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Q6DFV5 (HELZ_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable helicase with zinc finger domain

EC=3.6.4.-
Gene names
Name:Helz
Synonyms:Kiaa0054
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1964 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo By similarity.

Subunit structure

Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II By similarity. Interacts with SMYD2. Ref.6

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the DNA2/NAM7 helicase family.

Contains 1 C3H1-type zinc finger.

Sequence caution

The sequence BAC41393.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainZinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionHelicase
Hydrolase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

helicase activity

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction Ref.6. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6DFV5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6DFV5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1598-1616: FQDLLRELSHRDQGDTGEL → YSSRPGPALITTCVWSA
     1617-1964: Missing.
Isoform 3 (identifier: Q6DFV5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     690-690: E → ET

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19641964Probable helicase with zinc finger domain
PRO_0000354096

Regions

Zinc finger178 – 20629C3H1-type
Nucleotide binding668 – 6758ATP Potential
Motif794 – 7974DEAA box

Amino acid modifications

Modified residue16361Phosphoserine By similarity
Modified residue17601Phosphoserine By similarity
Modified residue17881Phosphoserine By similarity

Natural variations

Alternative sequence6901E → ET in isoform 3.
VSP_035795
Alternative sequence1598 – 161619FQDLL…DTGEL → YSSRPGPALITTCVWSA in isoform 2.
VSP_035796
Alternative sequence1617 – 1964348Missing in isoform 2.
VSP_035797

Experimental info

Sequence conflict9631I → T in BAC28150. Ref.4
Sequence conflict11931L → P in BAC28150. Ref.4
Sequence conflict14961I → N in BAC28150. Ref.4
Sequence conflict17461A → V in AAH21818. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: BED050BC57CFE065

FASTA1,964219,880
        10         20         30         40         50         60 
MEDRRAERSC EQACASLQRQ DYDMALQHCT DALLSLGQYS MADFTGPCPV EVERIKIESL 

        70         80         90        100        110        120 
LYRIASFLQL KNYGQADEDC RHVLGEGLAK GERAFRAVLC CMQLKGKLQL VSSILAKSLS 

       130        140        150        160        170        180 
GESLNGMVTK DLTRLKTLLT ETETATSNVL SGCHVEDLDE GSCNGWHFRP PPRGITSSEE 

       190        200        210        220        230        240 
YTLCKRFLEQ GICRYGAQCT SAHSQEELAE WQKRYASRLI KLKQQSENKQ LSGSYMETLI 

       250        260        270        280        290        300 
EKWMSSLSPE KVLSECIEGV QVEHSPDLSV TVNTKKSHQT WTFALTCKPA RMLYRVALLY 

       310        320        330        340        350        360 
DAHRPHFSII AISAGDSTTQ VSQEVPENCQ EWIGGKMAQN GLDHYVYKVG IAFNTEIFGT 

       370        380        390        400        410        420 
FRQTIVFDFG LEPVLMQRVM IDAASTEDLE YLMHAKRQLV TTAKRWDSSS KTIVDFEPNE 

       430        440        450        460        470        480 
TTDLEKSLLI RYQIPLSADQ LFTQSVLDKS LTKTNYQARL HDLLYIEEIA QYKEVSRFNL 

       490        500        510        520        530        540 
KVQLQILASF MLTGVSGGAK YAQNGQLFGR FKLTETLSED TLAGRLVMTR VNAVYLLPVP 

       550        560        570        580        590        600 
KEKLVQSQGT KEKVYEATIE EKTKDYVFLR ISRECCEELS LRPDCDIQVE LQFQLNRLPL 

       610        620        630        640        650        660 
CEMHYALDRI KDNAVLFPDI SMTPTIPWSP NRQWDEQLDP RLNAKQKEAV LAITTPLSIQ 

       670        680        690        700        710        720 
LPPVLIIGPY GTGKTFTLAQ AAKHILQQQE TRILICTHSN SAADLYIKDY LHPYVEAGNP 

       730        740        750        760        770        780 
QARPLRVYFR NRWVKTVHPV VHQYCLISST QSTFQMPQKE DILKHRVVVV TLSTSQYLCQ 

       790        800        810        820        830        840 
LDLEPGFFTH VLLDEAAQAM ECETIMPLAL ATKNTRIVLA GDHMQLSPFV YSEFARERNL 

       850        860        870        880        890        900 
HVSLLDRLYE HYPAEFPCRI LLCENYRSHE AIINYTSELF YEGKLMASGK QPAHKDFYPL 

       910        920        930        940        950        960 
TFFTARGEDV QEKNSTAFYN NAEVFEVVER VEELRRKWPV AWGKLDDGSI GVVTPYADQV 

       970        980        990       1000       1010       1020 
FRIRAELRKK RLSDVNVERV LNVQGKQFRV LFLSTVRTRH TCKHKQTPIK KKEQLLEDST 

      1030       1040       1050       1060       1070       1080 
EDLDYGFLSN YKLLNTAITR AQSLVAVVGD PVALCSIGRC RKFWERFIAL CHENHSLHGI 

      1090       1100       1110       1120       1130       1140 
TFEQIKAQLE ALELKKTYVL NPLAPEFIPR ALRLQHSGNS SRQQQSPPKV KSLYHPQSDH 

      1150       1160       1170       1180       1190       1200 
FQSDGIVQPN PSVLIGNPIR AYTPPPPLGP HPNLGKSPSP VQRIDPHTGT SILYVPAVYG 

      1210       1220       1230       1240       1250       1260 
GNVVMSVPLP VPWTGYQGRF AVDPRIITHQ AAMAYNMNLL HTHGRGSPIP YGLGHHPPVS 

