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Protein

Serine/threonine-protein kinase TBK1

Gene

tbk1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine/threonine protein probably involved in innate immune response.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38ATPPROSITE-ProRule annotation1
Active sitei135Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processImmunity, Innate immunity
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase TBK1 (EC:2.7.11.1)
Gene namesi
Name:tbk1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-955455 tbk1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867451 – 725Serine/threonine-protein kinase TBK1Add BLAST725

Proteomic databases

PRIDEiQ6DFJ6

Interactioni

Protein-protein interaction databases

BioGridi103211, 1 interactor
IntActiQ6DFJ6, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6DFJ6
SMRiQ6DFJ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 306Protein kinasePROSITE-ProRule annotationAdd BLAST298
Domaini309 – 385Ubiquitin-likeAdd BLAST77

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili635 – 709Sequence analysisAdd BLAST75

Domaini

Comprises A N-terminal kinase domain, a ubiquitin-like domain and a C-terminal coiled-coil region mediating homodimerization.By similarity

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG008494
KOiK05410

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DFJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSTANYLWM LSDILGQGAT ANVYRGRNKK TGDLYAVKVF NSLSFQRPAD
60 70 80 90 100
VQMREFEVLK KLNHKNIVKL FAIEEEMSSR HKVLVMEFCP CASLYSVLEE
110 120 130 140 150
PTNSYGLPES EFLIVSRDVV AGMNHLRENG IIHRDIKPGN IMREIGEDGK
160 170 180 190 200
SVYKLTDFGA ARELEDDEQF VSLYGTEEYL HPDMYERAVL RKEHQKKYSA
210 220 230 240 250
TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIIAG KPSGAISGVQ
260 270 280 290 300
RAENGPIEWS GELPATCNLS MGLQTLFTPV LANILEADQE KCWGFEQFFA
310 320 330 340 350
VTNDIFNRIV VHVFSLQQMT PHKIYINTYD KVPDFHDLVY KQTKIPGQNQ
360 370 380 390 400
ELLFEGRRLV LEQGRLAQHF PITTDENPIF VLTREMVSVI GLRFDEIVIP
410 420 430 440 450
KPISHYDLDV DANMAKAVTG VACYYCRIAA SLLLVLDLMR KGIRWLSELM
460 470 480 490 500
KEEYNENVHR NTEVSLKLNF CNRTTEKDLK IYEQLMQTSV ESEVYAIHAK
510 520 530 540 550
LLNLSSTQEG LKSSLQEVKN KLTPGGTLMD SWINTEGIHA ADRNVEKLQV
560 570 580 590 600
LLSLITEIYC QFKKDKAQRR LSYNEEQIHK FDKQKLCLHA AKAYSLFKDE
610 620 630 640 650
CVGKYEVFRS KTLEWMRKMI HVRKQLFSIK SKCFDIEEEA SKCQHYINQY
660 670 680 690 700
QEKMSPKMFA APSGMKSAVN PIYSSPNTLV EMTLGMRKLK EDMEGVVKEL
710 720
EENNHILERF GALTIDGDFR NVDCI
Length:725
Mass (Da):83,271
Last modified:August 16, 2004 - v1
Checksum:i0264EC5A270D12EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC076740 mRNA Translation: AAH76740.1
RefSeqiNP_001086516.1, NM_001093047.1
UniGeneiXl.25092

Genome annotation databases

GeneIDi446351
KEGGixla:446351

Similar proteinsi

Entry informationi

Entry nameiTBK1_XENLA
AccessioniPrimary (citable) accession number: Q6DFJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health