Reviewed, UniProtKB/Swiss-Prot Q6DF30 (DHDH_XENTR)

Names and origin

Protein names

Recommended name:
    Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
    EC=1.3.1.20
Alternative name(s):
    Dimeric dihydrodiol dehydrogenase
    D-xylose-NADP dehydrogenase
    EC=1.1.1.179
    D-xylose 1-dehydrogenase

Gene names

Name:

dhdh

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH. D-xylose + NADP+ = D-xylono-1,5-lactone + NADPH.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-xylose 1-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 330	330	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase		PRO_0000315370
Sites
	Site	71	1	May play an important role in coenzyme binding By similarity
	Site	79	1	May play an important role in coenzyme binding By similarity
	Site	97	1	May play an important role in coenzyme binding By similarity
	Site	176	1	May play an important role for the adaptation of the alcohol substrate into the binding site By similarity
	Site	180	1	May play an important role in catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6DF30-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 6363E88F2B298EAA	FASTA	330	36,310
	10 20 30 40 50 60 MATKWGICSA GKISNDFVVA LSTLPAVDHQ VVAIAARDLE KAKNFAQNHN IPKAYGSYEE 70 80 90 100 110 120 LAKDPDIDVI YVGAIHPVHR DVVLMCLQNG KNILCEKPLA MNAAQVQELI ATARKFNVFL 130 140 150 160 170 180 MEAFWSRFFP VYEEIRALLS QKAIGDVKFI RAEFGVEIYK VPRAVEKELG GGALLDIGCY 190 200 210 220 230 240 CVQFVTMVFN GERPESVTAK GFLHETGVDE SMSLILQYSG KRQAVLSSTI MATLPNQAAI 250 260 270 280 290 300 CGTKGIIQIP SDMWSPTSII VNGKERKFDI PHTTKPMNFS NGTGMSYEAE HVRQCLLKGL 310 320 330 KESPIMSLAD SEMVASIMDE ALQQLGVTYP

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC076913 mRNA. Translation: AAH76913.1.
RefSeq	NP_001005045.1.
UniGene	Str.8642
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6DF30.
Genome annotation databases
Ensembl	ENSXETT00000057315; ENSXETP00000057315; ENSXETG00000027480; Xenopus tropicalis. [Genome view]
GeneID	448579.
KEGG	xtr:448579.
Organism-specific databases
CTD	448579.
Xenbase	XB-FEAT-968485.
Phylogenomic databases
HOGENOM	Q6DF30.
HOVERGEN	Q6DF30.
OMA	NILCEKP.
Enzyme and pathway databases
BRENDA	1.1.1.179. 279072. 1.3.1.20. 279072.
Gene expression databases
Bgee	Q6DF30.
Family and domain databases
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHDH_XENTR

Accession

Primary (citable) accession number: Q6DF30

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 16, 2004
Last modified:	November 3, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project