Q6DFV5 (HELZ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable helicase with zinc finger domain
EC=3.6.4.-

Gene names

Name:	Helz
Synonyms:	Kiaa0054

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1964 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo By similarity.
Subunit structure	Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II By similarity. Interacts with SMYD2. Ref.6
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the DNA2/NAM7 helicase family. Contains 1 C3H1-type zinc finger.
Sequence caution	The sequence BAC41393.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Helicase Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW helicase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6DFV5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6DFV5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1598-1616: FQDLLRELSHRDQGDTGEL → YSSRPGPALITTCVWSA
     1617-1964: Missing.

Isoform 3 (identifier: Q6DFV5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     690-690: E → ET

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1964	1964	Probable helicase with zinc finger domain		PRO_0000354096
Regions
	Zinc finger	178 – 206	29	C3H1-type
	Nucleotide binding	668 – 675	8	ATP Potential
	Motif	794 – 797	4	DEAA box
Amino acid modifications
	Modified residue	1636	1	Phosphoserine By similarity
	Modified residue	1760	1	Phosphoserine By similarity
	Modified residue	1788	1	Phosphoserine Ref.5
Natural variations
	Alternative sequence	690	1	E → ET in isoform 3.		VSP_035795
	Alternative sequence	1598 – 1616	19	FQDLL…DTGEL → YSSRPGPALITTCVWSA in isoform 2.		VSP_035796
	Alternative sequence	1617 – 1964	348	Missing in isoform 2.		VSP_035797
Experimental info
	Sequence conflict	963	1	I → T in BAC28150. Ref.4
	Sequence conflict	1193	1	L → P in BAC28150. Ref.4
	Sequence conflict	1496	1	I → N in BAC28150. Ref.4
	Sequence conflict	1746	1	A → V in AAH21818. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: BED050BC57CFE065	FASTA	1,964	219,880
	10 20 30 40 50 60 MEDRRAERSC EQACASLQRQ DYDMALQHCT DALLSLGQYS MADFTGPCPV EVERIKIESL 70 80 90 100 110 120 LYRIASFLQL KNYGQADEDC RHVLGEGLAK GERAFRAVLC CMQLKGKLQL VSSILAKSLS 130 140 150 160 170 180 GESLNGMVTK DLTRLKTLLT ETETATSNVL SGCHVEDLDE GSCNGWHFRP PPRGITSSEE 190 200 210 220 230 240 YTLCKRFLEQ GICRYGAQCT SAHSQEELAE WQKRYASRLI KLKQQSENKQ LSGSYMETLI 250 260 270 280 290 300 EKWMSSLSPE KVLSECIEGV QVEHSPDLSV TVNTKKSHQT WTFALTCKPA RMLYRVALLY 310 320 330 340 350 360 DAHRPHFSII AISAGDSTTQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG IAFNTEIFGT 370 380 390 400 410 420 FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKRQLV TTAKRWDSSS KTIVDFEPNE 