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Protein
Submitted name:

Aquaporin-0a

Gene

mipa

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glycerol channel activity Source: GO_Central
  • water channel activity Source: ZFIN
  • water transmembrane transporter activity Source: ZFIN

GO - Biological processi

  • cellular water homeostasis Source: GO_Central
  • ion transmembrane transport Source: GO_Central
  • lens development in camera-type eye Source: ZFIN
  • water transport Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-432047. Passive transport by Aquaporins.

Names & Taxonomyi

Protein namesi
Submitted name:
Aquaporin-0aImported
Submitted name:
Major intrinsic protein of lens fiber 1Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:mipaImported
Synonyms:mip1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 23

Organism-specific databases

ZFINiZDB-GENE-040801-41. mipa.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 35HelicalSequence analysisAdd BLAST24
Transmembranei41 – 62HelicalSequence analysisAdd BLAST22
Transmembranei83 – 105HelicalSequence analysisAdd BLAST23
Transmembranei125 – 148HelicalSequence analysisAdd BLAST24
Transmembranei160 – 179HelicalSequence analysisAdd BLAST20
Transmembranei202 – 224HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000037285.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054237.

Family & Domainsi

Sequence similaritiesi

Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
KOiK09863.
OMAiAQQETRG.
OrthoDBiEOG091G166T.
TreeFamiTF312940.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DEI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWEFRSMSFW RAVFAEFYGT MFFVFFGLGA ALRWTTGPHN VLQVAFCFGL
60 70 80 90 100
AAATFIQSIG HISGGHINPA VTFAYLIGSQ MSLFRAFFYI CAQCLGALAG
110 120 130 140 150
AAVLYGVTPT NMRGNLALNT LQPGISMGMA TTIEIFLTLQ LVVCVFAVTD
160 170 180 190 200
ERRNGRLGSA ALSIGFSVLV GHLLGMYYTG AGMNPARSFA PAVLYRNFIN
210 220 230 240 250
HWVYWVGPMI GAAMGALLYD FMLFPRVRGL SERLAVLKGN KPTEPEAQQE
260
TRGEPIELKT QAL
Length:263
Mass (Da):28,784
Last modified:August 16, 2004 - v1
Checksum:i91A27E007BF8D048
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR354433 Genomic DNA. No translation available.
BC077129 mRNA. Translation: AAH77129.1.
FJ666326 mRNA. Translation: ACV73793.1.
RefSeqiNP_001003534.1. NM_001003534.1.
UniGeneiDr.90943.

Genome annotation databases

EnsembliENSDART00000054238; ENSDARP00000054237; ENSDARG00000037285.
GeneIDi445140.
KEGGidre:445140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR354433 Genomic DNA. No translation available.
BC077129 mRNA. Translation: AAH77129.1.
FJ666326 mRNA. Translation: ACV73793.1.
RefSeqiNP_001003534.1. NM_001003534.1.
UniGeneiDr.90943.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000054237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000054238; ENSDARP00000054237; ENSDARG00000037285.
GeneIDi445140.
KEGGidre:445140.

Organism-specific databases

CTDi445140.
ZFINiZDB-GENE-040801-41. mipa.

Phylogenomic databases

eggNOGiKOG0223. Eukaryota.
COG0580. LUCA.
GeneTreeiENSGT00760000119223.
HOGENOMiHOG000288286.
HOVERGENiHBG000312.
KOiK09863.
OMAiAQQETRG.
OrthoDBiEOG091G166T.
TreeFamiTF312940.

Enzyme and pathway databases

ReactomeiR-DRE-432047. Passive transport by Aquaporins.

Gene expression databases

BgeeiENSDARG00000037285.

Family and domain databases

CDDicd00333. MIP. 1 hit.
Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR000425. MIP.
IPR022357. MIP_CS.
[Graphical view]
PANTHERiPTHR19139. PTHR19139. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PRINTSiPR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
TIGRFAMsiTIGR00861. MIP. 1 hit.
PROSITEiPS00221. MIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6DEI6_DANRE
AccessioniPrimary (citable) accession number: Q6DEI6
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.