      1270       1280       1290       1300       1310       1320 
LGQPQSQHAE KDQQEQNRNG KTDTNNPGPE INKIRTPEKK PTEPKQVDLE SNPQNRSPES 

      1330       1340       1350       1360       1370       1380 
RPGVVYSNTK FPRKDHLNPR HINNLPLPAP HAQYAIPSRH FHPLPQLPRP PFPASQPHTL 

      1390       1400       1410       1420       1430       1440 
LNQQQNNLPE QPNQMAPQPN QVAPQPNQMT PQPNQVAPQP NQVVQQQSQA PPQAPQPAPQ 

      1450       1460       1470       1480       1490       1500 
LSPAFQAGPT NAFFNNAVAH RPQSPAAEAV GPEQPPPPGL PDGHSPLRAI TQPGPILASP 

      1510       1520       1530       1540       1550       1560 
LNNFVDESSP GLPIEEALDG VHGSVALETL RQQQARLQQW SEHHAYLSQG GIPYSHHHHP 

      1570       1580       1590       1600       1610       1620 
HLPHLPHTPI GLHQPPVRAE WKVAGRADDE TETTFSRFQD LLRELSHRDQ GDTGELAEMP 

      1630       1640       1650       1660       1670       1680 
PPQSRLLQYR QVQPRSPPAV PSPPSSTDHS SQFANFNDSS RDIEVANSPA FPQRLPPQLF 

      1690       1700       1710       1720       1730       1740 
GSPFSLPSEH LAPPPLKYLA PEGAWNFANL QQNHLIGPGF PYGLPPLPPR PPQNPFIHIQ 

      1750       1760       1770       1780       1790       1800 
NHQHAAGQEP FHPLSSRTVS ASSLPSLEEY EPRGPGRPLY QRRISSSSAQ PCVEEASAPQ 

      1810       1820       1830       1840       1850       1860 
DSLAQGKESQ GHSNPPAFNF PAPESWANTT SSAPYQNIPC NGSSRTSQPR ELIAPPKTVK 

      1870       1880       1890       1900       1910       1920 
PPEDQLKPES GEVSSSFNYS MLQHLGQFPP LMPNKQIAES ANCSSQQSPA GSKPAMSYAS 

      1930       1940       1950       1960 
ALRAPPKPRP PPEQAKKGSD PLSLLQELSL GSSPGSNGFY SYFK 

« Hide

Isoform 2 [UniParc].

Checksum: 6E5AF1AB37743D2E
Show »

FASTA1,614181,841
Isoform 3 [UniParc].

Checksum: 5AE327003458D904
Show »

FASTA1,965219,981

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Strain: C57BL/6 and Czech II.
Tissue: Brain, Head and Mammary tumor.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 750-1964.
Strain: C57BL/6J.
Tissue: Testis.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"Cardiac deletion of Smyd2 is dispensable for mouse heart development."
Diehl F., Brown M.A., van Amerongen M.J., Novoyatleva T., Wietelmann A., Harriss J., Ferrazzi F., Bottger T., Harvey R.P., Tucker P.W., Engel F.B.
PLoS ONE 5:E9748-E9748(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SMYD2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB093209 mRNA. Translation: BAC41393.1. Different initiation.
AL645947 Genomic DNA. Translation: CAM21447.1.
BC021818 mRNA. Translation: AAH21818.1.
BC076626 mRNA. Translation: AAH76626.1.
BC130582 mRNA. Translation: AAI30583.1.
AK033094 mRNA. Translation: BAC28150.1.
CCDSCCDS25569.1. [Q6DFV5-3]
RefSeqNP_938040.1. NM_198298.1.
XP_006534567.1. XM_006534504.1.
XP_006534568.1. XM_006534505.1.
XP_006534569.1. XM_006534506.1.
XP_006534570.1. XM_006534507.1. [Q6DFV5-1]
UniGeneMm.272047.
Mm.394603.
Mm.490425.

3D structure databases

ProteinModelPortalQ6DFV5.
SMRQ6DFV5. Positions 642-1050.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid219414. 3 interactions.
IntActQ6DFV5. 1 interaction.

PTM databases

PhosphoSiteQ6DFV5.

Proteomic databases

MaxQBQ6DFV5.
PaxDbQ6DFV5.
PRIDEQ6DFV5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000075012; ENSMUSP00000074533; ENSMUSG00000020721.
ENSMUST00000106746; ENSMUSP00000102357; ENSMUSG00000020721. [Q6DFV5-1]
GeneID78455.
KEGGmmu:78455.
UCSCuc007mav.1. mouse. [Q6DFV5-3]

Organism-specific databases

CTD9931.
MGIMGI:1925705. Helz.
RougeSearch...

Phylogenomic databases

eggNOGCOG1112.
GeneTreeENSGT00550000074391.
HOGENOMHOG000231202.
HOVERGENHBG031603.
InParanoidQ8BZZ6.
PhylomeDBQ6DFV5.
TreeFamTF323999.

Gene expression databases

ArrayExpressQ6DFV5.
BgeeQ6DFV5.
GenevestigatorQ6DFV5.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
4.10.1000.10. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR000571. Znf_CCCH.
[Graphical view]
PfamPF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTSM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio348914.
PROQ6DFV5.
SOURCESearch...

Entry information

Entry nameHELZ_MOUSE
AccessionPrimary (citable) accession number: Q6DFV5
Secondary accession number(s): A1L4L4 expand/collapse secondary AC list , A2AAU4, Q8BZZ6, Q8CHI3, Q8VDI3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot