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Q6DFV5

- HELZ_MOUSE

UniProt

Q6DFV5 - HELZ_MOUSE

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Protein

Probable helicase with zinc finger domain

Gene

Helz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri178 – 20629C3H1-typePROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi668 – 6758ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. poly(A) RNA binding Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable helicase with zinc finger domain (EC:3.6.4.-)
Gene namesi
Name:Helz
Synonyms:Kiaa0054
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1925705. Helz.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19641964Probable helicase with zinc finger domainPRO_0000354096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1636 – 16361PhosphoserineBy similarity
Modified residuei1760 – 17601PhosphoserineBy similarity
Modified residuei1788 – 17881PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6DFV5.
PaxDbiQ6DFV5.
PRIDEiQ6DFV5.

PTM databases

PhosphoSiteiQ6DFV5.

Expressioni

Gene expression databases

BgeeiQ6DFV5.
ExpressionAtlasiQ6DFV5. baseline and differential.
GenevestigatoriQ6DFV5.

Interactioni

Subunit structurei

Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II (By similarity). Interacts with SMYD2.By similarity1 Publication

Protein-protein interaction databases

BioGridi219414. 3 interactions.
IntActiQ6DFV5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6DFV5.
SMRiQ6DFV5. Positions 642-1050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi794 – 7974DEAA box

