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Protein

Mitochondrial glycine transporter

Gene

slc25a38

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38UniRule annotation
Gene namesi
Name:slc25a38UniRule annotation
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 53Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei87 – 113Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei125 – 150Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei178 – 201Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei217 – 243Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei272 – 290Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918061 – 302Mitochondrial glycine transporterAdd BLAST302

Proteomic databases

PRIDEiQ6DE75

Structurei

3D structure databases

ProteinModelPortaliQ6DE75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 112Solcar 1UniRule annotationAdd BLAST91
Repeati119 – 203Solcar 2UniRule annotationAdd BLAST85
Repeati213 – 297Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG054682

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q6DE75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNALVVAGD SLVPSNRVSQ MHPVFKAFVC GSLSGTCSTL LFQPLDLVKT
60 70 80 90 100
RIQAHQLSAS AAGSRPRMLN LLIKVVRNEN ILGLWKGVSP SFLRCIPGVG
110 120 130 140 150
LYFSTLYTLK HHFFSERDPK PLESVMLGAG SRTVAAVCML PFTVVKTRYE
160 170 180 190 200
SGKYGYNSVY GALKAIYKTE GPRGLFSGLT ATLMRDAPFS GIYLMFYTRA
210 220 230 240 250
KKLAPHDQID PLFSPVLNFS CGIVAGILAS VATQPADVIK THMQLANEKY
260 270 280 290 300
HWTGKVALNI YRTQGLTGFF QGGVPRALRR TLMAAMAWTV YEQMMEKMGL

KS
Length:302
Mass (Da):33,172
Last modified:August 16, 2004 - v1
Checksum:iA4EFD9A10F1213D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077266 mRNA Translation: AAH77266.1

Similar proteinsi

Entry informationi

Entry nameiS2538_XENLA
AccessioniPrimary (citable) accession number: Q6DE75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: August 16, 2004
Last modified: April 25, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health