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Q6DFV5

- HELZ_MOUSE

UniProt

Q6DFV5 - HELZ_MOUSE

Protein

Probable helicase with zinc finger domain

Gene

Helz

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri178 – 20629C3H1-typePROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi668 – 6758ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. helicase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: UniProtKB

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable helicase with zinc finger domain (EC:3.6.4.-)
    Gene namesi
    Name:Helz
    Synonyms:Kiaa0054
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1925705. Helz.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19641964Probable helicase with zinc finger domainPRO_0000354096Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1636 – 16361PhosphoserineBy similarity
    Modified residuei1760 – 17601PhosphoserineBy similarity
    Modified residuei1788 – 17881PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6DFV5.
    PaxDbiQ6DFV5.
    PRIDEiQ6DFV5.

    PTM databases

    PhosphoSiteiQ6DFV5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6DFV5.
    BgeeiQ6DFV5.
    GenevestigatoriQ6DFV5.

    Interactioni

    Subunit structurei

    Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II By similarity. Interacts with SMYD2.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi219414. 3 interactions.
    IntActiQ6DFV5. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DFV5.
    SMRiQ6DFV5. Positions 642-1050.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi794 – 7974DEAA box

    Sequence similaritiesi

    Belongs to the DNA2/NAM7 helicase family.Curated
    Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri178 – 20629C3H1-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1112.
    GeneTreeiENSGT00550000074391.
    HOGENOMiHOG000231202.
    HOVERGENiHBG031603.
    InParanoidiQ8BZZ6.
    PhylomeDBiQ6DFV5.
    TreeFamiTF323999.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    4.10.1000.10. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR000571. Znf_CCCH.
    [Graphical view]
    PfamiPF00642. zf-CCCH. 1 hit.
    [Graphical view]
    SMARTiSM00356. ZnF_C3H1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50103. ZF_C3H1. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6DFV5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEDRRAERSC EQACASLQRQ DYDMALQHCT DALLSLGQYS MADFTGPCPV     50
    EVERIKIESL LYRIASFLQL KNYGQADEDC RHVLGEGLAK GERAFRAVLC 100
    CMQLKGKLQL VSSILAKSLS GESLNGMVTK DLTRLKTLLT ETETATSNVL 150
    SGCHVEDLDE GSCNGWHFRP PPRGITSSEE YTLCKRFLEQ GICRYGAQCT 200
    SAHSQEELAE WQKRYASRLI KLKQQSENKQ LSGSYMETLI EKWMSSLSPE 250
    KVLSECIEGV QVEHSPDLSV TVNTKKSHQT WTFALTCKPA RMLYRVALLY 300
