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Q6DFE0 (WEE2C_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Wee1-like protein kinase 2-C

EC=2.7.10.2
Gene names
Name:wee2-c
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length554 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein tyrosine kinase that phosphorylates and inhibits cdk1 and acts as a regulator of meiosis in oocytes. Required to ensure the meiotic cell cycle in oocytes by phosphorylating cdk1 at 'Tyr-15', leading to inhibit cdk1 activity and prevent meiosis By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 554554Wee1-like protein kinase 2-C
PRO_0000409530

Regions

Domain213 – 487275Protein kinase
Nucleotide binding219 – 2279ATP By similarity
Coiled coil490 – 51627 Potential

Sites

Active site3401Proton acceptor By similarity
Metal binding3451Magnesium; via carbonyl oxygen By similarity
Metal binding3771Magnesium; via carbonyl oxygen By similarity
Binding site2421ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6DFE0 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: EFE3B011E2E66E06

FASTA55461,412
        10         20         30         40         50         60 
MRTAMSCGGG LVQRLDFSSS EEEDGLSNGI NEAPQKGSPV SSWRTNNCPF PITPQRNERG 

        70         80         90        100        110        120 
LSPTQELSPS SDYSPDPSDK GAGGECPGTP LHYSTWKKLK LCDTPYTPKS LLYKTLPSPG 

       130        140        150        160        170        180 
SRVHCRGQRL LRFVAGTGAE TEDPTLVNVN PFTPQSYRQT HFQPNGKRKE RPEDDCSSDS 

       190        200        210        220        230        240 
QMKFTDKEHP SVFQSKRFVL RETNMESRYK TEFLEIEKIG AGEFGSVFKC VKRLDGCFYV 

       250        260        270        280        290        300 
IKRSKKPLAG STDEQLALRE VYAHAVLGHH PHVVRYYSAW AEDDHMIIQN EYCNGGSLQD 

       310        320        330        340        350        360 
LIMENNKKGQ FVPEQELKEI LLQVSMGLKY IHGSGLVHMD IKPSNIFICR KQTEVGEDES 

       370        380        390        400        410        420 
DGEDDVSSAS VLYKIGDLGH VTSILNPQVE EGDSRFLANE ILQEDYRQLP KADIFALGLT 

       430        440        450        460        470        480 
IALAAGAAPL PCNEDGWHHI RKGNLPHIPQ PLTPAFLALL KLLVHPDPAT RPPAASLAKN 

       490        500        510        520        530        540 
SVLRRCVGKA AELQKQLNVE KFKTAMLERE LQAAKLAQDE CLDLPPVSGF SCRGRKRLVG 

       550 
AKNARSLSFT CGGY 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Oocyte.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC076799 mRNA. Translation: AAH76799.1.

3D structure databases

ProteinModelPortalQ6DFE0.
SMRQ6DFE0. Positions 205-483.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005050.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR017164. Wee1-like_protein_kinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF037281. Wee1-like_protein_kinase. 1 hit.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameWEE2C_XENLA
AccessionPrimary (citable) accession number: Q6DFE0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 31, 2011
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families