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Protein

Serine/threonine-protein kinase TBK1

Gene

tbk1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine protein probably involved in innate immune response.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381ATPPROSITE-ProRule annotation
Active sitei135 – 1351Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 239ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase TBK1 (EC:2.7.11.1)
Gene namesi
Name:tbk1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-955455. tbk1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 725725Serine/threonine-protein kinase TBK1PRO_0000086745Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi103211. 1 interaction.
IntActiQ6DFJ6. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6DFJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 306298Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini309 – 38577Ubiquitin-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili635 – 70975Sequence analysisAdd
BLAST

Domaini

Comprises A N-terminal kinase domain, a ubiquitin-like domain and a C-terminal coiled-coil region mediating homodimerization.By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG008494.
KOiK05410.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DFJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSTANYLWM LSDILGQGAT ANVYRGRNKK TGDLYAVKVF NSLSFQRPAD
60 70 80 90 100
VQMREFEVLK KLNHKNIVKL FAIEEEMSSR HKVLVMEFCP CASLYSVLEE
110 120 130 140 150
PTNSYGLPES EFLIVSRDVV AGMNHLRENG IIHRDIKPGN IMREIGEDGK
160 170 180 190 200
SVYKLTDFGA ARELEDDEQF VSLYGTEEYL HPDMYERAVL RKEHQKKYSA
210 220 230 240 250
TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIIAG KPSGAISGVQ
260 270 280 290 300
RAENGPIEWS GELPATCNLS MGLQTLFTPV LANILEADQE KCWGFEQFFA
310 320 330 340 350
VTNDIFNRIV VHVFSLQQMT PHKIYINTYD KVPDFHDLVY KQTKIPGQNQ
360 370 380 390 400
ELLFEGRRLV LEQGRLAQHF PITTDENPIF VLTREMVSVI GLRFDEIVIP
410 420 430 440 450
KPISHYDLDV DANMAKAVTG VACYYCRIAA SLLLVLDLMR KGIRWLSELM
460 470 480 490 500
KEEYNENVHR NTEVSLKLNF CNRTTEKDLK IYEQLMQTSV ESEVYAIHAK
510 520 530 540 550
LLNLSSTQEG LKSSLQEVKN KLTPGGTLMD SWINTEGIHA ADRNVEKLQV
560 570 580 590 600
LLSLITEIYC QFKKDKAQRR LSYNEEQIHK FDKQKLCLHA AKAYSLFKDE
610 620 630 640 650
CVGKYEVFRS KTLEWMRKMI HVRKQLFSIK SKCFDIEEEA SKCQHYINQY
660 670 680 690 700
QEKMSPKMFA APSGMKSAVN PIYSSPNTLV EMTLGMRKLK EDMEGVVKEL
710 720
EENNHILERF GALTIDGDFR NVDCI
Length:725
Mass (Da):83,271
Last modified:August 16, 2004 - v1
Checksum:i0264EC5A270D12EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076740 mRNA. Translation: AAH76740.1.
RefSeqiNP_001086516.1. NM_001093047.1.
UniGeneiXl.25092.

Genome annotation databases

GeneIDi446351.
KEGGixla:446351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076740 mRNA. Translation: AAH76740.1.
RefSeqiNP_001086516.1. NM_001093047.1.
UniGeneiXl.25092.

3D structure databases

ProteinModelPortaliQ6DFJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi103211. 1 interaction.
IntActiQ6DFJ6. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi446351.
KEGGixla:446351.

Organism-specific databases

CTDi29110.
XenbaseiXB-GENE-955455. tbk1.

Phylogenomic databases

HOVERGENiHBG008494.
KOiK05410.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBK1_XENLA
AccessioniPrimary (citable) accession number: Q6DFJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.