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Q6DFV1

- CNDG2_MOUSE

UniProt

Q6DFV1 - CNDG2_MOUSE

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Protein

Condensin-2 complex subunit G2

Gene

Ncapg2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst.1 Publication

GO - Biological processi

  1. chromosome condensation Source: UniProtKB-KW
  2. inner cell mass cell proliferation Source: MGI
  3. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiREACT_196580. Condensation of Prophase Chromosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin-2 complex subunit G2
Alternative name(s):
Chromosome-associated protein G2
Short name:
CAP-G2
Leucine zipper protein 5
More than blood protein
Non-SMC condensin II complex subunit G2
Gene namesi
Name:Ncapg2
Synonyms:Luzp5, Mtb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1923294. Ncapg2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11381138Condensin-2 complex subunit G2PRO_0000255943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301PhosphoserineBy similarity
Modified residuei1114 – 11141PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6DFV1.
PaxDbiQ6DFV1.
PRIDEiQ6DFV1.

PTM databases

PhosphoSiteiQ6DFV1.

Expressioni

Tissue specificityi

Expressed in spleen, lung and testis as well as in hematopoietic cell lines.1 Publication

Developmental stagei

Expressed form E7 when yolk sac hematopoiesis is initiated. Between E12.5 and E15.5 restricted to the developing fetal liver and the site of definitive hematopoiesis. Detected in thymus at E15.5 as well as the midbrain, forebrain and the olfactory epithelium.1 Publication

Gene expression databases

BgeeiQ6DFV1.
CleanExiMM_NCAPG2.
ExpressionAtlasiQ6DFV1. baseline and differential.
GenevestigatoriQ6DFV1.

Interactioni

Subunit structurei

Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2.

Protein-protein interaction databases

BioGridi217926. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6DFV1.
SMRiQ6DFV1. Positions 332-400, 459-485.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati459 – 49739HEATAdd
BLAST

Sequence similaritiesi

Contains 1 HEAT repeat.Curated

Phylogenomic databases

eggNOGiNOG261934.
GeneTreeiENSGT00490000043432.
HOGENOMiHOG000111841.
HOVERGENiHBG074124.
InParanoidiQ6DFV1.
KOiK11492.
OMAiTSKYWEM.
OrthoDBiEOG73V6N3.
TreeFamiTF101163.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024741. Condensin2_G2.
[Graphical view]
PfamiPF12422. Condensin2nSMC. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 4 hits.

Sequencei

Sequence statusi: Complete.

Q6DFV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKREAFIQA VSKELVEEFL QFLQLDKDSS NPFSLSELLD ELSRKQKEEL
60 70 80 90 100
WQRLKDLLTE TLLESPVDRW QTVEVEGADD MESEHSPKMR KSIKIICAIV
110 120 130 140 150
TVILASVSII NEHENYGALL ECAVILNGIL YALPESEQKL QNSIQDLCVK
160 170 180 190 200
WWERGLPAKE DMGKTAFIML LRRSLETKSG ADVCRLWRIH QALYCFDYDW
210 220 230 240 250
EESREIKDML LECFINVNYI KKEEGRRFLS FLFSWNVDFI KMIHETIKNQ
260 270 280 290 300
LAGLQKSLMV HIAEIYFRAW KKASGKMLET IEYDCIQDFM FHGIHLLRRS
310 320 330 340 350
PVHSKVREVL SYFHQQKVRQ GVEEMLYRLY KPILWRGLKA RNSEVRSNAA
360 370 380 390 400
LLFVEAFPIR DPNFTATEMD NEIQKQFEEL YNLIEDPYPR VRSTGILGVC
410 420 430 440 450
KISSKYWEMM PPNILVDFLK KVTGELAFDI SSADVRCSVF KCLPIILDNK
460 470 480 490 500
LSHPLLEQLL PTLRYSLHDN SEKVRVAFVD LLLKIKAVRA AKFWKICPME
510 520 530 540 550
DILVRLEMDS RPVSRRLVSL IFNSFLPVNQ PEEVWCERCV TLIQMNRAAA
560 570 580 590 600
RRFYQYAHEH TASTNIAKLI HVIRHCLNAC IQRTLREGSE AHKECEKENA
610 620 630 640 650
SVLDKTLSVN DTASMAGLLE IIVILWKNIH RSLENNKEAK IYTINKFAAV
660 670 680 690 700
LPEYLKVFKD ERCKIPLFML MSFLPASAVP VFSCGVISVL RNQESVTGRS
710 720 730 740 750
YCTLLDCLCS WGQVGHVLEL IVDWLPTVPP QAKSNLASKR KVEINDTCSV
760 770 780 790 800
KPELALLYME YLLTHPKNRE CLLSVPQKKL NQLLKALEGS KAELESFLQS
810 820 830 840 850
PSGNPLNFNK ATALHAFGLY CRMSVHLQYK FCSEEKIHLS ILDDTGSWLE
860 870 880 890 900
NKVLPLLEDQ EEEYLKLRKD VYQQIIQTYL AVCKDVVMVG LGDPKFQMQL
910 920 930 940 950
LQRSFGIMKT VKGFFYVSLL LGILKEIAGN TIIHKTDSDE KVTVLFDLVQ
960 970 980 990 1000
EVFQKMLECI ACIFRKQPEE SLPLFHSVQT PLHEFITTIQ SWHKDTAVHH
1010 1020 1030 1040 1050
AVLSTLIAAP VVEISHQLQK VSDIEELTSP QCLHDLPPFS RCLVGVIMKS
1060 1070 1080 1090 1100
SDVVRSFVDE LKACVTSGDV EGIVCLTAVL HIILVINKGK HISAKVKEVA
1110 1120 1130
TAVYRKLKTF MEITLEEDSL ERFLYESSMR TLGEFLNP
Length:1,138
Mass (Da):130,894
Last modified:July 27, 2011 - v2
Checksum:iB893DD92853AB1B5
GO

