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Q6DFV5

- HELZ_MOUSE

UniProt

Q6DFV5 - HELZ_MOUSE

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Protein
Probable helicase with zinc finger domain
Gene
Helz, Kiaa0054
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri178 – 20629C3H1-type
Add
BLAST
Nucleotide bindingi668 – 6758ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. helicase activity Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable helicase with zinc finger domain (EC:3.6.4.-)
Gene namesi
Name:Helz
Synonyms:Kiaa0054
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1925705. Helz.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19641964Probable helicase with zinc finger domain
PRO_0000354096Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1636 – 16361Phosphoserine By similarity
Modified residuei1760 – 17601Phosphoserine By similarity
Modified residuei1788 – 17881Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6DFV5.
PaxDbiQ6DFV5.
PRIDEiQ6DFV5.

PTM databases

PhosphoSiteiQ6DFV5.

Expressioni

Gene expression databases

ArrayExpressiQ6DFV5.
BgeeiQ6DFV5.
GenevestigatoriQ6DFV5.

Interactioni

Subunit structurei

Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II By similarity. Interacts with SMYD2.1 Publication

Protein-protein interaction databases

BioGridi219414. 3 interactions.
IntActiQ6DFV5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6DFV5.
SMRiQ6DFV5. Positions 642-1050.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi794 – 7974DEAA box

