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Q6DG22 (ADA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:ada
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation By similarity.

Catalytic activity

Adenosine + H2O = inosine + NH3.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein; Extracellular side By similarity. Cell junction By similarity. Cytoplasmic vesicle lumen By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the adenosine and AMP deaminases family.

Sequence caution

The sequence AAH76532.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Adenosine deaminase
PRO_0000194356

Sites

Active site2161Proton donor By similarity
Metal binding151Zinc; catalytic By similarity
Metal binding171Zinc; catalytic By similarity
Metal binding2131Zinc; catalytic By similarity
Metal binding2951Zinc; catalytic By similarity
Binding site171Substrate By similarity
Binding site191Substrate By similarity
Binding site1841Substrate; via amide nitrogen and carbonyl oxygen By similarity
Binding site2961Substrate By similarity
Site2371Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6DG22 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: B389F4EC527586A7

FASTA35940,844
        10         20         30         40         50         60 
MNGKPAFDKP KVELHVHLDG AIRLKTVLDV AKRRGISLPV SMEEELKELC TVNEPATLTE 

        70         80         90        100        110        120 
FLGKFSHFMH VIAGDREAIK RIAYEFVETK AKEGVIYVEA RYSPHFLANK GVEPLPWDQK 

       130        140        150        160        170        180 
PGDITPDDVV DLVNQGFKEG EQAFKTKARS ILCCMRHMPN WSMEVVELCK KFHKDGVVAI 

       190        200        210        220        230        240 
DLAGDESMNC ESYPGHKKAF EEAVRSNVHR TVHAGEVGPA SVVREAVEVL KAERIGHGYH 

       250        260        270        280        290        300 
TLEDQNLYKQ LLHQNMHFEM CPVSSRLTGA CEPDFTKHPL ITFKKDKANY SLNTDDPTIF 

       310        320        330        340        350 
NSTLNSDYEV VQKYMDFTEE EFKRLNINAA KSCFLPEKEK EKLLNQLYEA YGMRKSTSF

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC076532 mRNA. Translation: AAH76532.1. Different initiation.
IPIIPI00502388.
RefSeqNP_001002646.1. NM_001002646.1.
UniGeneDr.88169.

3D structure databases

ProteinModelPortalQ6DG22.
SMRQ6DG22. Positions 5-351.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6DG22.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID436919.
KEGGdre:436919.

Organism-specific databases

CTD100.
ZFINZDB-GENE-040718-393. ada.

Phylogenomic databases

eggNOGfiNOG04747.
GeneTreeENSGT00510000047600.
HOGENOMHBG630382.
HOVERGENHBG001718.
InParanoidQ6DG22.
OrthoDBEOG40K808.
PhylomeDBQ6DG22.

Gene expression databases

BgeeQ6DG22.

Family and domain databases

InterProIPR006650. A/AMP_deam_AS.
IPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADA_DANRE
AccessionPrimary (citable) accession number: Q6DG22
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: December 14, 2011
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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