ID   NCOA7_MOUSE             Reviewed;         943 AA.
AC   Q6DFV7; Q3TAR1; Q3UNB3; Q66K05; Q6ZQM4; Q8BJ15; Q8BJ39;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   27-MAR-2024, entry version 144.
DE   RecName: Full=Nuclear receptor coactivator 7;
GN   Name=Ncoa7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA   Ninomiya K., Wagatsuma M., Kanda K., Kondo H., Yokoi T., Kodaira H.,
RA   Furuya T., Takahashi M., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Sugiyama T., Irie R.,
RA   Otsuki T., Sato H., Ota T., Wakamatsu A., Ishii S., Yamamoto J., Isono Y.,
RA   Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H., Matsuo K.,
RA   Nakamura Y., Sekine M., Kikuchi H., Murakawa K., Kanehori K.,
RA   Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B., Suzuki Y.,
RA   Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T.;
RT   "NEDO cDNA sequencing project.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5).
RC   STRAIN=C57BL/6J; TISSUE=Colon, Lung, Spleen, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 6), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 19-943.
RC   STRAIN=C57BL/6J; TISSUE=Head, Kidney, and Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=11971969; DOI=10.1128/mcb.22.10.3358-3372.2002;
RA   Shao W., Halachmi S., Brown M.;
RT   "ERAP140, a conserved tissue-specific nuclear receptor coactivator.";
RL   Mol. Cell. Biol. 22:3358-3372(2002).
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92; SER-211; SER-212;
RP   SER-214; SER-498 AND SER-500, AND IDENTIFICATION BY MASS SPECTROMETRY
RP   [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Enhances the transcriptional activities of several nuclear
CC       receptors. Involved in the coactivation of different nuclear receptors,
CC       such as ESR1, THRB, PPARG and RARA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a
CC       ligand-inducible manner. Interacts with the heterodimer AHR-ARNT (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=6;
CC       Name=1;
CC         IsoId=Q6DFV7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6DFV7-2; Sequence=VSP_019641, VSP_019642;
CC       Name=3;
CC         IsoId=Q6DFV7-3; Sequence=VSP_019640, VSP_019643;
CC       Name=4;
CC         IsoId=Q6DFV7-4; Sequence=VSP_019640, VSP_019643, VSP_019648;
CC       Name=5;
CC         IsoId=Q6DFV7-5; Sequence=VSP_019640, VSP_019643, VSP_019644,
CC                                  VSP_019647;
CC       Name=6;
CC         IsoId=Q6DFV7-6; Sequence=VSP_019640, VSP_019643, VSP_019645,
CC                                  VSP_019646;
CC   -!- TISSUE SPECIFICITY: Highly expressed in brain and kidney. Weakly
CC       expressed in mammary gland, lung and testis. In brain, expression is
CC       found in neurons of cerebral cortex, thalamus, hypothalamus,
CC       hippocampus, cerebellum, striatum and choroid plexus.
CC       {ECO:0000269|PubMed:11971969}.
CC   -!- SIMILARITY: Belongs to the OXR1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC87660.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK128935; BAC87660.1; ALT_FRAME; mRNA.
DR   EMBL; AK033503; BAC28325.1; -; mRNA.
DR   EMBL; AK042369; BAC31241.1; -; mRNA.
DR   EMBL; AK144324; BAE25834.1; -; mRNA.
DR   EMBL; AK171679; BAE42607.1; -; mRNA.
DR   EMBL; BC049997; AAH49997.1; -; mRNA.
DR   EMBL; BC058572; AAH58572.1; -; mRNA.
DR   EMBL; BC076623; AAH76623.1; -; mRNA.
DR   EMBL; BC080670; AAH80670.1; -; mRNA.
DR   CCDS; CCDS23765.1; -. [Q6DFV7-1]
DR   CCDS; CCDS48530.1; -. [Q6DFV7-3]
DR   RefSeq; NP_001104737.1; NM_001111267.2. [Q6DFV7-3]
DR   RefSeq; NP_766083.3; NM_172495.5. [Q6DFV7-1]
DR   AlphaFoldDB; Q6DFV7; -.
DR   SMR; Q6DFV7; -.
DR   BioGRID; 229223; 9.
DR   STRING; 10090.ENSMUSP00000149335; -.
DR   iPTMnet; Q6DFV7; -.
DR   PhosphoSitePlus; Q6DFV7; -.
DR   SwissPalm; Q6DFV7; -.