Sequence cautioni

The sequence AAH08539.1 differs from that shown. Reason: Frameshift at position 916. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti589 – 5891S → P in AAR21588. (PubMed:14729962)Curated
Sequence conflicti674 – 6741L → F in AAH76631. (PubMed:15489334)Curated
Sequence conflicti723 – 7231D → G in AAR21588. (PubMed:14729962)Curated
Sequence conflicti758 – 7581Y → C in AAR21588. (PubMed:14729962)Curated
Sequence conflicti1101 – 11011T → A in AAR21588. (PubMed:14729962)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160634 Genomic DNA. No translation available.
CT030173 Genomic DNA. No translation available.
BC008539 mRNA. Translation: AAH08539.1. Sequence problems.
BC076631 mRNA. Translation: AAH76631.1.
AY455829 mRNA. Translation: AAR21588.1.
CCDSiCCDS26212.1.
RefSeqiNP_598523.3. NM_133762.3.
XP_006516412.1. XM_006516349.1.
XP_006516413.1. XM_006516350.1.
XP_006516414.1. XM_006516351.1.
XP_006516415.1. XM_006516352.1.
XP_006516416.1. XM_006516353.1.
XP_006516417.1. XM_006516354.1.
UniGeneiMm.491196.

Genome annotation databases

EnsembliENSMUST00000084828; ENSMUSP00000081889; ENSMUSG00000042029.
GeneIDi76044.
KEGGimmu:76044.
UCSCiuc007pht.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC160634 Genomic DNA. No translation available.
CT030173 Genomic DNA. No translation available.
BC008539 mRNA. Translation: AAH08539.1 . Sequence problems.
BC076631 mRNA. Translation: AAH76631.1 .
AY455829 mRNA. Translation: AAR21588.1 .
CCDSi CCDS26212.1.
RefSeqi NP_598523.3. NM_133762.3.
XP_006516412.1. XM_006516349.1.
XP_006516413.1. XM_006516350.1.
XP_006516414.1. XM_006516351.1.
XP_006516415.1. XM_006516352.1.
XP_006516416.1. XM_006516353.1.
XP_006516417.1. XM_006516354.1.
UniGenei Mm.491196.

3D structure databases

ProteinModelPortali Q6DFV1.
SMRi Q6DFV1. Positions 332-400, 459-485.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 217926. 1 interaction.

PTM databases

PhosphoSitei Q6DFV1.

Proteomic databases

MaxQBi Q6DFV1.
PaxDbi Q6DFV1.
PRIDEi Q6DFV1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084828 ; ENSMUSP00000081889 ; ENSMUSG00000042029 .
GeneIDi 76044.
KEGGi mmu:76044.
UCSCi uc007pht.1. mouse.

Organism-specific databases

CTDi 54892.
MGIi MGI:1923294. Ncapg2.

Phylogenomic databases

eggNOGi NOG261934.
GeneTreei ENSGT00490000043432.
HOGENOMi HOG000111841.
HOVERGENi HBG074124.
InParanoidi Q6DFV1.
KOi K11492.
OMAi TSKYWEM.
OrthoDBi EOG73V6N3.
TreeFami TF101163.

Enzyme and pathway databases

Reactomei REACT_196580. Condensation of Prophase Chromosomes.

Miscellaneous databases

ChiTaRSi Ncapg2. mouse.
NextBioi 344499.
PROi Q6DFV1.
SOURCEi Search...

Gene expression databases

Bgeei Q6DFV1.
CleanExi MM_NCAPG2.
ExpressionAtlasi Q6DFV1. baseline and differential.
Genevestigatori Q6DFV1.

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024741. Condensin2_G2.
[Graphical view ]
Pfami PF12422. Condensin2nSMC. 2 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 4 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and Czech II.
    Tissue: Head and Mammary gland.
  3. "More than blood, a novel gene required for mammalian postimplantation development."
    Smith E.D., Xu Y., Tomson B.N., Leung C.G., Fujiwara Y., Orkin S.H., Crispino J.D.
    Mol. Cell. Biol. 24:1168-1173(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 207-1138, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: 129/Sv.

Entry informationi

Entry nameiCNDG2_MOUSE
AccessioniPrimary (citable) accession number: Q6DFV1
Secondary accession number(s): E9QP71, Q6SLL0, Q922D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3