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Q6DFR2

- CBLB_XENTR

UniProt

Q6DFR2 - CBLB_XENTR

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Protein

E3 ubiquitin-protein ligase CBL-B

Gene
cblb
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei297 – 2971Phosphotyrosine By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi230 – 24314 By similarityAdd
BLAST
Zinc fingeri384 – 42340RING-typeAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. ligase activity Source: UniProtKB-KW
  3. signal transducer activity Source: InterPro
  4. ubiquitin-protein transferase activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell surface receptor signaling pathway Source: InterPro
  2. regulation of signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase CBL-B (EC:6.3.2.-)
Alternative name(s):
SH3-binding protein CBL-B
Signal transduction protein CBL-B
Gene namesi
Name:cblb
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1018102. cblb.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982E3 ubiquitin-protein ligase CBL-BPRO_0000055865Add
BLAST

Proteomic databases

PRIDEiQ6DFR2.

Interactioni

Subunit structurei

Interacts with several SH3 domain-containing proteins and with poly-ubiquitinated proteins By similarity.

Protein-protein interaction databases

STRINGi8364.ENSXETP00000035178.

Structurei

3D structure databases

ProteinModelPortaliQ6DFR2.
SMRiQ6DFR2. Positions 46-437, 930-972.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 354309Cbl-PTBAdd
BLAST
Domaini927 – 97044UBAAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 1781334HAdd
BLAST
Regioni179 – 25173EF-hand-likeAdd
BLAST
Regioni252 – 354103SH2-likeAdd
BLAST
Regioni355 – 38329LinkerAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi487 – 57690Pro-richAdd
BLAST
Compositional biasi683 – 6886Poly-Pro
Compositional biasi813 – 915103Pro-richAdd
BLAST

Domaini

The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme By similarity.
The UBA domain interacts with poly-ubiquitinated proteins By similarity.

Sequence similaritiesi

Contains 1 UBA domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG242251.
HOVERGENiHBG005255.
KOiK04707.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00252. SH2. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DFR2-1 [UniParc]FASTAAdd to Basket

« Hide

MASSSSSSSS TNSSAVTGRL PGARSANPRK ARILGLFDAI QDAVGPPKQA    50
AADRRTVEKT WKLMDKVVRL CQNPKLQLKN SPPYILDILP DTYQHLRLIL 100
SKYDDNQKLA QLSENEYFKI YIDSLMKKSK RAIRLFKEGK ERMYEEQSQE 150
RRNLTKLSLI FSHMLAEIKA IFPSGQFQGD NFRITKADAA EFWRKFFGER 200
TIVPWKIFRQ CLHEVHQISS GLEAMALKST IDLTCNDYIS VFEFDIFTRL 250
FQPWTSILRN WNFLAVTHPG YMAFLTYDEV KARLQKYSTK PGSYIFRLSC 300
TRLGQWAIGY VTADGNILQT IPHNKPLFQA LIDGSREGFY LYPDGRSYNP 350
DLTDLCEPTP HDHIKVTQEQ YELYCEMGST FQLCKICAEN DKDVKIEPCG 400
HLMCTSCLTS WQESDGQGCP FCRCEIKGTE PIVVDPFDPR DENRCCSFND 450
SLCTPMLDFD DDDLREECLI MNRLASLRKM NERQNSPVTS PGSSPLSQRR 500
KTPPDPLQIP HLNLPPVPPR LDLIQKGLAR SPCASPTGSP KSSPCMVRKQ 550
DKPLPAPPPP LREPPPPPER PPPIPPDSRT CRHLHHTENV PCRDQSTQHD 600
AWCTRDISGA SQPSICRVAH DGSPKLGVPS SSVLNGRHSR MSTEAGFIRH 650
KHHKRRESPL ETIRVYNGLS GNEEYDVPPR LSPPPPPPTI TIHPAIKCPL 700
LVNSVSDKVR NSAEEDDSEY KIPSSHPVSS RLPLHCHSIK HFPRLCENGQ 750
CLSNGTHNGI SEIKKLKQPD QGDVIATSTV PVPLPSARTS ARENHPHGSS 800
LTRTPSDYDL LVPHPGEESF DSSPPSQPPP PPPARTCVPE HAMPTASGCR 850
PNSDVDLFLP HSDPCPEAPL PPARRGPGEA KSNRLSQEYD QLPSCPDCPQ 900
APARPPKPVP RRTAPEIHHR RHYNCDSLAE NVDAKIAKLM GEGFPFEEVK 950
RALEIAQNNV DVARSILREF AFPPPVCPRL HL 982
Length:982
Mass (Da):110,118
Last modified:August 16, 2004 - v1
Checksum:iB55D0D9C0F0658A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC076671 mRNA. Translation: AAH76671.1.
RefSeqiNP_001006802.1. NM_001006801.1.
UniGeneiStr.5685.

Genome annotation databases

GeneIDi448509.
KEGGixtr:448509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC076671 mRNA. Translation: AAH76671.1 .
RefSeqi NP_001006802.1. NM_001006801.1.
UniGenei Str.5685.

3D structure databases

ProteinModelPortali Q6DFR2.
SMRi Q6DFR2. Positions 46-437, 930-972.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000035178.

Proteomic databases

PRIDEi Q6DFR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 448509.
KEGGi xtr:448509.

Organism-specific databases

CTDi 868.
Xenbasei XB-GENE-1018102. cblb.

Phylogenomic databases

eggNOGi NOG242251.
HOVERGENi HBG005255.
KOi K04707.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
PANTHERi PTHR23007. PTHR23007. 1 hit.
Pfami PF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00252. SH2. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCBLB_XENTR
AccessioniPrimary (citable) accession number: Q6DFR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has one functional calcium-binding site By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi