Q6DFX2 (ANTR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthrax toxin receptor 2

Gene names

Name:

Antxr2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Necessary for cellular interactions with laminin and the extracellular matrix By similarity.
Subunit structure	Binds laminin, and possibly also collagen type IV. Binds to the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner. Binding of PA leads to heptamerization of the receptor-PA complex By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Domain	Binding to PA seems to be effected through the VWA domain By similarity.
Sequence similarities	Belongs to the ATR family. Contains 1 VWFA domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	Metal-binding
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 31	31	Potential
	Chain	32 – 487	456	Anthrax toxin receptor 2		PRO_0000002695
Regions
	Topological domain	32 – 318	287	Extracellular Potential
	Transmembrane	319 – 339	21	Helical; Potential
	Topological domain	340 – 487	148	Cytoplasmic Potential
	Domain	44 – 213	170	VWFA
	Compositional bias	352 – 356	5	Poly-Pro
	Compositional bias	361 – 365	5	Poly-Glu
Sites
	Metal binding	52	1	Divalent metal cation By similarity
	Metal binding	54	1	Divalent metal cation By similarity
	Metal binding	118	1	Divalent metal cation By similarity
Amino acid modifications
	Modified residue	147	1	Phosphothreonine By similarity
	Glycosylation	260	1	N-linked (GlcNAc...) Potential
	Disulfide bond	39 ↔ 218		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6DFX2 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 61A400D60BC8DE69	FASTA	487	53,184
	10 20 30 40 50 60 MVAGRSRARS PGSWLFPGLW LLAVGGPGSL LQAQEQPSCK KAFDLYFVLD KSGSVANNWI 70 80 90 100 110 120 EIYNFVHQLT ERFVSPEMRL SFIVFSSQAT IILPLTGDRY KIGKGLEDLK AVKPVGETYI 130 140 150 160 170 180 HEGLKLANEQ IQNAGGLKAS SIIIALTDGK LDGLVPSYAE NEAKKSRSLG ASVYCVGVLD 190 200 210 220 230 240 FEQAQLERIA DSKDQVFPVK GGFQALKGII NSILAQSCTE ILELSPSSVC VGEKFQVVLT 250 260 270 280 290 300 GRAVTSISHD GSVLCTFTAN STYTKSEKPV SIQPSSILCP APVLNKDGET LEVSISYNDG 310 320 330 340 350 360 KSAVSRSLTI TATECTNGIA AIVAILVLLL LLGAALMWWF WPLCCKVVIK DPPPPPSAPM 370 380 390 400 410 420 EEEEEDPLPN KKWPTVDASY YGGRGVGGIK RMEVRWGDKG STEEGARLEK AKNAVVMVPE 430 440 450 460 470 480 EEIPIPSRPP RPRPTHQAPQ TKWYTPIKGR LDALWALIMK QYDRVSLMRP QEGDEGRCIN FSRVPHQ

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Eye and Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC003908 mRNA. Translation: AAH03908.1. BC076595 mRNA. Translation: AAH76595.1.
IPI	IPI00453488.
RefSeq	NP_598499.1. NM_133738.1.
UniGene	Mm.24842.
3D structure databases
ProteinModelPortal	Q6DFX2.
SMR	Q6DFX2. Positions 37-255.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6DFX2.
PTM databases
PhosphoSite	Q6DFX2.
Proteomic databases
PRIDE	Q6DFX2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000031281; ENSMUSP00000031281; ENSMUSG00000029338.
GeneID	71914.
KEGG	mmu:71914.
Organism-specific databases
CTD	118429.
MGI	MGI:1919164. Antxr2.
Phylogenomic databases
GeneTree	ENSGT00430000031214.
HOGENOM	HBG443624.
HOVERGEN	HBG050514.
InParanoid	Q6DFX2.
OMA	PTHQPPQ.
OrthoDB	EOG43BMP8.
PhylomeDB	Q6DFX2.
Gene expression databases
ArrayExpress	Q6DFX2.
Bgee	Q6DFX2.
CleanEx	MM_ANTXR2.
Genevestigator	Q6DFX2.
Family and domain databases
InterPro	IPR017360. Anthrax_toxin_rcpt. IPR008399. Anthrax_toxin_rcpt_C. IPR008400. Anthrax_toxin_rcpt_extracel. IPR002035. VWF_A. [Graphical view]
Pfam	PF05586. Ant_C. 1 hit. PF05587. Anth_Ig. 1 hit. PF00092. VWA. 1 hit. [Graphical view]
PIRSF	PIRSF038023. Anthrax_toxin_receptor_2. 1 hit.
ProDom	PD377005. Anthrax_toxin_rcpt_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00327. VWA. 1 hit. [Graphical view]
PROSITE	PS50234. VWFA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	334938.
SOURCE	Search...

Entry information

Entry name

ANTR2_MOUSE

Accession

Primary (citable) accession number: Q6DFX2
Secondary accession number(s): Q99L17

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 21, 2005
Last sequence update:	August 16, 2004
Last modified:	January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program