Sequence similaritiesi

Belongs to the DNA2/NAM7 helicase family.Curated
Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri178 – 20629C3H1-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1112.
GeneTreeiENSGT00550000074391.
HOGENOMiHOG000231202.
HOVERGENiHBG031603.
InParanoidiQ6DFV5.
PhylomeDBiQ6DFV5.
TreeFamiTF323999.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6DFV5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDRRAERSC EQACASLQRQ DYDMALQHCT DALLSLGQYS MADFTGPCPV
60 70 80 90 100
EVERIKIESL LYRIASFLQL KNYGQADEDC RHVLGEGLAK GERAFRAVLC
110 120 130 140 150
CMQLKGKLQL VSSILAKSLS GESLNGMVTK DLTRLKTLLT ETETATSNVL
160 170 180 190 200
SGCHVEDLDE GSCNGWHFRP PPRGITSSEE YTLCKRFLEQ GICRYGAQCT
210 220 230 240 250
SAHSQEELAE WQKRYASRLI KLKQQSENKQ LSGSYMETLI EKWMSSLSPE
260 270 280 290 300
KVLSECIEGV QVEHSPDLSV TVNTKKSHQT WTFALTCKPA RMLYRVALLY
310 320 330 340 350
DAHRPHFSII AISAGDSTTQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG
360 370 380 390 400
IAFNTEIFGT FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKRQLV
410 420 430 440 450
TTAKRWDSSS KTIVDFEPNE TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS
460 470 480 490 500
LTKTNYQARL HDLLYIEEIA QYKEVSRFNL KVQLQILASF MLTGVSGGAK
510 520 530 540 550
YAQNGQLFGR FKLTETLSED TLAGRLVMTR VNAVYLLPVP KEKLVQSQGT
560 570 580 590 600
KEKVYEATIE EKTKDYVFLR ISRECCEELS LRPDCDIQVE LQFQLNRLPL
610 620 630 640 650
CEMHYALDRI KDNAVLFPDI SMTPTIPWSP NRQWDEQLDP RLNAKQKEAV
660 670 680 690 700
LAITTPLSIQ LPPVLIIGPY GTGKTFTLAQ AAKHILQQQE TRILICTHSN
710 720 730 740 750
SAADLYIKDY LHPYVEAGNP QARPLRVYFR NRWVKTVHPV VHQYCLISST
760 770 780 790 800
QSTFQMPQKE DILKHRVVVV TLSTSQYLCQ LDLEPGFFTH VLLDEAAQAM
810 820 830 840 850
ECETIMPLAL ATKNTRIVLA GDHMQLSPFV YSEFARERNL HVSLLDRLYE
860 870 880 890 900
HYPAEFPCRI LLCENYRSHE AIINYTSELF YEGKLMASGK QPAHKDFYPL
910 920 930 940 950
TFFTARGEDV QEKNSTAFYN NAEVFEVVER VEELRRKWPV AWGKLDDGSI
960 970 980 990 1000
GVVTPYADQV FRIRAELRKK RLSDVNVERV LNVQGKQFRV LFLSTVRTRH
1010 1020 1030 1040 1050
TCKHKQTPIK KKEQLLEDST EDLDYGFLSN YKLLNTAITR AQSLVAVVGD
1060 1070 1080 1090 1100
PVALCSIGRC RKFWERFIAL CHENHSLHGI TFEQIKAQLE ALELKKTYVL
1110 1120 1130 1140 1150
NPLAPEFIPR ALRLQHSGNS SRQQQSPPKV KSLYHPQSDH FQSDGIVQPN
1160 1170 1180 1190 1200
PSVLIGNPIR AYTPPPPLGP HPNLGKSPSP VQRIDPHTGT SILYVPAVYG
1210 1220 1230 1240 1250
GNVVMSVPLP VPWTGYQGRF AVDPRIITHQ AAMAYNMNLL HTHGRGSPIP
1260 1270 1280 1290 1300
YGLGHHPPVS LGQPQSQHAE KDQQEQNRNG KTDTNNPGPE INKIRTPEKK
1310 1320 1330 1340 1350
PTEPKQVDLE SNPQNRSPES RPGVVYSNTK FPRKDHLNPR HINNLPLPAP
1360 1370 1380 1390 1400
HAQYAIPSRH FHPLPQLPRP PFPASQPHTL LNQQQNNLPE QPNQMAPQPN
1410 1420 1430 1440 1450
QVAPQPNQMT PQPNQVAPQP NQVVQQQSQA PPQAPQPAPQ LSPAFQAGPT
1460 1470 1480 1490 1500
NAFFNNAVAH RPQSPAAEAV GPEQPPPPGL PDGHSPLRAI TQPGPILASP
1510 1520 1530 1540 1550
LNNFVDESSP GLPIEEALDG VHGSVALETL RQQQARLQQW SEHHAYLSQG
1560 1570 1580 1590 1600
GIPYSHHHHP HLPHLPHTPI GLHQPPVRAE WKVAGRADDE TETTFSRFQD
1610 1620 1630 1640 1650
LLRELSHRDQ GDTGELAEMP PPQSRLLQYR QVQPRSPPAV PSPPSSTDHS
1660 1670 1680 1690 1700
SQFANFNDSS RDIEVANSPA FPQRLPPQLF GSPFSLPSEH LAPPPLKYLA
1710 1720 1730 1740 1750
PEGAWNFANL QQNHLIGPGF PYGLPPLPPR PPQNPFIHIQ NHQHAAGQEP
1760 1770 1780 1790 1800
FHPLSSRTVS ASSLPSLEEY EPRGPGRPLY QRRISSSSAQ PCVEEASAPQ
1810 1820 1830 1840 1850
DSLAQGKESQ GHSNPPAFNF PAPESWANTT SSAPYQNIPC NGSSRTSQPR
1860 1870 1880 1890 1900
ELIAPPKTVK PPEDQLKPES GEVSSSFNYS MLQHLGQFPP LMPNKQIAES
1910 1920 1930 1940 1950
ANCSSQQSPA GSKPAMSYAS ALRAPPKPRP PPEQAKKGSD PLSLLQELSL
1960
GSSPGSNGFY SYFK
Length:1,964
Mass (Da):219,880
Last modified:November 25, 2008 - v2
Checksum:iBED050BC57CFE065
GO
Isoform 2 (identifier: Q6DFV5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1598-1616: FQDLLRELSHRDQGDTGEL → YSSRPGPALITTCVWSA
     1617-1964: Missing.

Show »
Length:1,614
Mass (Da):181,841
Checksum:i6E5AF1AB37743D2E
GO
Isoform 3 (identifier: Q6DFV5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     690-690: E → ET

