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Q6DEH3 (KC2D1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Calcium/calmodulin-dependent protein kinase type II delta 1 chain
EC=2.7.11.17
Alternative name(s):
Calcium/calmodulin-dependent protein kinase type II delta-B chain
Short name=CaM kinase II subunit delta-B
Short name=CaM-kinase II delta-B chain
Short name=CaMK-II subunit delta-B
Gene names
Name:camk2d1
Synonyms:camk2db
ORF Names:zgc:101001, zgc:173815
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system By similarity. Ref.2

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation

Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity By similarity. Ref.2

Subunit structure

CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits By similarity. Ref.2

Tissue specificity

First detected at the 18-somite stage where expression is restricted to somite boundaries. At 24 hpf, expression is elevated in epidermal tissue and in the hatching gland. After 24 hpf, expression dimishes, but persists at low levels along the dorsal trunk. At 48 hpf, expression is restricted at a low level to the forebrain. At 72 hpf, weak expression reappears along the entire dorsal trunk in discrete cell bodies. Ref.2

Sequence similarities

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.

Contains 1 protein kinase domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform E Ref.2 (identifier: Q6DEH3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform G Ref.2 (identifier: Q6DEH3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     326-340: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 491491Calcium/calmodulin-dependent protein kinase type II delta 1 chain
PRO_0000296340

Regions

Domain13 – 271259Protein kinase
Nucleotide binding19 – 279ATP By similarity

Sites

Active site1351Proton acceptor By similarity
Binding site421ATP By similarity

Amino acid modifications

Modified residue2861Phosphothreonine By similarity UniProtKB Q6PHZ2
Modified residue3141Phosphoserine By similarity Ref.2
Modified residue3501Phosphothreonine By similarity UniProtKB Q6PHZ2

Natural variations

Alternative sequence326 – 34015Missing in isoform G. Ref.2
VSP_035558

Sequences

Sequence LengthMass (Da)Tools
Isoform E [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: ADCFD717E279AF15

FASTA49155,829
        10         20         30         40         50         60 
MASTTCTRFT DEYQLYEELG KGAFSVVRRC MKISTGQEYA AKIINTKKLS ARDHQKLERE 

        70         80         90        100        110        120 
ARICRLLKHA NIVRLHDSIS EEGVHYLVFD LVTGGELFED IVAREYYSEA DASHCIQQIL 

       130        140        150        160        170        180 
EAVLHCHQMG VVHRDLKPEN LLLASKLKGA AVKLADFGLA IEVQGDQQAW FGFAGTPGYL 

       190        200        210        220        230        240 
SPEVLRKEPY GKPVDMWACG VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV 

       250        260        270        280        290        300 
TPEAKDLINK MLTINPAKRI TAAEALKHPW ICQRSTVASM MHRQETVECL KKFNARRKLK 

       310        320        330        340        350        360 
GAILTTMLAT RNFSSKNPYK KPDGVKEPQT TVIHNPTDGN KESSESTNTT IEDEDIKARK 

       370        380        390        400        410        420 
QEIIKVTELL IEAINNGEFE AYTKICDPGL TSFEPEALGN LVEGTDFHRF YFENSLSKGH 

       430        440        450        460        470        480 
KPIHTILLNP HVHLIGEDAA CIAYIRLTQY MDVNNMPRTM QSEETRVWHR RDGKWQNIHF 

       490 
HRSGSPTVPT K

« Hide

Isoform G [UniParc].

Checksum: 7FE8293D631CD611
Show »

FASTA47654,196

References

« Hide 'large scale' references
[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS E AND G).
Tissue: Embryo and Olfactory epithelium.
[2]"Differential expression of CaMK-II genes during early zebrafish embryogenesis."
Rothschild S.C., Lister J.A., Tombes R.M.
Dev. Dyn. 236:295-305(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 301-383 (ISOFORMS E AND G), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC077143 mRNA. Translation: AAH77143.1.
BC154189 mRNA. Translation: AAI54190.1.
IPIIPI00485345.
IPI00855579.
RefSeqNP_001003602.1. NM_001003602.2.
NP_001108180.1. NM_001114708.2.
UniGeneDr.78101.

3D structure databases

HSSPHSSP built from PDB template 2BDW based on UniProtKB Q9NG91.
ProteinModelPortalQ6DEH3.
SMRQ6DEH3. Positions 10-308, 349-487.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000056466; ENSDARP00000056465; ENSDARG00000043010.
ENSDART00000142259; ENSDARP00000119349; ENSDARG00000043010.
GeneID445208.
KEGGdre:445208.

Organism-specific databases

CTD445208.
ZFINZDB-GENE-040801-121. camk2d1.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00680000099653.
HOGENOMHOG000233016.
HOVERGENHBG108055.
InParanoidQ6DEH3.
KOK04515.
OMASANTTME.
OrthoDBEOG42JNR7.

Gene expression databases

ArrayExpressQ6DEH3.
BgeeQ6DEH3.

Family and domain databases

InterProIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543. Ca/CaM-dep_prot_kinase-assoc.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERPTHR24347. PTHR24347. 1 hit.
PfamPF08332. CaMKII_AD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20831969.

Entry information

Entry nameKC2D1_DANRE
AccessionPrimary (citable) accession number: Q6DEH3
Secondary accession number(s): A8KBP0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 14, 2008
Last modified: April 3, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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