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Q6DFE0

- WEE2C_XENLA

UniProt

Q6DFE0 - WEE2C_XENLA

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Protein

Wee1-like protein kinase 2-C

Gene

wee2-c

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a regulator of meiosis in oocytes. Required to ensure the meiotic cell cycle in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiosis (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421ATPPROSITE-ProRule annotation
Active sitei340 – 3401Proton acceptorPROSITE-ProRule annotation
Metal bindingi345 – 3451Magnesium; via carbonyl oxygenBy similarity
Metal bindingi377 – 3771Magnesium; via carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi219 – 2279ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  4. protein serine/threonine kinase activity Source: InterPro

GO - Biological processi

  1. meiotic nuclear division Source: UniProtKB-KW
  2. mitotic nuclear division Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Meiosis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Wee1-like protein kinase 2-C (EC:2.7.10.2)
Gene namesi
Name:wee2-c
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 554554Wee1-like protein kinase 2-CPRO_0000409530Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6DFE0.
SMRiQ6DFE0. Positions 205-483.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini213 – 487275Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili490 – 51627Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG005050.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR017164. Wee1-like_protein_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037281. Wee1-like_protein_kinase. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DFE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTAMSCGGG LVQRLDFSSS EEEDGLSNGI NEAPQKGSPV SSWRTNNCPF
60 70 80 90 100
PITPQRNERG LSPTQELSPS SDYSPDPSDK GAGGECPGTP LHYSTWKKLK
110 120 130 140 150
LCDTPYTPKS LLYKTLPSPG SRVHCRGQRL LRFVAGTGAE TEDPTLVNVN
160 170 180 190 200
PFTPQSYRQT HFQPNGKRKE RPEDDCSSDS QMKFTDKEHP SVFQSKRFVL
210 220 230 240 250
RETNMESRYK TEFLEIEKIG AGEFGSVFKC VKRLDGCFYV IKRSKKPLAG
260 270 280 290 300
STDEQLALRE VYAHAVLGHH PHVVRYYSAW AEDDHMIIQN EYCNGGSLQD
310 320 330 340 350
LIMENNKKGQ FVPEQELKEI LLQVSMGLKY IHGSGLVHMD IKPSNIFICR
360 370 380 390 400
KQTEVGEDES DGEDDVSSAS VLYKIGDLGH VTSILNPQVE EGDSRFLANE
410 420 430 440 450
ILQEDYRQLP KADIFALGLT IALAAGAAPL PCNEDGWHHI RKGNLPHIPQ
460 470 480 490 500
PLTPAFLALL KLLVHPDPAT RPPAASLAKN SVLRRCVGKA AELQKQLNVE
510 520 530 540 550
KFKTAMLERE LQAAKLAQDE CLDLPPVSGF SCRGRKRLVG AKNARSLSFT

CGGY
Length:554
Mass (Da):61,412
Last modified:August 16, 2004 - v1
Checksum:iEFE3B011E2E66E06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC076799 mRNA. Translation: AAH76799.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC076799 mRNA. Translation: AAH76799.1 .

3D structure databases

ProteinModelPortali Q6DFE0.
SMRi Q6DFE0. Positions 205-483.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005050.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR017164. Wee1-like_protein_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF037281. Wee1-like_protein_kinase. 1 hit.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Oocyte.

Entry informationi

Entry nameiWEE2C_XENLA
AccessioniPrimary (citable) accession number: Q6DFE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3