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Q6DFV1

- CNDG2_MOUSE

UniProt

Q6DFV1 - CNDG2_MOUSE

Protein

Condensin-2 complex subunit G2

Gene

Ncapg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst.1 Publication

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. chromosome condensation Source: UniProtKB-KW
    2. inner cell mass cell proliferation Source: MGI
    3. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, DNA condensation, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_196580. Condensation of Prophase Chromosomes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Condensin-2 complex subunit G2
    Alternative name(s):
    Chromosome-associated protein G2
    Short name:
    CAP-G2
    Leucine zipper protein 5
    More than blood protein
    Non-SMC condensin II complex subunit G2
    Gene namesi
    Name:Ncapg2
    Synonyms:Luzp5, Mtb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1923294. Ncapg2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11381138Condensin-2 complex subunit G2PRO_0000255943Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei30 – 301PhosphoserineBy similarity
    Modified residuei1114 – 11141PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6DFV1.
    PaxDbiQ6DFV1.
    PRIDEiQ6DFV1.

    PTM databases

    PhosphoSiteiQ6DFV1.

    Expressioni

    Tissue specificityi

    Expressed in spleen, lung and testis as well as in hematopoietic cell lines.1 Publication

    Developmental stagei

    Expressed form E7 when yolk sac hematopoiesis is initiated. Between E12.5 and E15.5 restricted to the developing fetal liver and the site of definitive hematopoiesis. Detected in thymus at E15.5 as well as the midbrain, forebrain and the olfactory epithelium.1 Publication

    Gene expression databases

    ArrayExpressiQ6DFV1.
    BgeeiQ6DFV1.
    CleanExiMM_NCAPG2.
    GenevestigatoriQ6DFV1.

    Interactioni

    Subunit structurei

    Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.

    Protein-protein interaction databases

    BioGridi217926. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DFV1.
    SMRiQ6DFV1. Positions 455-482.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati459 – 49739HEATAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HEAT repeat.Curated

    Phylogenomic databases

    eggNOGiNOG261934.
    GeneTreeiENSGT00490000043432.
    HOGENOMiHOG000111841.
    HOVERGENiHBG074124.
    InParanoidiQ6DFV1.
    KOiK11492.
    OMAiTSKYWEM.
    OrthoDBiEOG73V6N3.
    TreeFamiTF101163.

    Family and domain databases

    Gene3Di1.25.10.10. 4 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR024741. Condensin2_G2.
    [Graphical view]
    PfamiPF12422. Condensin2nSMC. 2 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 4 hits.

    Sequencei

    Sequence statusi: Complete.

    Q6DFV1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKREAFIQA VSKELVEEFL QFLQLDKDSS NPFSLSELLD ELSRKQKEEL     50
    WQRLKDLLTE TLLESPVDRW QTVEVEGADD MESEHSPKMR KSIKIICAIV 100
    TVILASVSII NEHENYGALL ECAVILNGIL YALPESEQKL QNSIQDLCVK 150
    WWERGLPAKE DMGKTAFIML LRRSLETKSG ADVCRLWRIH QALYCFDYDW 200
    EESREIKDML LECFINVNYI KKEEGRRFLS FLFSWNVDFI KMIHETIKNQ 250
    LAGLQKSLMV HIAEIYFRAW KKASGKMLET IEYDCIQDFM FHGIHLLRRS 300
    PVHSKVREVL SYFHQQKVRQ GVEEMLYRLY KPILWRGLKA RNSEVRSNAA 350
    LLFVEAFPIR DPNFTATEMD NEIQKQFEEL YNLIEDPYPR VRSTGILGVC 400
    KISSKYWEMM PPNILVDFLK KVTGELAFDI SSADVRCSVF KCLPIILDNK 450
    LSHPLLEQLL PTLRYSLHDN SEKVRVAFVD LLLKIKAVRA AKFWKICPME 500
    DILVRLEMDS RPVSRRLVSL IFNSFLPVNQ PEEVWCERCV TLIQMNRAAA 550
    RRFYQYAHEH TASTNIAKLI HVIRHCLNAC IQRTLREGSE AHKECEKENA 600
    SVLDKTLSVN DTASMAGLLE IIVILWKNIH RSLENNKEAK IYTINKFAAV 650
    LPEYLKVFKD ERCKIPLFML MSFLPASAVP VFSCGVISVL RNQESVTGRS 700
    YCTLLDCLCS WGQVGHVLEL IVDWLPTVPP QAKSNLASKR KVEINDTCSV 750
    KPELALLYME YLLTHPKNRE CLLSVPQKKL NQLLKALEGS KAELESFLQS 800
    PSGNPLNFNK ATALHAFGLY CRMSVHLQYK FCSEEKIHLS ILDDTGSWLE 850
    NKVLPLLEDQ EEEYLKLRKD VYQQIIQTYL AVCKDVVMVG LGDPKFQMQL 900
    LQRSFGIMKT VKGFFYVSLL LGILKEIAGN TIIHKTDSDE KVTVLFDLVQ 950
    EVFQKMLECI ACIFRKQPEE SLPLFHSVQT PLHEFITTIQ SWHKDTAVHH 1000
    AVLSTLIAAP VVEISHQLQK VSDIEELTSP QCLHDLPPFS RCLVGVIMKS 1050
    SDVVRSFVDE LKACVTSGDV EGIVCLTAVL HIILVINKGK HISAKVKEVA 1100
    TAVYRKLKTF MEITLEEDSL ERFLYESSMR TLGEFLNP 1138
    Length:1,138
    Mass (Da):130,894
    Last modified:July 27, 2011 - v2
    Checksum:iB893DD92853AB1B5
    GO