DR   EPD; Q6DFV7; -.
DR   jPOST; Q6DFV7; -.
DR   MaxQB; Q6DFV7; -.
DR   PaxDb; 10090-ENSMUSP00000066741; -.
DR   PeptideAtlas; Q6DFV7; -.
DR   ProteomicsDB; 252653; -. [Q6DFV7-1]
DR   ProteomicsDB; 252654; -. [Q6DFV7-2]
DR   ProteomicsDB; 252655; -. [Q6DFV7-3]
DR   ProteomicsDB; 252656; -. [Q6DFV7-4]
DR   ProteomicsDB; 252657; -. [Q6DFV7-5]
DR   ProteomicsDB; 252658; -. [Q6DFV7-6]
DR   Pumba; Q6DFV7; -.
DR   Antibodypedia; 32708; 247 antibodies from 30 providers.
DR   DNASU; 211329; -.
DR   Ensembl; ENSMUST00000068567.5; ENSMUSP00000066741.5; ENSMUSG00000039697.17. [Q6DFV7-1]
DR   Ensembl; ENSMUST00000092610.12; ENSMUSP00000090273.6; ENSMUSG00000039697.17. [Q6DFV7-5]
DR   Ensembl; ENSMUST00000213897.2; ENSMUSP00000148944.2; ENSMUSG00000039697.17. [Q6DFV7-6]
DR   Ensembl; ENSMUST00000215725.2; ENSMUSP00000150800.2; ENSMUSG00000039697.17. [Q6DFV7-2]
DR   Ensembl; ENSMUST00000215740.2; ENSMUSP00000149335.2; ENSMUSG00000039697.17. [Q6DFV7-1]
DR   Ensembl; ENSMUST00000216172.2; ENSMUSP00000150981.2; ENSMUSG00000039697.17. [Q6DFV7-3]
DR   Ensembl; ENSMUST00000217644.2; ENSMUSP00000150671.2; ENSMUSG00000039697.17. [Q6DFV7-4]
DR   GeneID; 211329; -.
DR   KEGG; mmu:211329; -.
DR   UCSC; uc007etj.2; mouse. [Q6DFV7-5]
DR   UCSC; uc007etk.2; mouse. [Q6DFV7-1]
DR   UCSC; uc007etm.2; mouse. [Q6DFV7-4]
DR   UCSC; uc007eto.2; mouse. [Q6DFV7-2]
DR   AGR; MGI:2444847; -.
DR   CTD; 135112; -.
DR   MGI; MGI:2444847; Ncoa7.
DR   VEuPathDB; HostDB:ENSMUSG00000039697; -.
DR   eggNOG; KOG2372; Eukaryota.
DR   GeneTree; ENSGT00940000155141; -.
DR   HOGENOM; CLU_029204_4_1_1; -.
DR   InParanoid; Q6DFV7; -.
DR   OMA; IYLCRQQ; -.
DR   OrthoDB; 22028at2759; -.
DR   PhylomeDB; Q6DFV7; -.
DR   TreeFam; TF313530; -.
DR   BioGRID-ORCS; 211329; 2 hits in 74 CRISPR screens.
DR   ChiTaRS; Ncoa7; mouse.
DR   PRO; PR:Q6DFV7; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q6DFV7; Protein.
DR   Bgee; ENSMUSG00000039697; Expressed in uterine cervix and 218 other cell types or tissues.
DR   ExpressionAtlas; Q6DFV7; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016922; F:nuclear receptor binding; ISS:UniProtKB.
DR   GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR   GO; GO:1900408; P:negative regulation of cellular response to oxidative stress; IDA:MGI.
DR   GO; GO:1902083; P:negative regulation of peptidyl-cysteine S-nitrosylation; IDA:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR   Gene3D; 3.10.350.10; LysM domain; 1.
DR   InterPro; IPR018392; LysM_dom.
DR   InterPro; IPR036779; LysM_dom_sf.
DR   InterPro; IPR006571; TLDc_dom.
DR   PANTHER; PTHR23354:SF68; NUCLEAR RECEPTOR COACTIVATOR 7; 1.
DR   PANTHER; PTHR23354; NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED; 1.
DR   Pfam; PF01476; LysM; 1.
DR   Pfam; PF07534; TLD; 1.
DR   SMART; SM00257; LysM; 1.
DR   SMART; SM00584; TLDc; 1.
DR   SUPFAM; SSF54106; LysM domain; 1.
DR   PROSITE; PS51782; LYSM; 1.
