Wee1-like protein kinase 2-C - Xenopus laevis (African clawed frog)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Wee1-like protein kinase 2-C
EC=2.7.10.2

Gene names

Name:

wee2-c

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	554 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a regulator of meiosis in oocytes. Required to ensure the meiotic cell cycle in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiosis By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Meiosis
Cellular component	Nucleus
Domain	Coiled coil
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
Gene Ontology (GO)
Biological_process	meiosis Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW magnesium ion binding Inferred from electronic annotation. Source: InterPro non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 554

554

Wee1-like protein kinase 2-C

PRO_0000409530

Regions

Domain

213 – 487

275

Protein kinase

Nucleotide binding

219 – 227

9

ATP By similarity

Coiled coil

490 – 516

27

Potential

Sites

Active site

340

1

Proton acceptor By similarity

Metal binding

345

1

Magnesium; via carbonyl oxygen By similarity

Metal binding

377

1

Magnesium; via carbonyl oxygen By similarity

Binding site

242

1

ATP By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q6DFE0 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: EFE3B011E2E66E06
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FASTA

554

61,412

        10         20         30         40         50         60 
MRTAMSCGGG LVQRLDFSSS EEEDGLSNGI NEAPQKGSPV SSWRTNNCPF PITPQRNERG 

        70         80         90        100        110        120 
LSPTQELSPS SDYSPDPSDK GAGGECPGTP LHYSTWKKLK LCDTPYTPKS LLYKTLPSPG 

       130        140        150        160        170        180 
SRVHCRGQRL LRFVAGTGAE TEDPTLVNVN PFTPQSYRQT HFQPNGKRKE RPEDDCSSDS 

       190        200        210        220        230        240 
QMKFTDKEHP SVFQSKRFVL RETNMESRYK TEFLEIEKIG AGEFGSVFKC VKRLDGCFYV 

       250        260        270        280        290        300 
IKRSKKPLAG STDEQLALRE VYAHAVLGHH PHVVRYYSAW AEDDHMIIQN EYCNGGSLQD 

       310        320        330        340        350        360 
LIMENNKKGQ FVPEQELKEI LLQVSMGLKY IHGSGLVHMD IKPSNIFICR KQTEVGEDES 

       370        380        390        400        410        420 
DGEDDVSSAS VLYKIGDLGH VTSILNPQVE EGDSRFLANE ILQEDYRQLP KADIFALGLT 

       430        440        450        460        470        480 
IALAAGAAPL PCNEDGWHHI RKGNLPHIPQ PLTPAFLALL KLLVHPDPAT RPPAASLAKN 

       490        500        510        520        530        540 
SVLRRCVGKA AELQKQLNVE KFKTAMLERE LQAAKLAQDE CLDLPPVSGF SCRGRKRLVG 

       550 
AKNARSLSFT CGGY

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References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Oocyte.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC076799 mRNA. Translation: AAH76799.1.
3D structure databases
ProteinModelPortal	Q6DFE0.
SMR	Q6DFE0. Positions 205-483.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG005050.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. IPR017164. Wee1-like_protein_kinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PIRSF	PIRSF037281. Wee1-like_protein_kinase. 1 hit.
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

WEE2C_XENLA

Accession

Primary (citable) accession number: Q6DFE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 31, 2011
Last sequence update:	August 16, 2004
Last modified:	July 11, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families