly-GluSequence analysis4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJJ. Eukaryota.
ENOG410ZK7E. LUCA.
GeneTreeiENSGT00390000008865.
HOGENOMiHOG000154514.
HOVERGENiHBG108550.
InParanoidiQ6DG50.
KOiK12652.
OMAiYGGELYG.
OrthoDBiEOG091G06LV.
PhylomeDBiQ6DG50.
TreeFamiTF331289.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DG50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESMFEDDIS ILTQEALGPS EVWLDGPGDP SLGGDMCSAS HFALITAYGD
60 70 80 90 100
IKERLGGLER ENATLRRRLK VYEIKYPLIT DFGEEHGFPL YEIKDGSLLE
110 120 130 140 150
VEKVSLQQRL NQFQHELQKN KEQEEQLGEM IQAYEKLCVE KSDLETELGE
160 170 180 190 200
MRALVETHLR QICGLEKQLQ QQQGLRDAAF SSLSPPAVPA TACPDLDLHY
210 220 230 240 250
LALRGGPALG HAGWPGPTSV SVSELERRRL EEALEAAQGE ARGAQLREEQ
260 270 280 290 300
LQAECERLQG ELKQLQETRA QDLASNQSEC GMAWVKRVGD DQVNLALAYT
310 320 330 340 350
ELTEELGRLR ELSSLQGRIL RTLLQEQARN AGQRHSPLSQ RHSPAPACPS
360 370 380 390 400
PSPPARPPPC APCQSPAAQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS
410 420 430 440 450
PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPGERTLAER AYAKPPSHHA
460 470 480 490 500
KAGFQGRRSY SELAEGAAYA AASPAWLQAE AATLPKPRAY GGELYGPGRP
510 520 530 540 550
LSPRRAFEGI RLRFEKQPSE EEEWAMPASP PSPEASTIRC ASFCAGFPIP
560 570 580 590 600
ESPAATAYAH AEHAQSWPSI NLLMETVGSD IRSCPLCQLG FPVGYPDDAL
610
IKHIDSHLEN SKI
Length:613
Mass (Da):67,155
Last modified:August 16, 2004 - v1
Checksum:i7990F0E5949D1DBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26G → S in CAC82181 (Ref. 1) Curated1
Sequence conflicti222 – 223Missing in CAC82181 (Ref. 1) Curated2
Sequence conflicti401P → R in CAC82181 (Ref. 1) Curated1
Sequence conflicti408S → F in CAC82181 (Ref. 1) Curated1
Sequence conflicti416P → L in CAC82181 (Ref. 1) Curated1
Sequence conflicti427R → G in CAC82181 (Ref. 1) Curated1
Sequence conflicti431P → PHP in CAC82181 (Ref. 1) Curated1
Sequence conflicti443A → V in CAC82181 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278800 mRNA. Translation: CAC82181.1.
BC076503 mRNA. Translation: AAH76503.1.
RefSeqiNP_742018.2. NM_172021.2.
UniGeneiRn.33571.

Genome annotation databases

EnsembliENSRNOT00000012462; ENSRNOP00000012461; ENSRNOG00000009370.
GeneIDi266764.
KEGGirno:266764.
UCSCiRGD:631328. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278800 mRNA. Translation: CAC82181.1.
BC076503 mRNA. Translation: AAH76503.1.
RefSeqiNP_742018.2. NM_172021.2.
UniGeneiRn.33571.

3D structure databases

ProteinModelPortaliQ6DG50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012461.

PTM databases

iPTMnetiQ6DG50.
PhosphoSitePlusiQ6DG50.

Proteomic databases

PaxDbiQ6DG50.
PRIDEiQ6DG50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012462; ENSRNOP00000012461; ENSRNOG00000009370.
GeneIDi266764.
KEGGirno:266764.
UCSCiRGD:631328. rat.

Organism-specific databases

CTDi9755.
RGDi631328. Tbkbp1.

Phylogenomic databases

eggNOGiENOG410IGJJ. Eukaryota.
ENOG410ZK7E. LUCA.
GeneTreeiENSGT00390000008865.
HOGENOMiHOG000154514.
HOVERGENiHBG108550.
InParanoidiQ6DG50.
KOiK12652.
OMAiYGGELYG.
OrthoDBiEOG091G06LV.
PhylomeDBiQ6DG50.
TreeFamiTF331289.

Miscellaneous databases

PROiQ6DG50.

Gene expression databases

BgeeiENSRNOG00000009370.
GenevisibleiQ6DG50. RN.

Family and domain databases

InterProiIPR024581. TBD.
[Graphical view]
PfamiPF12845. TBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBKB1_RAT
AccessioniPrimary (citable) accession number: Q6DG50
Secondary accession number(s): Q8K1Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.