DR   PROSITE; PS51886; TLDC; 1.
DR   Genevisible; Q6DFV7; MM.
PE   1: Evidence at protein level;
KW   Acetylation; Activator; Alternative splicing; Coiled coil; Nucleus;
KW   Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..943
FT                   /note="Nuclear receptor coactivator 7"
FT                   /id="PRO_0000245230"
FT   DOMAIN          117..160
FT                   /note="LysM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT   DOMAIN          782..943
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          169..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          543..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..32
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..83
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..366
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        486..500
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NI08"
FT   MOD_RES         92
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         137
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NI08"
FT   MOD_RES         182
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NI08"
FT   MOD_RES         186
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NI08"
FT   MOD_RES         211
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         212
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         214
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         442
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NI08"
FT   MOD_RES         498
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   MOD_RES         500
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   VAR_SEQ         1..722
FT                   /note="Missing (in isoform 3, isoform 4, isoform 5 and
FT                   isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16141072"
FT                   /id="VSP_019640"
FT   VAR_SEQ         237..271
FT                   /note="GVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGL -> VSATVIAYWSGNL
FT                   QKLNKKTHCWMGVFYPQLKCMI (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_019641"
FT   VAR_SEQ         272..943
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_019642"
FT   VAR_SEQ         723..747
FT                   /note="FVVVEKEELNMIDNFFSEPTTKSWE -> MRGRGLPLDIQIFYCARPDQEPF
FT                   VK (in isoform 3, isoform 4, isoform 5 and isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16141072"
FT                   /id="VSP_019643"
FT   VAR_SEQ         875..883
FT                   /note="VFKWSGENS -> GTIWSVARC (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_019644"
FT   VAR_SEQ         875..881
FT                   /note="VFKWSGE -> PISHLGH (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_019645"
FT   VAR_SEQ         882..943
FT                   /note="Missing (in isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_019646"
FT   VAR_SEQ         884..943
FT                   /note="Missing (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_019647"
FT   VAR_SEQ         900..943
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_019648"
SQ   SEQUENCE   943 AA;  106357 MW;  872D551ACEEE5109 CRC64;
     MDTKEEKKEQ KERKQSYFAR LKKKKQAKQN AEIVSAASSK SRSGKDDANS DILEQDKFNV
     TAEGDHSTDD KKKRKSNQLK EIRRTELKRY YSVDDNQNKT HDKKEKKMMV QKPQGTMEYT
     AGSQDTLNSV ALKFNVTPNK LVELNKLFTH TIVPGQVLFV PDANISSSTI QLSSSTPGAT
     VSPSSSDAEY DKLPDADLAR KALKPIERVL SSTSEEDEPG VVKFLKMNCR YFTDGKGVVG
     GVMIVTPNNI MFDPHKSDPL VIENGCEEYG LICPMEEVVS IALYSDISHM KIKDALPSDL
     PRDLCPLYRP GEWEDLASEK DINPFSKFKS INKEKRQQNG ERTLALDAKS VRSPEESTER
     TCTRIEPPDN SELWKLKNLQ SSRGTTSESP SVTQLSMRAA LEPTAKENCL LKGDEDFVDL
     EELSSQPESG INKGDATKEC LSYDQKKDGP HTVMSAKKGH VQSAQEVMGP ESDTELKGAL
     DLETAEKQDE APEVDKHSGS PENLGESTLN IHEDLDKIKL IEFYLNKNKE GSQLLENVQK
     SELSDRKSIE PGGIDITLSS SLPQAGDSPP EDNKEPGTLW VKGGETLPLK LDPSAEETVI
     NNKEVLDSLG SSLDKMCHSA QMDNKSEIQL WLLKRIQVPI EDILPSKEEK SKTPPMFLCI
     KVGKPMRKSF ASHTATMVQQ YSKRRKQPEY WFAVPRERVD HLYTFFVQWS PDVYGKDAKE
     QGFVVVEKEE LNMIDNFFSE PTTKSWEIIT VEEAKRRKST CSYYEEEEEE EEGLPILQPH
     SALLENMHIE QLARRLPARV QGYPWRLAYS TLEHGTSLKT LYRKSASLDS PVLLVIKDMD
     NQIFGAYATH PFKFSDHYYG TGETFLYTFS PNFKVFKWSG ENSYFINGDI SSLELGGGGG
     RFGLWLDADL YHGRSNSCST FNNDILSKKE DFIVQDLEVW TFE
//