430 440 450 460 470 480 TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS LTKTNYQARL HDLLYIEEIA QYKEVSRFNL 490 500 510 520 530 540 KVQLQILASF MLTGVSGGAK YAQNGQLFGR FKLTETLSED TLAGRLVMTR VNAVYLLPVP 550 560 570 580 590 600 KEKLVQSQGT KEKVYEATIE EKTKDYVFLR ISRECCEELS LRPDCDIQVE LQFQLNRLPL 610 620 630 640 650 660 CEMHYALDRI KDNAVLFPDI SMTPTIPWSP NRQWDEQLDP RLNAKQKEAV LAITTPLSIQ 670 680 690 700 710 720 LPPVLIIGPY GTGKTFTLAQ AAKHILQQQE TRILICTHSN SAADLYIKDY LHPYVEAGNP 730 740 750 760 770 780 QARPLRVYFR NRWVKTVHPV VHQYCLISST QSTFQMPQKE DILKHRVVVV TLSTSQYLCQ 790 800 810 820 830 840 LDLEPGFFTH VLLDEAAQAM ECETIMPLAL ATKNTRIVLA GDHMQLSPFV YSEFARERNL 850 860 870 880 890 900 HVSLLDRLYE HYPAEFPCRI LLCENYRSHE AIINYTSELF YEGKLMASGK QPAHKDFYPL 910 920 930 940 950 960 TFFTARGEDV QEKNSTAFYN NAEVFEVVER VEELRRKWPV AWGKLDDGSI GVVTPYADQV 970 980 990 1000 1010 1020 FRIRAELRKK RLSDVNVERV LNVQGKQFRV LFLSTVRTRH TCKHKQTPIK KKEQLLEDST 1030 1040 1050 1060 1070 1080 EDLDYGFLSN YKLLNTAITR AQSLVAVVGD PVALCSIGRC RKFWERFIAL CHENHSLHGI 1090 1100 1110 1120 1130 1140 TFEQIKAQLE ALELKKTYVL NPLAPEFIPR ALRLQHSGNS SRQQQSPPKV KSLYHPQSDH 1150 1160 1170 1180 1190 1200 FQSDGIVQPN PSVLIGNPIR AYTPPPPLGP HPNLGKSPSP VQRIDPHTGT SILYVPAVYG 1210 1220 1230 1240 1250 1260 GNVVMSVPLP VPWTGYQGRF AVDPRIITHQ AAMAYNMNLL HTHGRGSPIP YGLGHHPPVS 1270 1280 1290 1300 1310 1320 LGQPQSQHAE KDQQEQNRNG KTDTNNPGPE INKIRTPEKK PTEPKQVDLE SNPQNRSPES 1330 1340 1350 1360 1370 1380 RPGVVYSNTK FPRKDHLNPR HINNLPLPAP HAQYAIPSRH FHPLPQLPRP PFPASQPHTL 1390 1400 1410 1420 1430 1440 LNQQQNNLPE QPNQMAPQPN QVAPQPNQMT PQPNQVAPQP NQVVQQQSQA PPQAPQPAPQ 1450 1460 1470 1480 1490 1500 LSPAFQAGPT NAFFNNAVAH RPQSPAAEAV GPEQPPPPGL PDGHSPLRAI TQPGPILASP 1510 1520 1530 1540 1550 1560 LNNFVDESSP GLPIEEALDG VHGSVALETL RQQQARLQQW SEHHAYLSQG GIPYSHHHHP 1570 1580 1590 1600 1610 1620 HLPHLPHTPI GLHQPPVRAE WKVAGRADDE TETTFSRFQD LLRELSHRDQ GDTGELAEMP 1630 1640 1650 1660 1670 1680 PPQSRLLQYR QVQPRSPPAV PSPPSSTDHS SQFANFNDSS RDIEVANSPA FPQRLPPQLF 1690 1700 1710 1720 1730 1740 GSPFSLPSEH LAPPPLKYLA PEGAWNFANL QQNHLIGPGF PYGLPPLPPR PPQNPFIHIQ 1750 1760 1770 1780 1790 1800 NHQHAAGQEP FHPLSSRTVS ASSLPSLEEY EPRGPGRPLY QRRISSSSAQ PCVEEASAPQ 1810 1820 1830 1840 1850 1860 DSLAQGKESQ GHSNPPAFNF PAPESWANTT SSAPYQNIPC NGSSRTSQPR ELIAPPKTVK 1870 1880 1890 1900 1910 1920 PPEDQLKPES GEVSSSFNYS MLQHLGQFPP LMPNKQIAES ANCSSQQSPA GSKPAMSYAS 1930 1940 1950 1960 ALRAPPKPRP PPEQAKKGSD PLSLLQELSL GSSPGSNGFY SYFK
	Isoform 2 [UniParc]. Checksum: 6E5AF1AB37743D2E	FASTA	1,614	181,841