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG1112.
GeneTreeiENSGT00550000074391.
HOGENOMiHOG000231202.
HOVERGENiHBG031603.
InParanoidiQ8BZZ6.
PhylomeDBiQ6DFV5.
TreeFamiTF323999.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6DFV5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEDRRAERSC EQACASLQRQ DYDMALQHCT DALLSLGQYS MADFTGPCPV     50
EVERIKIESL LYRIASFLQL KNYGQADEDC RHVLGEGLAK GERAFRAVLC 100
CMQLKGKLQL VSSILAKSLS GESLNGMVTK DLTRLKTLLT ETETATSNVL 150
SGCHVEDLDE GSCNGWHFRP PPRGITSSEE YTLCKRFLEQ GICRYGAQCT 200
SAHSQEELAE WQKRYASRLI KLKQQSENKQ LSGSYMETLI EKWMSSLSPE 250
KVLSECIEGV QVEHSPDLSV TVNTKKSHQT WTFALTCKPA RMLYRVALLY 300
DAHRPHFSII AISAGDSTTQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG 350
IAFNTEIFGT FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKRQLV 400
TTAKRWDSSS KTIVDFEPNE TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS 450
LTKTNYQARL HDLLYIEEIA QYKEVSRFNL KVQLQILASF MLTGVSGGAK 500
YAQNGQLFGR FKLTETLSED TLAGRLVMTR VNAVYLLPVP KEKLVQSQGT 550
KEKVYEATIE EKTKDYVFLR ISRECCEELS LRPDCDIQVE LQFQLNRLPL 600
CEMHYALDRI KDNAVLFPDI SMTPTIPWSP NRQWDEQLDP RLNAKQKEAV 650
LAITTPLSIQ LPPVLIIGPY GTGKTFTLAQ AAKHILQQQE TRILICTHSN 700
SAADLYIKDY LHPYVEAGNP QARPLRVYFR NRWVKTVHPV VHQYCLISST 750
QSTFQMPQKE DILKHRVVVV TLSTSQYLCQ LDLEPGFFTH VLLDEAAQAM 800
ECETIMPLAL ATKNTRIVLA GDHMQLSPFV YSEFARERNL HVSLLDRLYE 850
HYPAEFPCRI LLCENYRSHE AIINYTSELF YEGKLMASGK QPAHKDFYPL 900
TFFTARGEDV QEKNSTAFYN NAEVFEVVER VEELRRKWPV AWGKLDDGSI 950
GVVTPYADQV FRIRAELRKK RLSDVNVERV LNVQGKQFRV LFLSTVRTRH 1000
TCKHKQTPIK KKEQLLEDST EDLDYGFLSN YKLLNTAITR AQSLVAVVGD 1050
PVALCSIGRC RKFWERFIAL CHENHSLHGI TFEQIKAQLE ALELKKTYVL 1100
NPLAPEFIPR ALRLQHSGNS SRQQQSPPKV KSLYHPQSDH FQSDGIVQPN 1150
PSVLIGNPIR AYTPPPPLGP HPNLGKSPSP VQRIDPHTGT SILYVPAVYG 1200
GNVVMSVPLP VPWTGYQGRF AVDPRIITHQ AAMAYNMNLL HTHGRGSPIP 1250
YGLGHHPPVS LGQPQSQHAE KDQQEQNRNG KTDTNNPGPE INKIRTPEKK 1300
PTEPKQVDLE SNPQNRSPES RPGVVYSNTK FPRKDHLNPR HINNLPLPAP 1350
HAQYAIPSRH FHPLPQLPRP PFPASQPHTL LNQQQNNLPE QPNQMAPQPN 1400
QVAPQPNQMT PQPNQVAPQP NQVVQQQSQA PPQAPQPAPQ LSPAFQAGPT 1450
NAFFNNAVAH RPQSPAAEAV GPEQPPPPGL PDGHSPLRAI TQPGPILASP 1500
LNNFVDESSP GLPIEEALDG VHGSVALETL RQQQARLQQW SEHHAYLSQG 1550
GIPYSHHHHP HLPHLPHTPI GLHQPPVRAE WKVAGRADDE TETTFSRFQD 1600
LLRELSHRDQ GDTGELAEMP PPQSRLLQYR QVQPRSPPAV PSPPSSTDHS 1650
SQFANFNDSS RDIEVANSPA FPQRLPPQLF GSPFSLPSEH LAPPPLKYLA 1700
PEGAWNFANL QQNHLIGPGF PYGLPPLPPR PPQNPFIHIQ NHQHAAGQEP 1750
FHPLSSRTVS ASSLPSLEEY EPRGPGRPLY QRRISSSSAQ PCVEEASAPQ 1800
DSLAQGKESQ GHSNPPAFNF PAPESWANTT SSAPYQNIPC NGSSRTSQPR 1850
ELIAPPKTVK PPEDQLKPES GEVSSSFNYS MLQHLGQFPP LMPNKQIAES 1900
ANCSSQQSPA GSKPAMSYAS ALRAPPKPRP PPEQAKKGSD PLSLLQELSL 1950
GSSPGSNGFY SYFK 1964
Length:1,964
Mass (Da):219,880
Last modified:November 25, 2008 - v2
Checksum:iBED050BC57CFE065
GO
Isoform 2 (identifier: Q6DFV5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1598-1616: FQDLLRELSHRDQGDTGEL → YSSRPGPALITTCVWSA
     1617-1964: Missing.

Show »
Length:1,614
Mass (Da):181,841
Checksum:i6E5AF1AB37743D2E
GO
Isoform 3 (identifier: Q6DFV5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     690-690: E → ET

