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Q6DEH3

- KC2D1_DANRE

UniProt

Q6DEH3 - KC2D1_DANRE

Protein

Calcium/calmodulin-dependent protein kinase type II delta 1 chain

Gene

camk2d1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.Curated

    Enzyme regulationi

    Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei42 – 421ATPPROSITE-ProRule annotation
    Active sitei135 – 1351Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 279ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calmodulin-dependent protein kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Calmodulin-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium/calmodulin-dependent protein kinase type II delta 1 chain1 Publication (EC:2.7.11.17)
    Alternative name(s):
    Calcium/calmodulin-dependent protein kinase type II delta-B chain
    Short name:
    CaM kinase II subunit delta-B
    Short name:
    CaM-kinase II delta-B chain
    Short name:
    CaMK-II subunit delta-B
    Gene namesi
    Name:camk2d11 Publication
    Synonyms:camk2dbImported
    ORF Names:zgc:101001, zgc:173815
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 7

    Organism-specific databases

    ZFINiZDB-GENE-040801-121. camk2d1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Calcium/calmodulin-dependent protein kinase type II delta 1 chainPRO_0000296340Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei286 – 2861PhosphothreonineBy similarity
    Modified residuei314 – 3141PhosphoserineBy similarity
    Modified residuei350 – 3501PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ6DEH3.

    Expressioni

    Tissue specificityi

    First detected at the 18-somite stage where expression is restricted to somite boundaries. At 24 hpf, expression is elevated in epidermal tissue and in the hatching gland. After 24 hpf, expression dimishes, but persists at low levels along the dorsal trunk. At 48 hpf, expression is restricted at a low level to the forebrain. At 72 hpf, weak expression reappears along the entire dorsal trunk in discrete cell bodies.1 Publication

    Gene expression databases

    BgeeiQ6DEH3.

    Interactioni

    Subunit structurei

    CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DEH3.
    SMRiQ6DEH3. Positions 10-308, 349-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 271259Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00720000108643.
    HOGENOMiHOG000233016.
    HOVERGENiHBG108055.
    InParanoidiQ6DEH3.
    KOiK04515.
    OMAiSSECKET.
    OrthoDBiEOG7ZD1VM.
    PhylomeDBiQ6DEH3.
    TreeFamiTF315229.

    Family and domain databases

    InterProiIPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR013543. Ca/CaM-dep_prot_kinase-assoc.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR24347. PTHR24347. 1 hit.
    PfamiPF08332. CaMKII_AD. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform E1 Publication (identifier: Q6DEH3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASTTCTRFT DEYQLYEELG KGAFSVVRRC MKISTGQEYA AKIINTKKLS    50
    ARDHQKLERE ARICRLLKHA NIVRLHDSIS EEGVHYLVFD LVTGGELFED 100
    IVAREYYSEA DASHCIQQIL EAVLHCHQMG VVHRDLKPEN LLLASKLKGA 150
    AVKLADFGLA IEVQGDQQAW FGFAGTPGYL SPEVLRKEPY GKPVDMWACG 200
    VILYILLVGY PPFWDEDQHR LYQQIKAGAY DFPSPEWDTV TPEAKDLINK 250
    MLTINPAKRI TAAEALKHPW ICQRSTVASM MHRQETVECL KKFNARRKLK 300
    GAILTTMLAT RNFSSKNPYK KPDGVKEPQT TVIHNPTDGN KESSESTNTT 350
    IEDEDIKARK QEIIKVTELL IEAINNGEFE AYTKICDPGL TSFEPEALGN 400
    LVEGTDFHRF YFENSLSKGH KPIHTILLNP HVHLIGEDAA CIAYIRLTQY 450
    MDVNNMPRTM QSEETRVWHR RDGKWQNIHF HRSGSPTVPT K 491
    Length:491
    Mass (Da):55,829
    Last modified:October 14, 2008 - v2
    Checksum:iADCFD717E279AF15
    GO
    Isoform G1 Publication (identifier: Q6DEH3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         326-340: Missing.

    Show »
    Length:476
    Mass (Da):54,196
    Checksum:i7FE8293D631CD611
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei326 – 34015Missing in isoform G. 2 PublicationsVSP_035558Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC077143 mRNA. Translation: AAH77143.1.
    BC154189 mRNA. Translation: AAI54190.1.
    RefSeqiNP_001003602.1. NM_001003602.2. [Q6DEH3-2]
    NP_001108180.1. NM_001114708.2. [Q6DEH3-1]
    UniGeneiDr.78101.

    Genome annotation databases

    EnsembliENSDART00000056466; ENSDARP00000056465; ENSDARG00000043010. [Q6DEH3-1]
    ENSDART00000142259; ENSDARP00000119349; ENSDARG00000043010. [Q6DEH3-2]
    GeneIDi445208.
    KEGGidre:445208.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC077143 mRNA. Translation: AAH77143.1 .
    BC154189 mRNA. Translation: AAI54190.1 .
    RefSeqi NP_001003602.1. NM_001003602.2. [Q6DEH3-2 ]
    NP_001108180.1. NM_001114708.2. [Q6DEH3-1 ]
    UniGenei Dr.78101.

    3D structure databases

    ProteinModelPortali Q6DEH3.
    SMRi Q6DEH3. Positions 10-308, 349-487.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6DEH3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000056466 ; ENSDARP00000056465 ; ENSDARG00000043010 . [Q6DEH3-1 ]
    ENSDART00000142259 ; ENSDARP00000119349 ; ENSDARG00000043010 . [Q6DEH3-2 ]
    GeneIDi 445208.
    KEGGi dre:445208.

    Organism-specific databases

    CTDi 445208.
    ZFINi ZDB-GENE-040801-121. camk2d1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00720000108643.
    HOGENOMi HOG000233016.
    HOVERGENi HBG108055.
    InParanoidi Q6DEH3.
    KOi K04515.
    OMAi SSECKET.
    OrthoDBi EOG7ZD1VM.
    PhylomeDBi Q6DEH3.
    TreeFami TF315229.

    Miscellaneous databases

    NextBioi 20831969.

    Gene expression databases

    Bgeei Q6DEH3.

    Family and domain databases

    InterProi IPR020636. Ca/CaM-dep_Ca-dep_prot_Kinase.
    IPR013543. Ca/CaM-dep_prot_kinase-assoc.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR24347. PTHR24347. 1 hit.
    Pfami PF08332. CaMKII_AD. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS E AND G).
      Tissue: EmbryoImported and Olfactory epitheliumImported.
    2. "Differential expression of CaMK-II genes during early zebrafish embryogenesis."
      Rothschild S.C., Lister J.A., Tombes R.M.
      Dev. Dyn. 236:295-305(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 301-383 (ISOFORMS E AND G), ALTERNATIVE SPLICING, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiKC2D1_DANRE
    AccessioniPrimary (citable) accession number: Q6DEH3
    Secondary accession number(s): A8KBP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3