Show »
Length:1,965
Mass (Da):219,981
Checksum:i5AE327003458D904
GO

Sequence cautioni

The sequence BAC41393.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti963 – 9631I → T in BAC28150. (PubMed:16141072)Curated
Sequence conflicti1193 – 11931L → P in BAC28150. (PubMed:16141072)Curated
Sequence conflicti1496 – 14961I → N in BAC28150. (PubMed:16141072)Curated
Sequence conflicti1746 – 17461A → V in AAH21818. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei690 – 6901E → ET in isoform 3. 1 PublicationVSP_035795
Alternative sequencei1598 – 161619FQDLL…DTGEL → YSSRPGPALITTCVWSA in isoform 2. 1 PublicationVSP_035796Add
BLAST
Alternative sequencei1617 – 1964348Missing in isoform 2. 1 PublicationVSP_035797Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093209 mRNA. Translation: BAC41393.1. Different initiation.
AL645947 Genomic DNA. Translation: CAM21447.1.
BC021818 mRNA. Translation: AAH21818.1.
BC076626 mRNA. Translation: AAH76626.1.
BC130582 mRNA. Translation: AAI30583.1.
AK033094 mRNA. Translation: BAC28150.1.
CCDSiCCDS25569.1. [Q6DFV5-3]
RefSeqiNP_938040.1. NM_198298.1.
XP_006534567.1. XM_006534504.1.
XP_006534568.1. XM_006534505.1.
XP_006534569.1. XM_006534506.1.
XP_006534570.1. XM_006534507.1. [Q6DFV5-1]
UniGeneiMm.272047.
Mm.394603.
Mm.490425.

Genome annotation databases

EnsembliENSMUST00000075012; ENSMUSP00000074533; ENSMUSG00000020721.
ENSMUST00000106746; ENSMUSP00000102357; ENSMUSG00000020721. [Q6DFV5-1]
GeneIDi78455.
KEGGimmu:78455.
UCSCiuc007mav.1. mouse. [Q6DFV5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB093209 mRNA. Translation: BAC41393.1 . Different initiation.
AL645947 Genomic DNA. Translation: CAM21447.1 .
BC021818 mRNA. Translation: AAH21818.1 .
BC076626 mRNA. Translation: AAH76626.1 .
BC130582 mRNA. Translation: AAI30583.1 .
AK033094 mRNA. Translation: BAC28150.1 .
CCDSi CCDS25569.1. [Q6DFV5-3 ]
RefSeqi NP_938040.1. NM_198298.1.
XP_006534567.1. XM_006534504.1.
XP_006534568.1. XM_006534505.1.
XP_006534569.1. XM_006534506.1.
XP_006534570.1. XM_006534507.1. [Q6DFV5-1 ]
UniGenei Mm.272047.
Mm.394603.
Mm.490425.

3D structure databases

ProteinModelPortali Q6DFV5.
SMRi Q6DFV5. Positions 642-1050.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 219414. 3 interactions.
IntActi Q6DFV5. 1 interaction.

PTM databases

PhosphoSitei Q6DFV5.

Proteomic databases

MaxQBi Q6DFV5.
PaxDbi Q6DFV5.
PRIDEi Q6DFV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075012 ; ENSMUSP00000074533 ; ENSMUSG00000020721 .
ENSMUST00000106746 ; ENSMUSP00000102357 ; ENSMUSG00000020721 . [Q6DFV5-1 ]
GeneIDi 78455.
KEGGi mmu:78455.
UCSCi uc007mav.1. mouse. [Q6DFV5-3 ]

Organism-specific databases

CTDi 9931.
MGIi MGI:1925705. Helz.
Rougei Search...

Phylogenomic databases

eggNOGi COG1112.
GeneTreei ENSGT00550000074391.
HOGENOMi HOG000231202.
HOVERGENi HBG031603.
InParanoidi Q6DFV5.
PhylomeDBi Q6DFV5.
TreeFami TF323999.

Miscellaneous databases

ChiTaRSi Helz. mouse.
NextBioi 348914.
PROi Q6DFV5.
SOURCEi Search...

Gene expression databases

Bgeei Q6DFV5.
ExpressionAtlasi Q6DFV5. baseline and differential.
Genevestigatori Q6DFV5.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000571. Znf_CCCH.
[Graphical view ]
Pfami PF00642. zf-CCCH. 1 hit.
[Graphical view ]
SMARTi SM00356. ZnF_C3H1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50103. ZF_C3H1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6 and Czech II.
    Tissue: Brain, Head and Mammary tumor.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 750-1964.
    Strain: C57BL/6J.
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: INTERACTION WITH SMYD2.

Entry informationi

Entry nameiHELZ_MOUSE
AccessioniPrimary (citable) accession number: Q6DFV5
Secondary accession number(s): A1L4L4
, A2AAU4, Q8BZZ6, Q8CHI3, Q8VDI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: November 26, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3