    DAHRPHFSII AISAGDSTTQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG 350
    IAFNTEIFGT FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKRQLV 400
    TTAKRWDSSS KTIVDFEPNE TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS 450
    LTKTNYQARL HDLLYIEEIA QYKEVSRFNL KVQLQILASF MLTGVSGGAK 500
    YAQNGQLFGR FKLTETLSED TLAGRLVMTR VNAVYLLPVP KEKLVQSQGT 550
    KEKVYEATIE EKTKDYVFLR ISRECCEELS LRPDCDIQVE LQFQLNRLPL 600
    CEMHYALDRI KDNAVLFPDI SMTPTIPWSP NRQWDEQLDP RLNAKQKEAV 650
    LAITTPLSIQ LPPVLIIGPY GTGKTFTLAQ AAKHILQQQE TRILICTHSN 700
    SAADLYIKDY LHPYVEAGNP QARPLRVYFR NRWVKTVHPV VHQYCLISST 750
    QSTFQMPQKE DILKHRVVVV TLSTSQYLCQ LDLEPGFFTH VLLDEAAQAM 800
    ECETIMPLAL ATKNTRIVLA GDHMQLSPFV YSEFARERNL HVSLLDRLYE 850
    HYPAEFPCRI LLCENYRSHE AIINYTSELF YEGKLMASGK QPAHKDFYPL 900
    TFFTARGEDV QEKNSTAFYN NAEVFEVVER VEELRRKWPV AWGKLDDGSI 950
    GVVTPYADQV FRIRAELRKK RLSDVNVERV LNVQGKQFRV LFLSTVRTRH 1000
    TCKHKQTPIK KKEQLLEDST EDLDYGFLSN YKLLNTAITR AQSLVAVVGD 1050
    PVALCSIGRC RKFWERFIAL CHENHSLHGI TFEQIKAQLE ALELKKTYVL 1100
    NPLAPEFIPR ALRLQHSGNS SRQQQSPPKV KSLYHPQSDH FQSDGIVQPN 1150
    PSVLIGNPIR AYTPPPPLGP HPNLGKSPSP VQRIDPHTGT SILYVPAVYG 1200
    GNVVMSVPLP VPWTGYQGRF AVDPRIITHQ AAMAYNMNLL HTHGRGSPIP 1250
    YGLGHHPPVS LGQPQSQHAE KDQQEQNRNG KTDTNNPGPE INKIRTPEKK 1300
    PTEPKQVDLE SNPQNRSPES RPGVVYSNTK FPRKDHLNPR HINNLPLPAP 1350
    HAQYAIPSRH FHPLPQLPRP PFPASQPHTL LNQQQNNLPE QPNQMAPQPN 1400
    QVAPQPNQMT PQPNQVAPQP NQVVQQQSQA PPQAPQPAPQ LSPAFQAGPT 1450
    NAFFNNAVAH RPQSPAAEAV GPEQPPPPGL PDGHSPLRAI TQPGPILASP 1500
    LNNFVDESSP GLPIEEALDG VHGSVALETL RQQQARLQQW SEHHAYLSQG 1550
    GIPYSHHHHP HLPHLPHTPI GLHQPPVRAE WKVAGRADDE TETTFSRFQD 1600
    LLRELSHRDQ GDTGELAEMP PPQSRLLQYR QVQPRSPPAV PSPPSSTDHS 1650
    SQFANFNDSS RDIEVANSPA FPQRLPPQLF GSPFSLPSEH LAPPPLKYLA 1700
    PEGAWNFANL QQNHLIGPGF PYGLPPLPPR PPQNPFIHIQ NHQHAAGQEP 1750
    FHPLSSRTVS ASSLPSLEEY EPRGPGRPLY QRRISSSSAQ PCVEEASAPQ 1800
    DSLAQGKESQ GHSNPPAFNF PAPESWANTT SSAPYQNIPC NGSSRTSQPR 1850
    ELIAPPKTVK PPEDQLKPES GEVSSSFNYS MLQHLGQFPP LMPNKQIAES 1900
    ANCSSQQSPA GSKPAMSYAS ALRAPPKPRP PPEQAKKGSD PLSLLQELSL 1950
    GSSPGSNGFY SYFK 1964
    Length:1,964
    Mass (Da):219,880
    Last modified:November 25, 2008 - v2
    Checksum:iBED050BC57CFE065
    GO
    Isoform 2 (identifier: Q6DFV5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1598-1616: FQDLLRELSHRDQGDTGEL → YSSRPGPALITTCVWSA
         1617-1964: Missing.

    Show »
    Length:1,614
    Mass (Da):181,841
    Checksum:i6E5AF1AB37743D2E
    GO
    Isoform 3 (identifier: Q6DFV5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         690-690: E → ET

    Show »
    Length:1,965
    Mass (Da):219,981
    Checksum:i5AE327003458D904
    GO

