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Protein

Transcription factor MafB

Gene

mafb

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator or repressor. Implicated in the regulation of cell-type specific gene expression and play a role in inductive events during lens development.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafB
Short name:
Maf-B
Short name:
XMafB
Gene namesi
Name:mafb
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6085884. mafb.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Transcription factor MafBPRO_0000366126Add
BLAST

Expressioni

Developmental stagei

Expressed in the anterior neuroectoderm at stage 14. Expressed during the formation of the neural tube in rhombomeres (r) 5 and 6, in the derivative neural crest cells and then in the dorsal half of neural tube of r5 and r6 at stage 24. Expressed in the presumptive blood islands at stages 22 and 24. By stage 28 its expression in r5 disappears, but becomes detectable in r4 at stages 29 and 30. Its expression in r6 persists until stages 33 and 34. Expressed through r4 in two bilaterally symmetrical columns of cells in the dorsolateral spinal cord at stage 32. Expressed in developing somites at stages 33 and 34. Expressed in myotomal cells at stage 32. Expressed in the pronephros at stage 28. Expressed in the presumptive lens-forming ectoderm (PLE) at stage 22 and during lens formation. Expressed in the inner (sensorial) layer of PLE, developing lens placode and lens epithelium. Expressed in the anterior part of lens vesicle at stages 32 to 34.1 Publication

Interactioni

Subunit structurei

Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or a heterodimer (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6DE84.
SMRiQ6DE84. Positions 198-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 28864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni225 – 25026Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni253 – 27422Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 18857His-richAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG000313.
KOiK09036.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR013592. Maf_TF_N.
IPR028571. MafB.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF10. PTHR10129:SF10. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
PF08383. Maf_N. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DE84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGELPIATP LPTSPLAMEY LNDFDLMKFD VKKEPLGGRP DRAIRQCNRL
60 70 80 90 100
QPTGSVSSTP ISTPCSSVPS SPSFSPTEHK THLDDLYWMS SSSYQHVSPE
110 120 130 140 150
ALNLTPEDAV EALIGQHQMP PQLQGYESFR AHHHHHHQNQ HQYQGVHHEE
160 170 180 190 200
MGLPHHHPHH HQHQHHQTSP SPSGSSSSSQ QLHHQQQHSS SSAVEDRFSD
210 220 230 240 250
DQLVSMTVRE LNRHLRGFTK DDVIRLKQKR RTLKNRGYAQ SCRYKRVQQK
260 270 280 290 300
HNLEGEKTQL VQQVEQLKQE VSRLARERDA YKIKCEKLAN NNSSNFREAG
310
STSDNPSSPE FFM
Length:313
Mass (Da):35,749
Last modified:August 16, 2004 - v1
Checksum:i7E637A071FFE64F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981F → L in AAF08316 (PubMed:11231068).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202058 mRNA. Translation: AAF08316.1.
BC077255 mRNA. Translation: AAH77255.1.
RefSeqiNP_001083852.1. NM_001090383.1.
UniGeneiXl.19807.

Genome annotation databases

GeneIDi399156.
KEGGixla:399156.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF202058 mRNA. Translation: AAF08316.1.
BC077255 mRNA. Translation: AAH77255.1.
RefSeqiNP_001083852.1. NM_001090383.1.
UniGeneiXl.19807.

3D structure databases

ProteinModelPortaliQ6DE84.
SMRiQ6DE84. Positions 198-238.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399156.
KEGGixla:399156.

Organism-specific databases

CTDi9935.
XenbaseiXB-GENE-6085884. mafb.

Phylogenomic databases

HOVERGENiHBG000313.
KOiK09036.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR013592. Maf_TF_N.
IPR028571. MafB.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PTHR10129:SF10. PTHR10129:SF10. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
PF08383. Maf_N. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Distinct roles of maf genes during Xenopus lens development."
    Ishibashi S., Yasuda K.
    Mech. Dev. 101:155-166(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    Tissue: Embryonic head.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiMAFB_XENLA
AccessioniPrimary (citable) accession number: Q6DE84
Secondary accession number(s): Q9PUA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: August 16, 2004
Last modified: October 14, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.