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Protein

Molybdate-anion transporter

Gene

mfsd5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi2.A.1.40.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdate-anion transporter
Alternative name(s):
Major facilitator superfamily domain-containing protein 5
Molybdate transporter 2 homolog
Gene namesi
Name:mfsd5
ORF Names:zgc:91807
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-040718-468. mfsd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence analysisAdd
BLAST
Transmembranei47 – 6721HelicalSequence analysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence analysisAdd
BLAST
Transmembranei201 – 22121HelicalSequence analysisAdd
BLAST
Transmembranei276 – 29621HelicalSequence analysisAdd
BLAST
Transmembranei306 – 32621HelicalSequence analysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence analysisAdd
BLAST
Transmembranei371 – 39121HelicalSequence analysisAdd
BLAST
Transmembranei403 – 42321HelicalSequence analysisAdd
BLAST
Transmembranei443 – 46321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 481481Molybdate-anion transporterPRO_0000273404Add
BLAST

Proteomic databases

PaxDbiQ6DG19.

Expressioni

Gene expression databases

BgeeiQ6DG19.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004281.

Structurei

3D structure databases

ProteinModelPortaliQ6DG19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4332. Eukaryota.
ENOG410XSP5. LUCA.
GeneTreeiENSGT00390000012629.
HOGENOMiHOG000239662.
HOVERGENiHBG081970.
InParanoidiQ6DG19.
OMAiFESVLYI.
OrthoDBiEOG71ZP22.
PhylomeDBiQ6DG19.
TreeFamiTF328562.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR008509. MOT2/MFSD5.
[Graphical view]
PfamiPF05631. MFS_5. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DG19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVTAYLAFI VLAGLCVALE ITARRLTLSQ ATQTAVANPA FQRFQKLFLK
60 70 80 90 100
AYLLALWADW LQGPYLYKLY RHYNFLESQI AILYVCGLAS CVLFAPVAGW
110 120 130 140 150
LPQFLGRRQT CLLFCLAYSV CCITKLSQDY FMLILGRVLG GLSTSLLTTT
160 170 180 190 200
FEAWYVHGHV DIHDFPKEWI PVTFGKVANW NYGLAVGAGL VANLFAEWLG
210 220 230 240 250
LGPVAPFLLA IPSLAACAWF VLSEWGQEDK QEGMNGDKNA PLLNSLNTPK
260 270 280 290 300
LQLSARARFW RSCVDGLRCL LSDRRVMLLG GVQALFESVL YIFVFLWTPV
310 320 330 340 350
LDPHGPPLGI VFSSLMAATM AGSTLFRLAT SAPYRLQPGH LLCLAILLAF
360 370 380 390 400
FSFFMLTFST VPGQPRPRES LLAFLLLELA CGLYFPAVSF LQGRVVPVER
410 420 430 440 450
RAAVLAWFRL PLHLLACLGL LALHGEVSGS GAGEAGSGTR HMFAGCAGMM
460 470 480
LAALLAVISL FTVGRNDADL RLEGPKLEGE I
Length:481
Mass (Da):52,789
Last modified:August 16, 2004 - v1
Checksum:i6F7E6E829C5E2900
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076536 mRNA. Translation: AAH76536.1.
RefSeqiNP_001002713.1. NM_001002713.1.
XP_005162430.1. XM_005162373.2.
XP_005162431.1. XM_005162374.2.
XP_009295316.1. XM_009297041.1.
XP_009295317.1. XM_009297042.1.
UniGeneiDr.30980.

Genome annotation databases

EnsembliENSDART00000011004; ENSDARP00000004281; ENSDARG00000015997.
GeneIDi436986.
KEGGidre:436986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076536 mRNA. Translation: AAH76536.1.
RefSeqiNP_001002713.1. NM_001002713.1.
XP_005162430.1. XM_005162373.2.
XP_005162431.1. XM_005162374.2.
XP_009295316.1. XM_009297041.1.
XP_009295317.1. XM_009297042.1.
UniGeneiDr.30980.

3D structure databases

ProteinModelPortaliQ6DG19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004281.

Protein family/group databases

TCDBi2.A.1.40.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiQ6DG19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000011004; ENSDARP00000004281; ENSDARG00000015997.
GeneIDi436986.
KEGGidre:436986.

Organism-specific databases

CTDi84975.
ZFINiZDB-GENE-040718-468. mfsd5.

Phylogenomic databases

eggNOGiKOG4332. Eukaryota.
ENOG410XSP5. LUCA.
GeneTreeiENSGT00390000012629.
HOGENOMiHOG000239662.
HOVERGENiHBG081970.
InParanoidiQ6DG19.
OMAiFESVLYI.
OrthoDBiEOG71ZP22.
PhylomeDBiQ6DG19.
TreeFamiTF328562.

Miscellaneous databases

NextBioi20831406.
PROiQ6DG19.

Gene expression databases

BgeeiQ6DG19.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR008509. MOT2/MFSD5.
[Graphical view]
PfamiPF05631. MFS_5. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiMFSD5_DANRE
AccessioniPrimary (citable) accession number: Q6DG19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: August 16, 2004
Last modified: January 20, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.