    Sequence cautioni

    The sequence AAH08539.1 differs from that shown. Reason: Frameshift at position 916.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti589 – 5891S → P in AAR21588. (PubMed:14729962)Curated
    Sequence conflicti674 – 6741L → F in AAH76631. (PubMed:15489334)Curated
    Sequence conflicti723 – 7231D → G in AAR21588. (PubMed:14729962)Curated
    Sequence conflicti758 – 7581Y → C in AAR21588. (PubMed:14729962)Curated
    Sequence conflicti1101 – 11011T → A in AAR21588. (PubMed:14729962)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC160634 Genomic DNA. No translation available.
    CT030173 Genomic DNA. No translation available.
    BC008539 mRNA. Translation: AAH08539.1. Sequence problems.
    BC076631 mRNA. Translation: AAH76631.1.
    AY455829 mRNA. Translation: AAR21588.1.
    CCDSiCCDS26212.1.
    RefSeqiNP_598523.3. NM_133762.3.
    XP_006516412.1. XM_006516349.1.
    XP_006516413.1. XM_006516350.1.
    XP_006516414.1. XM_006516351.1.
    XP_006516415.1. XM_006516352.1.
    XP_006516416.1. XM_006516353.1.
    XP_006516417.1. XM_006516354.1.
    UniGeneiMm.491196.

    Genome annotation databases

    EnsembliENSMUST00000084828; ENSMUSP00000081889; ENSMUSG00000042029.
    GeneIDi76044.
    KEGGimmu:76044.
    UCSCiuc007pht.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC160634 Genomic DNA. No translation available.
    CT030173 Genomic DNA. No translation available.
    BC008539 mRNA. Translation: AAH08539.1 . Sequence problems.
    BC076631 mRNA. Translation: AAH76631.1 .
    AY455829 mRNA. Translation: AAR21588.1 .
    CCDSi CCDS26212.1.
    RefSeqi NP_598523.3. NM_133762.3.
    XP_006516412.1. XM_006516349.1.
    XP_006516413.1. XM_006516350.1.
    XP_006516414.1. XM_006516351.1.
    XP_006516415.1. XM_006516352.1.
    XP_006516416.1. XM_006516353.1.
    XP_006516417.1. XM_006516354.1.
    UniGenei Mm.491196.

    3D structure databases

    ProteinModelPortali Q6DFV1.
    SMRi Q6DFV1. Positions 455-482.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 217926. 1 interaction.

    PTM databases

    PhosphoSitei Q6DFV1.

    Proteomic databases

    MaxQBi Q6DFV1.
    PaxDbi Q6DFV1.
    PRIDEi Q6DFV1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084828 ; ENSMUSP00000081889 ; ENSMUSG00000042029 .
    GeneIDi 76044.
    KEGGi mmu:76044.
    UCSCi uc007pht.1. mouse.

    Organism-specific databases

    CTDi 54892.
    MGIi MGI:1923294. Ncapg2.

    Phylogenomic databases

    eggNOGi NOG261934.
    GeneTreei ENSGT00490000043432.
    HOGENOMi HOG000111841.
    HOVERGENi HBG074124.
    InParanoidi Q6DFV1.
    KOi K11492.
    OMAi TSKYWEM.
    OrthoDBi EOG73V6N3.
    TreeFami TF101163.

    Enzyme and pathway databases

    Reactomei REACT_196580. Condensation of Prophase Chromosomes.

    Miscellaneous databases

    NextBioi 344499.
    PROi Q6DFV1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6DFV1.
    Bgeei Q6DFV1.
    CleanExi MM_NCAPG2.
    Genevestigatori Q6DFV1.

    Family and domain databases

    Gene3Di 1.25.10.10. 4 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR024741. Condensin2_G2.
    [Graphical view ]
    Pfami PF12422. Condensin2nSMC. 2 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 4 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and Czech II.
      Tissue: Head and Mammary gland.
    3. "More than blood, a novel gene required for mammalian postimplantation development."
      Smith E.D., Xu Y., Tomson B.N., Leung C.G., Fujiwara Y., Orkin S.H., Crispino J.D.
      Mol. Cell. Biol. 24:1168-1173(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-1138, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
      Strain: 129/Sv.

    Entry informationi

    Entry nameiCNDG2_MOUSE
    AccessioniPrimary (citable) accession number: Q6DFV1
    Secondary accession number(s): E9QP71, Q6SLL0, Q922D1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3