	10 20 30 40 50 60 MEDRRAERSC EQACASLQRQ DYDMALQHCT DALLSLGQYS MADFTGPCPV EVERIKIESL 70 80 90 100 110 120 LYRIASFLQL KNYGQADEDC RHVLGEGLAK GERAFRAVLC CMQLKGKLQL VSSILAKSLS 130 140 150 160 170 180 GESLNGMVTK DLTRLKTLLT ETETATSNVL SGCHVEDLDE GSCNGWHFRP PPRGITSSEE 190 200 210 220 230 240 YTLCKRFLEQ GICRYGAQCT SAHSQEELAE WQKRYASRLI KLKQQSENKQ LSGSYMETLI 250 260 270 280 290 300 EKWMSSLSPE KVLSECIEGV QVEHSPDLSV TVNTKKSHQT WTFALTCKPA RMLYRVALLY 310 320 330 340 350 360 DAHRPHFSII AISAGDSTTQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG IAFNTEIFGT 370 380 390 400 410 420 FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKRQLV TTAKRWDSSS KTIVDFEPNE 430 440 450 460 470 480 TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS LTKTNYQARL HDLLYIEEIA QYKEVSRFNL 490 500 510 520 530 540 KVQLQILASF MLTGVSGGAK YAQNGQLFGR FKLTETLSED TLAGRLVMTR VNAVYLLPVP 550 560 570 580 590 600 KEKLVQSQGT KEKVYEATIE EKTKDYVFLR ISRECCEELS LRPDCDIQVE LQFQLNRLPL 610 620 630 640 650 660 CEMHYALDRI KDNAVLFPDI SMTPTIPWSP NRQWDEQLDP RLNAKQKEAV LAITTPLSIQ 670 680 690 700 710 720 LPPVLIIGPY GTGKTFTLAQ AAKHILQQQE TRILICTHSN SAADLYIKDY LHPYVEAGNP 730 740 750 760 770 780 QARPLRVYFR NRWVKTVHPV VHQYCLISST QSTFQMPQKE DILKHRVVVV TLSTSQYLCQ 790 800 810 820 830 840 LDLEPGFFTH VLLDEAAQAM ECETIMPLAL ATKNTRIVLA GDHMQLSPFV YSEFARERNL 850 860 870 880 890 900 HVSLLDRLYE HYPAEFPCRI LLCENYRSHE AIINYTSELF YEGKLMASGK QPAHKDFYPL 910 920 930 940 950 960 TFFTARGEDV QEKNSTAFYN NAEVFEVVER VEELRRKWPV AWGKLDDGSI GVVTPYADQV 970 980 990 1000 1010 1020 FRIRAELRKK RLSDVNVERV LNVQGKQFRV LFLSTVRTRH TCKHKQTPIK KKEQLLEDST 1030 1040 1050 1060 1070 1080 EDLDYGFLSN YKLLNTAITR AQSLVAVVGD PVALCSIGRC RKFWERFIAL CHENHSLHGI 1090 1100 1110 1120 1130 1140 TFEQIKAQLE ALELKKTYVL NPLAPEFIPR ALRLQHSGNS SRQQQSPPKV KSLYHPQSDH 1150 1160 1170 1180 1190 1200 FQSDGIVQPN PSVLIGNPIR AYTPPPPLGP HPNLGKSPSP VQRIDPHTGT SILYVPAVYG 1210 1220 1230 1240 1250 1260 GNVVMSVPLP VPWTGYQGRF AVDPRIITHQ AAMAYNMNLL HTHGRGSPIP YGLGHHPPVS 1270 1280 1290 1300 1310 1320 LGQPQSQHAE KDQQEQNRNG KTDTNNPGPE INKIRTPEKK PTEPKQVDLE SNPQNRSPES 1330 1340 1350 1360 1370 1380 RPGVVYSNTK FPRKDHLNPR HINNLPLPAP HAQYAIPSRH FHPLPQLPRP PFPASQPHTL 1390 1400 1410 1420 1430 1440 LNQQQNNLPE QPNQMAPQPN QVAPQPNQMT PQPNQVAPQP NQVVQQQSQA PPQAPQPAPQ 1450 1460 1470 1480 1490 1500 LSPAFQAGPT NAFFNNAVAH RPQSPAAEAV GPEQPPPPGL PDGHSPLRAI TQPGPILASP 1510 1520 1530 1540 1550 1560 LNNFVDESSP GLPIEEALDG VHGSVALETL RQQQARLQQW SEHHAYLSQG GIPYSHHHHP 1570 1580 1590 1600 1610 HLPHLPHTPI GLHQPPVRAE WKVAGRADDE TETTFSRYSS RPGPALITTC VWSA
	Isoform 3 [UniParc]. Checksum: 5AE327003458D904	FASTA	1,965	219,981
