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Q6DEH3

- KC2D1_DANRE

UniProt

Q6DEH3 - KC2D1_DANRE

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Protein

Calcium/calmodulin-dependent protein kinase type II delta 1 chain

Gene
camk2d1, camk2db, zgc:101001, zgc:173815
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system By similarity.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei42 – 421ATP By similarity
Active sitei135 – 1351Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 279ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calmodulin-dependent protein kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type II delta 1 chain (EC:2.7.11.17)
Alternative name(s):
Calcium/calmodulin-dependent protein kinase type II delta-B chain
Short name:
CaM kinase II subunit delta-B
Short name:
CaM-kinase II delta-B chain
Short name:
CaMK-II subunit delta-B
Gene namesi
Name:camk2d1
Synonyms:camk2db
ORF Names:zgc:101001, zgc:173815
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-040801-121. camk2d1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Calcium/calmodulin-dependent protein kinase type II delta 1 chainPRO_0000296340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei286 – 2861Phosphothreonine By similarityBy similarity
Modified residuei314 – 3141Phosphoserine By similarity1 Publication
Modified residuei350 – 3501Phosphothreonine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6DEH3.

Expressioni

Tissue specificityi

First detected at the 18-somite stage where expression is restricted to somite boundaries. At 24 hpf, expression is elevated in epidermal tissue and in the hatching gland. After 24 hpf, expression dimishes, but persists at low levels along the dorsal trunk. At 48 hpf, expression is restricted at a low level to the forebrain. At 72 hpf, weak expression reappears along the entire dorsal trunk in discrete cell bodies.1 Publication

Gene expression databases

BgeeiQ6DEH3.

Interactioni

Subunit structurei

CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits By similarity.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6DEH3.
SMRiQ6DEH3. Positions 10-308, 349-487.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 271259Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00720000108643.
HOGENOMiHOG000233016.
HOVERGENiHBG108055.
InParanoidiQ6DEH3.
KOiK04515.
OMAiSSECKET.
OrthoDBiEOG7ZD1VM.
PhylomeDBiQ6DEH3.
TreeFamiTF315229.

Family and domain databases

InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543. Ca/CaM-dep_prot_kinase-assoc.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24347. PTHR24347. 1 hit.
PfamiPF08332. CaMKII_AD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform E1 Publication (identifier: Q6DEH3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASTTCTRFT DEYQLYEELG KGAFSVVRRC MKISTGQEYA AKIINTKKLS    50
ARDHQKLERE ARICRLLKHA NIVRLHDSIS EEGVHYLVFD LVTGGELFED 100
IVAREYYSEA DASHCIQQIL EAVLHCHQMG VVHRDLKPEN LLLASKLKGA 150
AVKLADFGLA IEVQGDQQAW FGFAGTPGYL SPEVLRKEPY GKPVDMWACG 200
VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV TPEAKDLINK 250
MLTINPAKRI TAAEALKHPW ICQRSTVASM MHRQETVECL KKFNARRKLK 300
GAILTTMLAT RNFSSKNPYK KPDGVKEPQT TVIHNPTDGN KESSESTNTT 350
IEDEDIKARK QEIIKVTELL IEAINNGEFE AYTKICDPGL TSFEPEALGN 400
LVEGTDFHRF YFENSLSKGH KPIHTILLNP HVHLIGEDAA CIAYIRLTQY 450
MDVNNMPRTM QSEETRVWHR RDGKWQNIHF HRSGSPTVPT K 491
Length:491
Mass (Da):55,829
Last modified:October 14, 2008 - v2
Checksum:iADCFD717E279AF15
GO
Isoform G1 Publication (identifier: Q6DEH3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     326-340: Missing.

Show »
Length:476
Mass (Da):54,196
Checksum:i7FE8293D631CD611
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei326 – 34015Missing in isoform G. 1 PublicationVSP_035558Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC077143 mRNA. Translation: AAH77143.1.
BC154189 mRNA. Translation: AAI54190.1.
RefSeqiNP_001003602.1. NM_001003602.2. [Q6DEH3-2]
NP_001108180.1. NM_001114708.2. [Q6DEH3-1]
UniGeneiDr.78101.

Genome annotation databases

EnsembliENSDART00000056466; ENSDARP00000056465; ENSDARG00000043010. [Q6DEH3-1]
ENSDART00000142259; ENSDARP00000119349; ENSDARG00000043010. [Q6DEH3-2]
GeneIDi445208.
KEGGidre:445208.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC077143 mRNA. Translation: AAH77143.1 .
BC154189 mRNA. Translation: AAI54190.1 .
RefSeqi NP_001003602.1. NM_001003602.2. [Q6DEH3-2 ]
NP_001108180.1. NM_001114708.2. [Q6DEH3-1 ]
UniGenei Dr.78101.

3D structure databases

ProteinModelPortali Q6DEH3.
SMRi Q6DEH3. Positions 10-308, 349-487.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6DEH3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000056466 ; ENSDARP00000056465 ; ENSDARG00000043010 . [Q6DEH3-1 ]
ENSDART00000142259 ; ENSDARP00000119349 ; ENSDARG00000043010 . [Q6DEH3-2 ]
GeneIDi 445208.
KEGGi dre:445208.

Organism-specific databases

CTDi 445208.
ZFINi ZDB-GENE-040801-121. camk2d1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00720000108643.
HOGENOMi HOG000233016.
HOVERGENi HBG108055.
InParanoidi Q6DEH3.
KOi K04515.
OMAi SSECKET.
OrthoDBi EOG7ZD1VM.
PhylomeDBi Q6DEH3.
TreeFami TF315229.

Miscellaneous databases

NextBioi 20831969.

Gene expression databases

Bgeei Q6DEH3.

Family and domain databases

InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543. Ca/CaM-dep_prot_kinase-assoc.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24347. PTHR24347. 1 hit.
Pfami PF08332. CaMKII_AD. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS E AND G).
    Tissue: Embryo and Olfactory epithelium.
  2. "Differential expression of CaMK-II genes during early zebrafish embryogenesis."
    Rothschild S.C., Lister J.A., Tombes R.M.
    Dev. Dyn. 236:295-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 301-383 (ISOFORMS E AND G), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

Entry informationi

Entry nameiKC2D1_DANRE
AccessioniPrimary (citable) accession number: Q6DEH3
Secondary accession number(s): A8KBP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 14, 2008
Last modified: May 14, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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