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Q6DFR2

- CBLB_XENTR

UniProt

Q6DFR2 - CBLB_XENTR

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Protein

E3 ubiquitin-protein ligase CBL-B

Gene

cblb

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei297 – 2971PhosphotyrosineBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi230 – 24314PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 42340RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. ligase activity Source: UniProtKB-KW
  3. signal transducer activity Source: InterPro
  4. ubiquitin-protein transferase activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell surface receptor signaling pathway Source: InterPro
  2. regulation of signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase CBL-B (EC:6.3.2.-)
Alternative name(s):
SH3-binding protein CBL-B
Signal transduction protein CBL-B
Gene namesi
Name:cblb
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1018102. cblb.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982E3 ubiquitin-protein ligase CBL-BPRO_0000055865Add
BLAST

Proteomic databases

PRIDEiQ6DFR2.

Interactioni

Subunit structurei

Interacts with several SH3 domain-containing proteins and with poly-ubiquitinated proteins.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000035178.

Structurei

3D structure databases

ProteinModelPortaliQ6DFR2.
SMRiQ6DFR2. Positions 46-437, 930-972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 354309Cbl-PTBPROSITE-ProRule annotationAdd
BLAST
Domaini927 – 97044UBAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni46 – 1781334HAdd
BLAST
Regioni179 – 25173EF-hand-likeAdd
BLAST
Regioni252 – 354103SH2-likeAdd
BLAST
Regioni355 – 38329LinkerAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi487 – 57690Pro-richAdd
BLAST
Compositional biasi683 – 6886Poly-Pro
Compositional biasi813 – 915103Pro-richAdd
BLAST

Domaini

The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.By similarity
The UBA domain interacts with poly-ubiquitinated proteins.By similarity

Sequence similaritiesi

Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri384 – 42340RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG242251.
HOVERGENiHBG005255.
InParanoidiQ6DFR2.
KOiK04707.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PANTHERiPTHR23007. PTHR23007. 1 hit.
PfamiPF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
SM00252. SH2. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DFR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASSSSSSSS TNSSAVTGRL PGARSANPRK ARILGLFDAI QDAVGPPKQA
60 70 80 90 100
AADRRTVEKT WKLMDKVVRL CQNPKLQLKN SPPYILDILP DTYQHLRLIL
110 120 130 140 150
SKYDDNQKLA QLSENEYFKI YIDSLMKKSK RAIRLFKEGK ERMYEEQSQE
160 170 180 190 200
RRNLTKLSLI FSHMLAEIKA IFPSGQFQGD NFRITKADAA EFWRKFFGER
210 220 230 240 250
TIVPWKIFRQ CLHEVHQISS GLEAMALKST IDLTCNDYIS VFEFDIFTRL
260 270 280 290 300
FQPWTSILRN WNFLAVTHPG YMAFLTYDEV KARLQKYSTK PGSYIFRLSC
310 320 330 340 350
TRLGQWAIGY VTADGNILQT IPHNKPLFQA LIDGSREGFY LYPDGRSYNP
360 370 380 390 400
DLTDLCEPTP HDHIKVTQEQ YELYCEMGST FQLCKICAEN DKDVKIEPCG
410 420 430 440 450
HLMCTSCLTS WQESDGQGCP FCRCEIKGTE PIVVDPFDPR DENRCCSFND
460 470 480 490 500
SLCTPMLDFD DDDLREECLI MNRLASLRKM NERQNSPVTS PGSSPLSQRR
510 520 530 540 550
KTPPDPLQIP HLNLPPVPPR LDLIQKGLAR SPCASPTGSP KSSPCMVRKQ
560 570 580 590 600
DKPLPAPPPP LREPPPPPER PPPIPPDSRT CRHLHHTENV PCRDQSTQHD
610 620 630 640 650
AWCTRDISGA SQPSICRVAH DGSPKLGVPS SSVLNGRHSR MSTEAGFIRH
660 670 680 690 700
KHHKRRESPL ETIRVYNGLS GNEEYDVPPR LSPPPPPPTI TIHPAIKCPL
710 720 730 740 750
LVNSVSDKVR NSAEEDDSEY KIPSSHPVSS RLPLHCHSIK HFPRLCENGQ
760 770 780 790 800
CLSNGTHNGI SEIKKLKQPD QGDVIATSTV PVPLPSARTS ARENHPHGSS
810 820 830 840 850
LTRTPSDYDL LVPHPGEESF DSSPPSQPPP PPPARTCVPE HAMPTASGCR
860 870 880 890 900
PNSDVDLFLP HSDPCPEAPL PPARRGPGEA KSNRLSQEYD QLPSCPDCPQ
910 920 930 940 950
APARPPKPVP RRTAPEIHHR RHYNCDSLAE NVDAKIAKLM GEGFPFEEVK
960 970 980
RALEIAQNNV DVARSILREF AFPPPVCPRL HL
Length:982
Mass (Da):110,118
Last modified:August 16, 2004 - v1
Checksum:iB55D0D9C0F0658A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC076671 mRNA. Translation: AAH76671.1.
RefSeqiNP_001006802.1. NM_001006801.1.
UniGeneiStr.5685.

Genome annotation databases

GeneIDi448509.
KEGGixtr:448509.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC076671 mRNA. Translation: AAH76671.1 .
RefSeqi NP_001006802.1. NM_001006801.1.
UniGenei Str.5685.

3D structure databases

ProteinModelPortali Q6DFR2.
SMRi Q6DFR2. Positions 46-437, 930-972.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000035178.

Proteomic databases

PRIDEi Q6DFR2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 448509.
KEGGi xtr:448509.

Organism-specific databases

CTDi 868.
Xenbasei XB-GENE-1018102. cblb.

Phylogenomic databases

eggNOGi NOG242251.
HOVERGENi HBG005255.
InParanoidi Q6DFR2.
KOi K04707.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
1.20.930.20. 1 hit.
3.30.40.10. 1 hit.
3.30.505.10. 1 hit.
InterProi IPR024162. Adaptor_Cbl.
IPR014741. Adaptor_Cbl_EF_hand-like.
IPR003153. Adaptor_Cbl_N_hlx.
IPR014742. Adaptor_Cbl_SH2-like.
IPR024159. Cbl_PTB.
IPR011992. EF-hand-dom_pair.
IPR000980. SH2.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR000449. UBA/Ts_N.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
PANTHERi PTHR23007. PTHR23007. 1 hit.
Pfami PF02262. Cbl_N. 1 hit.
PF02761. Cbl_N2. 1 hit.
PF02762. Cbl_N3. 1 hit.
PF00627. UBA. 1 hit.
[Graphical view ]
SMARTi SM00184. RING. 1 hit.
SM00252. SH2. 1 hit.
SM00165. UBA. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF47668. SSF47668. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEi PS51506. CBL_PTB. 1 hit.
PS50030. UBA. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiCBLB_XENTR
AccessioniPrimary (citable) accession number: Q6DFR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has one functional calcium-binding site.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3