	10 20 30 40 50 60 MEDRRAERSC EQACASLQRQ DYDMALQHCT DALLSLGQYS MADFTGPCPV EVERIKIESL 70 80 90 100 110 120 LYRIASFLQL KNYGQADEDC RHVLGEGLAK GERAFRAVLC CMQLKGKLQL VSSILAKSLS 130 140 150 160 170 180 GESLNGMVTK DLTRLKTLLT ETETATSNVL SGCHVEDLDE GSCNGWHFRP PPRGITSSEE 190 200 210 220 230 240 YTLCKRFLEQ GICRYGAQCT SAHSQEELAE WQKRYASRLI KLKQQSENKQ LSGSYMETLI 250 260 270 280 290 300 EKWMSSLSPE KVLSECIEGV QVEHSPDLSV TVNTKKSHQT WTFALTCKPA RMLYRVALLY 310 320 330 340 350 360 DAHRPHFSII AISAGDSTTQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG IAFNTEIFGT 370 380 390 400 410 420 FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKRQLV TTAKRWDSSS KTIVDFEPNE 430 440 450 460 470 480 TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS LTKTNYQARL HDLLYIEEIA QYKEVSRFNL 490 500 510 520 530 540 KVQLQILASF MLTGVSGGAK YAQNGQLFGR FKLTETLSED TLAGRLVMTR VNAVYLLPVP 550 560 570 580 590 600 KEKLVQSQGT KEKVYEATIE EKTKDYVFLR ISRECCEELS LRPDCDIQVE LQFQLNRLPL 610 620 630 640 650 660 CEMHYALDRI KDNAVLFPDI SMTPTIPWSP NRQWDEQLDP RLNAKQKEAV LAITTPLSIQ 670 680 690 700 710 720 LPPVLIIGPY GTGKTFTLAQ AAKHILQQQE TTRILICTHS NSAADLYIKD YLHPYVEAGN 730 740 750 760 770 780 PQARPLRVYF RNRWVKTVHP VVHQYCLISS TQSTFQMPQK EDILKHRVVV VTLSTSQYLC 790 800 810 820 830 840 QLDLEPGFFT HVLLDEAAQA MECETIMPLA LATKNTRIVL AGDHMQLSPF VYSEFARERN 850 860 870 880 890 900 LHVSLLDRLY EHYPAEFPCR ILLCENYRSH EAIINYTSEL FYEGKLMASG KQPAHKDFYP 910 920 930 940 950 960 LTFFTARGED VQEKNSTAFY NNAEVFEVVE RVEELRRKWP VAWGKLDDGS IGVVTPYADQ 970 980 990 1000 1010 1020 VFRIRAELRK KRLSDVNVER VLNVQGKQFR VLFLSTVRTR HTCKHKQTPI KKKEQLLEDS 1030 1040 1050 1060 1070 1080 TEDLDYGFLS NYKLLNTAIT RAQSLVAVVG DPVALCSIGR CRKFWERFIA LCHENHSLHG 1090 1100 1110 1120 1130 1140 ITFEQIKAQL EALELKKTYV LNPLAPEFIP RALRLQHSGN SSRQQQSPPK VKSLYHPQSD 1150 1160 1170 1180 1190 1200 HFQSDGIVQP NPSVLIGNPI RAYTPPPPLG PHPNLGKSPS PVQRIDPHTG TSILYVPAVY 1210 1220 1230 1240 1250 1260 GGNVVMSVPL PVPWTGYQGR FAVDPRIITH QAAMAYNMNL LHTHGRGSPI PYGLGHHPPV 1270 1280 1290 1300 1310 1320 SLGQPQSQHA EKDQQEQNRN GKTDTNNPGP EINKIRTPEK KPTEPKQVDL ESNPQNRSPE 1330 1340 1350 1360 1370 1380 SRPGVVYSNT KFPRKDHLNP RHINNLPLPA PHAQYAIPSR HFHPLPQLPR PPFPASQPHT 1390 1400 1410 1420 1430 1440 LLNQQQNNLP EQPNQMAPQP NQVAPQPNQM TPQPNQVAPQ PNQVVQQQSQ APPQAPQPAP 1450 1460 1470 1480 1490 1500 QLSPAFQAGP TNAFFNNAVA HRPQSPAAEA VGPEQPPPPG LPDGHSPLRA ITQPGPILAS 1510 1520 1530 1540 1550 1560 PLNNFVDESS PGLPIEEALD GVHGSVALET LRQQQARLQQ WSEHHAYLSQ GGIPYSHHHH 1570 1580 1590 1600 1610 1620 PHLPHLPHTP IGLHQPPVRA EWKVAGRADD ETETTFSRFQ DLLRELSHRD QGDTGELAEM 1630 1640 1650 1660 1670 1680 PPPQSRLLQY RQVQPRSPPA VPSPPSSTDH SSQFANFNDS SRDIEVANSP AFPQRLPPQL 1690 1700 1710 1720 1730 1740 FGSPFSLPSE HLAPPPLKYL APEGAWNFAN LQQNHLIGPG FPYGLPPLPP RPPQNPFIHI 1750 1760 1770 1780 1790 1800 QNHQHAAGQE PFHPLSSRTV SASSLPSLEE YEPRGPGRPL YQRRISSSSA QPCVEEASAP 1810 1820 1830 1840 1850 1860 