Show »
Length:1,965
Mass (Da):219,981
Checksum:i5AE327003458D904
GO

Sequence cautioni

The sequence BAC41393.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei690 – 6901E → ET in isoform 3.
VSP_035795
Alternative sequencei1598 – 161619FQDLL…DTGEL → YSSRPGPALITTCVWSA in isoform 2.
VSP_035796Add
BLAST
Alternative sequencei1617 – 1964348Missing in isoform 2.
VSP_035797Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti963 – 9631I → T in BAC28150. 1 Publication
Sequence conflicti1193 – 11931L → P in BAC28150. 1 Publication
Sequence conflicti1496 – 14961I → N in BAC28150. 1 Publication
Sequence conflicti1746 – 17461A → V in AAH21818. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093209 mRNA. Translation: BAC41393.1. Different initiation.
AL645947 Genomic DNA. Translation: CAM21447.1.
BC021818 mRNA. Translation: AAH21818.1.
BC076626 mRNA. Translation: AAH76626.1.
BC130582 mRNA. Translation: AAI30583.1.
AK033094 mRNA. Translation: BAC28150.1.
CCDSiCCDS25569.1. [Q6DFV5-3]
RefSeqiNP_938040.1. NM_198298.1.
XP_006534567.1. XM_006534504.1.
XP_006534568.1. XM_006534505.1.
XP_006534569.1. XM_006534506.1.
XP_006534570.1. XM_006534507.1. [Q6DFV5-1]
UniGeneiMm.272047.
Mm.394603.
Mm.490425.

Genome annotation databases

EnsembliENSMUST00000075012; ENSMUSP00000074533; ENSMUSG00000020721.
ENSMUST00000106746; ENSMUSP00000102357; ENSMUSG00000020721. [Q6DFV5-1]
GeneIDi78455.
KEGGimmu:78455.
UCSCiuc007mav.1. mouse. [Q6DFV5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB093209 mRNA. Translation: BAC41393.1 . Different initiation.
AL645947 Genomic DNA. Translation: CAM21447.1 .
BC021818 mRNA. Translation: AAH21818.1 .
BC076626 mRNA. Translation: AAH76626.1 .
BC130582 mRNA. Translation: AAI30583.1 .
AK033094 mRNA. Translation: BAC28150.1 .
CCDSi CCDS25569.1. [Q6DFV5-3 ]
RefSeqi NP_938040.1. NM_198298.1.
XP_006534567.1. XM_006534504.1.
XP_006534568.1. XM_006534505.1.
XP_006534569.1. XM_006534506.1.
XP_006534570.1. XM_006534507.1. [Q6DFV5-1 ]
UniGenei Mm.272047.
Mm.394603.
Mm.490425.

3D structure databases

ProteinModelPortali Q6DFV5.
SMRi Q6DFV5. Positions 642-1050.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 219414. 3 interactions.
IntActi Q6DFV5. 1 interaction.

PTM databases

PhosphoSitei Q6DFV5.

Proteomic databases

MaxQBi Q6DFV5.
PaxDbi Q6DFV5.
PRIDEi Q6DFV5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075012 ; ENSMUSP00000074533 ; ENSMUSG00000020721 .
ENSMUST00000106746 ; ENSMUSP00000102357 ; ENSMUSG00000020721 . [Q6DFV5-1 ]
GeneIDi 78455.
KEGGi mmu:78455.
UCSCi uc007mav.1. mouse. [Q6DFV5-3 ]

Organism-specific databases

CTDi 9931.
MGIi MGI:1925705. Helz.
Rougei Search...

Phylogenomic databases

eggNOGi COG1112.
GeneTreei ENSGT00550000074391.
HOGENOMi HOG000231202.
HOVERGENi HBG031603.
InParanoidi Q8BZZ6.
PhylomeDBi Q6DFV5.
TreeFami TF323999.

Miscellaneous databases

NextBioi 348914.
PROi Q6DFV5.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6DFV5.
Bgeei Q6DFV5.
Genevestigatori Q6DFV5.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR000571. Znf_CCCH.
[Graphical view ]
Pfami PF00642. zf-CCCH. 1 hit.
[Graphical view ]
SMARTi SM00356. ZnF_C3H1. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50103. ZF_C3H1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Strain: C57BL/6 and Czech II.
    Tissue: Brain, Head and Mammary tumor.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 750-1964.
    Strain: C57BL/6J.
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: INTERACTION WITH SMYD2.

Entry informationi

Entry nameiHELZ_MOUSE
AccessioniPrimary (citable) accession number: Q6DFV5
Secondary accession number(s): A1L4L4
, A2AAU4, Q8BZZ6, Q8CHI3, Q8VDI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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