    Sequence cautioni

    The sequence BAC41393.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti963 – 9631I → T in BAC28150. (PubMed:16141072)Curated
    Sequence conflicti1193 – 11931L → P in BAC28150. (PubMed:16141072)Curated
    Sequence conflicti1496 – 14961I → N in BAC28150. (PubMed:16141072)Curated
    Sequence conflicti1746 – 17461A → V in AAH21818. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei690 – 6901E → ET in isoform 3. 1 PublicationVSP_035795
    Alternative sequencei1598 – 161619FQDLL…DTGEL → YSSRPGPALITTCVWSA in isoform 2. 1 PublicationVSP_035796Add
    BLAST
    Alternative sequencei1617 – 1964348Missing in isoform 2. 1 PublicationVSP_035797Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB093209 mRNA. Translation: BAC41393.1. Different initiation.
    AL645947 Genomic DNA. Translation: CAM21447.1.
    BC021818 mRNA. Translation: AAH21818.1.
    BC076626 mRNA. Translation: AAH76626.1.
    BC130582 mRNA. Translation: AAI30583.1.
    AK033094 mRNA. Translation: BAC28150.1.
    CCDSiCCDS25569.1. [Q6DFV5-3]
    RefSeqiNP_938040.1. NM_198298.1.
    XP_006534567.1. XM_006534504.1.
    XP_006534568.1. XM_006534505.1.
    XP_006534569.1. XM_006534506.1.
    XP_006534570.1. XM_006534507.1. [Q6DFV5-1]
    UniGeneiMm.272047.
    Mm.394603.
    Mm.490425.

    Genome annotation databases

    EnsembliENSMUST00000075012; ENSMUSP00000074533; ENSMUSG00000020721.
    ENSMUST00000106746; ENSMUSP00000102357; ENSMUSG00000020721. [Q6DFV5-1]
    GeneIDi78455.
    KEGGimmu:78455.
    UCSCiuc007mav.1. mouse. [Q6DFV5-3]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB093209 mRNA. Translation: BAC41393.1 . Different initiation.
    AL645947 Genomic DNA. Translation: CAM21447.1 .
    BC021818 mRNA. Translation: AAH21818.1 .
    BC076626 mRNA. Translation: AAH76626.1 .
    BC130582 mRNA. Translation: AAI30583.1 .
    AK033094 mRNA. Translation: BAC28150.1 .
    CCDSi CCDS25569.1. [Q6DFV5-3 ]
    RefSeqi NP_938040.1. NM_198298.1.
    XP_006534567.1. XM_006534504.1.
    XP_006534568.1. XM_006534505.1.
    XP_006534569.1. XM_006534506.1.
    XP_006534570.1. XM_006534507.1. [Q6DFV5-1 ]
    UniGenei Mm.272047.
    Mm.394603.
    Mm.490425.

    3D structure databases

    ProteinModelPortali Q6DFV5.
    SMRi Q6DFV5. Positions 642-1050.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 219414. 3 interactions.
    IntActi Q6DFV5. 1 interaction.

    PTM databases

    PhosphoSitei Q6DFV5.

    Proteomic databases

    MaxQBi Q6DFV5.
    PaxDbi Q6DFV5.
    PRIDEi Q6DFV5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075012 ; ENSMUSP00000074533 ; ENSMUSG00000020721 .
    ENSMUST00000106746 ; ENSMUSP00000102357 ; ENSMUSG00000020721 . [Q6DFV5-1 ]
    GeneIDi 78455.
    KEGGi mmu:78455.
    UCSCi uc007mav.1. mouse. [Q6DFV5-3 ]

    Organism-specific databases

    CTDi 9931.
    MGIi MGI:1925705. Helz.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG1112.
    GeneTreei ENSGT00550000074391.
    HOGENOMi HOG000231202.
    HOVERGENi HBG031603.
    InParanoidi Q8BZZ6.
    PhylomeDBi Q6DFV5.
    TreeFami TF323999.

    Miscellaneous databases

    NextBioi 348914.
    PROi Q6DFV5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6DFV5.
    Bgeei Q6DFV5.
    Genevestigatori Q6DFV5.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    4.10.1000.10. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR000571. Znf_CCCH.
    [Graphical view ]
    Pfami PF00642. zf-CCCH. 1 hit.
    [Graphical view ]
    SMARTi SM00356. ZnF_C3H1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50103. ZF_C3H1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
      DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Strain: C57BL/6 and Czech II.
      Tissue: Brain, Head and Mammary tumor.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 750-1964.
      Strain: C57BL/6J.
      Tissue: Testis.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. Cited for: INTERACTION WITH SMYD2.

    Entry informationi

    Entry nameiHELZ_MOUSE
    AccessioniPrimary (citable) accession number: Q6DFV5
    Secondary accession number(s): A1L4L4
    , A2AAU4, Q8BZZ6, Q8CHI3, Q8VDI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3