QDSLAQGKES QGHSNPPAFN FPAPESWANT TSSAPYQNIP CNGSSRTSQP RELIAPPKTV 1870 1880 1890 1900 1910 1920 KPPEDQLKPE SGEVSSSFNY SMLQHLGQFP PLMPNKQIAE SANCSSQQSP AGSKPAMSYA 1930 1940 1950 1960 SALRAPPKPR PPPEQAKKGS DPLSLLQELS LGSSPGSNGF YSYFK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H. DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Strain: C57BL/6 and Czech II. Tissue: Brain, Head and Mammary tumor.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 750-1964. Strain: C57BL/6J. Tissue: Testis.
[5]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1788, MASS SPECTROMETRY. Tissue: Liver.
[6]	"Cardiac deletion of Smyd2 is dispensable for mouse heart development." Diehl F., Brown M.A., van Amerongen M.J., Novoyatleva T., Wietelmann A., Harriss J., Ferrazzi F., Bottger T., Harvey R.P., Tucker P.W., Engel F.B. PLoS ONE 5:E9748-E9748(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SMYD2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB093209 mRNA. Translation: BAC41393.1. Different initiation. AL645947 Genomic DNA. Translation: CAM21447.1. BC021818 mRNA. Translation: AAH21818.1. BC076626 mRNA. Translation: AAH76626.1. BC130582 mRNA. Translation: AAI30583.1. AK033094 mRNA. Translation: BAC28150.1.
IPI	IPI00453654. IPI00649664. IPI00915056.
RefSeq	NP_938040.1. NM_198298.1.
UniGene	Mm.272047. Mm.394603. Mm.490425.
3D structure databases
ProteinModelPortal	Q6DFV5.
SMR	Q6DFV5. Positions 193-218, 642-1050.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q6DFV5. 1 interaction.
PTM databases
PhosphoSite	Q6DFV5.
Proteomic databases
PaxDb	Q6DFV5.
PRIDE	Q6DFV5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000075012; ENSMUSP00000074533; ENSMUSG00000020721. ENSMUST00000106746; ENSMUSP00000102357; ENSMUSG00000020721.
GeneID	78455.
KEGG	mmu:78455.
UCSC	uc007mav.1. mouse.
Organism-specific databases
CTD	9931.
MGI	MGI:1925705. Helz.
Rouge	Search...
Phylogenomic databases
eggNOG	COG1112.
GeneTree	ENSGT00550000074391.
HOGENOM	HOG000231202.
HOVERGEN	HBG031603.
InParanoid	Q8BZZ6.
Gene expression databases
ArrayExpress	Q6DFV5.
Bgee	Q6DFV5.
Genevestigator	Q6DFV5.
Family and domain databases
InterPro	IPR000571. Znf_CCCH. [Graphical view]
Pfam	PF00642. zf-CCCH. 1 hit. [Graphical view]
SMART	SM00356. ZnF_C3H1. 1 hit. [Graphical view]
PROSITE	PS50103. ZF_C3H1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	348914.
SOURCE	Search...

Entry information

Entry name

HELZ_MOUSE

Accession

Primary (citable) accession number: Q6DFV5
Secondary accession number(s): A1L4L4 , A2AAU4, Q8BZZ6, Q8CHI3, Q8VDI3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2008
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program