Condensin-2 complex subunit G2 - Mus musculus (Mouse)

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Q6DFV1 (CNDG2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Condensin-2 complex subunit G2

Alternative name(s):
Chromosome-associated protein G2
Short name=CAP-G2
Leucine zipper protein 5
More than blood protein
Non-SMC condensin II complex subunit G2

Gene names

Name:	Ncapg2
Synonyms:	Luzp5, Mtb

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1138 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst. Ref.3
Subunit structure	Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in spleen, lung and testis as well as in hematopoietic cell lines. Ref.3
Developmental stage	Expressed form E7 when yolk sac hematopoiesis is initiated. Between E12.5 and E15.5 restricted to the developing fetal liver and the site of definitive hematopoiesis. Detected in thymus at E15.5 as well as the midbrain, forebrain and the olfactory epithelium. Ref.3
Sequence similarities	Contains 1 HEAT repeat.
Sequence caution	The sequence AAH08539.1 differs from that shown. Reason: Frameshift at position 916.

Ontologies

Keywords
Biological process	Cell cycle Cell division DNA condensation Mitosis
Cellular component	Nucleus
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW chromosome condensation Inferred from electronic annotation. Source: UniProtKB-KW inner cell mass cell proliferation Inferred from mutant phenotype Ref.3. Source: MGI mitosis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1138

1138

Condensin-2 complex subunit G2

PRO_0000255943

Regions

Repeat

459 – 497

HEAT

Amino acid modifications

Modified residue

Phosphoserine By similarity

Modified residue

1114

Phosphothreonine By similarity

Experimental info

Sequence conflict

589

S → P in AAR21588. Ref.3

Sequence conflict

674

L → F in AAH76631. Ref.2

Sequence conflict

723

D → G in AAR21588. Ref.3

Sequence conflict

758

Y → C in AAR21588. Ref.3

Sequence conflict

1101

T → A in AAR21588. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

Q6DFV1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: B893DD92853AB1B5
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FASTA

1,138

130,894

        10         20         30         40         50         60 
MEKREAFIQA VSKELVEEFL QFLQLDKDSS NPFSLSELLD ELSRKQKEEL WQRLKDLLTE 

        70         80         90        100        110        120 
TLLESPVDRW QTVEVEGADD MESEHSPKMR KSIKIICAIV TVILASVSII NEHENYGALL 

       130        140        150        160        170        180 
ECAVILNGIL YALPESEQKL QNSIQDLCVK WWERGLPAKE DMGKTAFIML LRRSLETKSG 

       190        200        210        220        230        240 
ADVCRLWRIH QALYCFDYDW EESREIKDML LECFINVNYI KKEEGRRFLS FLFSWNVDFI 

       250        260        270        280        290        300 
KMIHETIKNQ LAGLQKSLMV HIAEIYFRAW KKASGKMLET IEYDCIQDFM FHGIHLLRRS 

       310        320        330        340        350        360 
PVHSKVREVL SYFHQQKVRQ GVEEMLYRLY KPILWRGLKA RNSEVRSNAA LLFVEAFPIR 

       370        380        390        400        410        420 
DPNFTATEMD NEIQKQFEEL YNLIEDPYPR VRSTGILGVC KISSKYWEMM PPNILVDFLK 

       430        440        450        460        470        480 
KVTGELAFDI SSADVRCSVF KCLPIILDNK LSHPLLEQLL PTLRYSLHDN SEKVRVAFVD 

       490        500        510        520        530        540 
LLLKIKAVRA AKFWKICPME DILVRLEMDS RPVSRRLVSL IFNSFLPVNQ PEEVWCERCV 

       550        560        570        580        590        600 
TLIQMNRAAA RRFYQYAHEH TASTNIAKLI HVIRHCLNAC IQRTLREGSE AHKECEKENA 

       610        620        630        640        650        660 
SVLDKTLSVN DTASMAGLLE IIVILWKNIH RSLENNKEAK IYTINKFAAV LPEYLKVFKD 

       670        680        690        700        710        720 
ERCKIPLFML MSFLPASAVP VFSCGVISVL RNQESVTGRS YCTLLDCLCS WGQVGHVLEL 

       730        740        750        760        770        780 
IVDWLPTVPP QAKSNLASKR KVEINDTCSV KPELALLYME YLLTHPKNRE CLLSVPQKKL 

       790        800        810        820        830        840 
NQLLKALEGS KAELESFLQS PSGNPLNFNK ATALHAFGLY CRMSVHLQYK FCSEEKIHLS 

       850        860        870        880        890        900 
ILDDTGSWLE NKVLPLLEDQ EEEYLKLRKD VYQQIIQTYL AVCKDVVMVG LGDPKFQMQL 

       910        920        930        940        950        960 
LQRSFGIMKT VKGFFYVSLL LGILKEIAGN TIIHKTDSDE KVTVLFDLVQ EVFQKMLECI 

       970        980        990       1000       1010       1020 
ACIFRKQPEE SLPLFHSVQT PLHEFITTIQ SWHKDTAVHH AVLSTLIAAP VVEISHQLQK 

      1030       1040       1050       1060       1070       1080 
VSDIEELTSP QCLHDLPPFS RCLVGVIMKS SDVVRSFVDE LKACVTSGDV EGIVCLTAVL 

      1090       1100       1110       1120       1130 
HIILVINKGK HISAKVKEVA TAVYRKLKTF MEITLEEDSL ERFLYESSMR TLGEFLNP

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6 and Czech II. Tissue: Head and Mammary gland.
[3]	"More than blood, a novel gene required for mammalian postimplantation development." Smith E.D., Xu Y., Tomson B.N., Leung C.G., Fujiwara Y., Orkin S.H., Crispino J.D. Mol. Cell. Biol. 24:1168-1173(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-1138, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: 129/Sv.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC160634 Genomic DNA. No translation available. CT030173 Genomic DNA. No translation available. BC008539 mRNA. Translation: AAH08539.1. Sequence problems. BC076631 mRNA. Translation: AAH76631.1. AY455829 mRNA. Translation: AAR21588.1.
IPI	IPI00122854.
RefSeq	NP_598523.3. NM_133762.3.
UniGene	Mm.21516.
3D structure databases
ProteinModelPortal	Q6DFV1.
ModBase	Search...
PTM databases
PhosphoSite	Q6DFV1.
Proteomic databases
PaxDb	Q6DFV1.
PRIDE	Q6DFV1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000084828; ENSMUSP00000081889; ENSMUSG00000042029.
GeneID	76044.
KEGG	mmu:76044.
UCSC	uc007pht.1. mouse.
Organism-specific databases
CTD	54892.
MGI	MGI:1923294. Ncapg2.
Phylogenomic databases
eggNOG	NOG261934.
GeneTree	ENSGT00490000043432.
HOGENOM	HOG000111841.
HOVERGEN	HBG074124.
InParanoid	Q6DFV1.
KO	K11492.
OMA	FPIRDPN.
OrthoDB	EOG4SQWW1.
Gene expression databases
ArrayExpress	Q6DFV1.
Bgee	Q6DFV1.
CleanEx	MM_NCAPG2.
Genevestigator	Q6DFV1.
GermOnline	ENSMUSG00000042029. Mus musculus.
Family and domain databases
Gene3D	1.25.10.10. 4 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR024741. Condensin2_G2. [Graphical view]
Pfam	PF12422. Condensin2nSMC. 2 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	344499.
SOURCE	Search...

Entry information

Entry name

CNDG2_MOUSE

Accession

Primary (citable) accession number: Q6DFV1
Secondary accession number(s): E9QP71, Q6SLL0, Q922D1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents