Reviewed, UniProtKB/Swiss-Prot Q6DG22 (ADA_DANRE)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:

ada

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May act as a positive regulator of T-cell coactivation By similarity.
Catalytic activity	Adenosine + H2O = inosine + NH3.
Subcellular location	Cell membrane By similarity. Cell junction By similarity.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cell junction Cell membrane Membrane
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 359	359	Adenosine deaminase		PRO_0000194356
Sites
	Active site	213	1	Potential
	Active site	261	1	Potential
	Active site	295	1	Potential
	Active site	296	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6DG22-1 [UniParc]. Last modified November 8, 2005. Version 2. Checksum: B389F4EC527586A7	FASTA	359	40,844
	10 20 30 40 50 60 MNGKPAFDKP KVELHVHLDG AIRLKTVLDV AKRRGISLPV SMEEELKELC TVNEPATLTE 70 80 90 100 110 120 FLGKFSHFMH VIAGDREAIK RIAYEFVETK AKEGVIYVEA RYSPHFLANK GVEPLPWDQK 130 140 150 160 170 180 PGDITPDDVV DLVNQGFKEG EQAFKTKARS ILCCMRHMPN WSMEVVELCK KFHKDGVVAI 190 200 210 220 230 240 DLAGDESMNC ESYPGHKKAF EEAVRSNVHR TVHAGEVGPA SVVREAVEVL KAERIGHGYH 250 260 270 280 290 300 TLEDQNLYKQ LLHQNMHFEM CPVSSRLTGA CEPDFTKHPL ITFKKDKANY SLNTDDPTIF 310 320 330 340 350 NSTLNSDYEV VQKYMDFTEE EFKRLNINAA KSCFLPEKEK EKLLNQLYEA YGMRKSTSF

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC076532 mRNA. Translation: AAH76532.1. Different initiation.
IPI	IPI00502388.
RefSeq	NP_001002646.1.
UniGene	Dr.88169
3D structure databases
SMR	Q6DG22. Positions 5-351.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6DG22.
Genome annotation databases
Ensembl	ENSDART00000019519; ENSDARP00000005284; ENSDARG00000003113; Danio rerio. [Genome view]
GeneID	436919.
KEGG	dre:436919.
Organism-specific databases
CTD	436919.
ZFIN	ZDB-GENE-040718-393. ada.
Phylogenomic databases
eggNOG	fiNOG04747.
HOGENOM	HBG630382.
HOVERGEN	Q6DG22.
InParanoid	Q6DG22.
PhylomeDB	Q6DG22.
Enzyme and pathway databases
BRENDA	3.5.4.4. 96826.
Gene expression databases
Bgee	Q6DG22.
Family and domain databases
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADA_DANRE

Accession

Primary (citable) accession number: Q6DG22

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	February 9, 2010
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project