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Protein

Anthrax toxin receptor 2

Gene

Antxr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for cellular interactions with laminin and the extracellular matrix.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Divalent metal cationBy similarity1
Metal bindingi54Divalent metal cationBy similarity1
Metal bindingi118Divalent metal cationBy similarity1

GO - Molecular functioni

GO - Biological processi

  • reproductive process Source: MGI
  • toxin transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anthrax toxin receptor 2
Gene namesi
Name:Antxr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919164. Antxr2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 318ExtracellularSequence analysisAdd BLAST287
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 487CytoplasmicSequence analysisAdd BLAST148

GO - Cellular componenti

  • cell surface Source: MGI
  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000000269532 – 487Anthrax toxin receptor 2Add BLAST456

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 218By similarity
Modified residuei147PhosphothreonineBy similarity1
Glycosylationi260N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ6DFX2.
PaxDbiQ6DFX2.
PRIDEiQ6DFX2.

PTM databases

iPTMnetiQ6DFX2.
PhosphoSitePlusiQ6DFX2.
SwissPalmiQ6DFX2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029338.
CleanExiMM_ANTXR2.
ExpressionAtlasiQ6DFX2. baseline and differential.
GenevisibleiQ6DFX2. MM.

Interactioni

Subunit structurei

Binds laminin, and possibly also collagen type IV. Binds to the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner. Binding of PA leads to heptamerization of the receptor-PA complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031281.

Structurei

3D structure databases

ProteinModelPortaliQ6DFX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 213VWFAPROSITE-ProRule annotationAdd BLAST170

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi352 – 356Poly-Pro5
Compositional biasi361 – 365Poly-Glu5

Domaini

Binding to PA seems to be effected through the VWA domain.By similarity

Sequence similaritiesi

Belongs to the ATR family.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK1W. Eukaryota.
ENOG410YC57. LUCA.
GeneTreeiENSGT00430000031214.
HOGENOMiHOG000264249.
HOVERGENiHBG050514.
InParanoidiQ6DFX2.
PhylomeDBiQ6DFX2.
TreeFamiTF328943.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR017360. Anthrax_toxin_rcpt.
IPR008399. Anthrax_toxin_rcpt_C.
IPR008400. Anthrax_toxin_rcpt_extracel.
IPR002035. VWF_A.
[Graphical view]
PfamiPF05586. Ant_C. 1 hit.
PF05587. Anth_Ig. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PIRSFiPIRSF038023. Anthrax_toxin_receptor_2. 1 hit.
ProDomiPD377005. Anthrax_toxin_rcpt_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6DFX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAGRSRARS PGSWLFPGLW LLAVGGPGSL LQAQEQPSCK KAFDLYFVLD
60 70 80 90 100
KSGSVANNWI EIYNFVHQLT ERFVSPEMRL SFIVFSSQAT IILPLTGDRY
110 120 130 140 150
KIGKGLEDLK AVKPVGETYI HEGLKLANEQ IQNAGGLKAS SIIIALTDGK
160 170 180 190 200
LDGLVPSYAE NEAKKSRSLG ASVYCVGVLD FEQAQLERIA DSKDQVFPVK
210 220 230 240 250
GGFQALKGII NSILAQSCTE ILELSPSSVC VGEKFQVVLT GRAVTSISHD
260 270 280 290 300
GSVLCTFTAN STYTKSEKPV SIQPSSILCP APVLNKDGET LEVSISYNDG
310 320 330 340 350
KSAVSRSLTI TATECTNGIA AIVAILVLLL LLGAALMWWF WPLCCKVVIK
360 370 380 390 400
DPPPPPSAPM EEEEEDPLPN KKWPTVDASY YGGRGVGGIK RMEVRWGDKG
410 420 430 440 450
STEEGARLEK AKNAVVMVPE EEIPIPSRPP RPRPTHQAPQ TKWYTPIKGR
460 470 480
LDALWALIMK QYDRVSLMRP QEGDEGRCIN FSRVPHQ
Length:487
Mass (Da):53,184
Last modified:August 16, 2004 - v1
Checksum:i61A400D60BC8DE69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003908 mRNA. Translation: AAH03908.1.
BC076595 mRNA. Translation: AAH76595.1.
CCDSiCCDS39177.1.
RefSeqiNP_598499.1. NM_133738.1.
UniGeneiMm.24842.

Genome annotation databases

EnsembliENSMUST00000031281; ENSMUSP00000031281; ENSMUSG00000029338.
GeneIDi71914.
KEGGimmu:71914.
UCSCiuc008yga.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003908 mRNA. Translation: AAH03908.1.
BC076595 mRNA. Translation: AAH76595.1.
CCDSiCCDS39177.1.
RefSeqiNP_598499.1. NM_133738.1.
UniGeneiMm.24842.

3D structure databases

ProteinModelPortaliQ6DFX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031281.

PTM databases

iPTMnetiQ6DFX2.
PhosphoSitePlusiQ6DFX2.
SwissPalmiQ6DFX2.

Proteomic databases

MaxQBiQ6DFX2.
PaxDbiQ6DFX2.
PRIDEiQ6DFX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031281; ENSMUSP00000031281; ENSMUSG00000029338.
GeneIDi71914.
KEGGimmu:71914.
UCSCiuc008yga.1. mouse.

Organism-specific databases

CTDi118429.
MGIiMGI:1919164. Antxr2.

Phylogenomic databases

eggNOGiENOG410IK1W. Eukaryota.
ENOG410YC57. LUCA.
GeneTreeiENSGT00430000031214.
HOGENOMiHOG000264249.
HOVERGENiHBG050514.
InParanoidiQ6DFX2.
PhylomeDBiQ6DFX2.
TreeFamiTF328943.

Miscellaneous databases

ChiTaRSiAntxr2. mouse.
PROiQ6DFX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029338.
CleanExiMM_ANTXR2.
ExpressionAtlasiQ6DFX2. baseline and differential.
GenevisibleiQ6DFX2. MM.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR017360. Anthrax_toxin_rcpt.
IPR008399. Anthrax_toxin_rcpt_C.
IPR008400. Anthrax_toxin_rcpt_extracel.
IPR002035. VWF_A.
[Graphical view]
PfamiPF05586. Ant_C. 1 hit.
PF05587. Anth_Ig. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PIRSFiPIRSF038023. Anthrax_toxin_receptor_2. 1 hit.
ProDomiPD377005. Anthrax_toxin_rcpt_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANTR2_MOUSE
AccessioniPrimary (citable) accession number: Q6DFX2
Secondary accession number(s): Q99L17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.