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Protein

Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase B

Gene

b3gnt5-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids.By similarity

Catalytic activityi

UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase B (EC:2.4.1.206)
Alternative name(s):
Lactotriaosylceramide synthase B
Short name:
Lc(3)Cer synthase B
Short name:
Lc3 synthase B
UDP-GlcNAc:beta-Gal beta-1,3-N-acetylglucosaminyltransferase 5B
Short name:
BGnT-5B
Short name:
Beta-1,3-Gn-T5B
Short name:
Beta-1,3-N-acetylglucosaminyltransferase 5B
Short name:
Beta3Gn-T5B
Gene namesi
Name:b3gnt5-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6255936. b3gnt5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3017Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini31 – 377347LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase BPRO_0000289216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis
Glycosylationi167 – 1671N-linked (GlcNAc...)Sequence analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6DE15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG101684.
KOiK03766.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DE15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLISARRLRR CQSLQLLASC FVLSLMALLV QEDNSLVNHV KSYSYRYLIN
60 70 80 90 100
SYNFVNDSLS VPRDRSDGAA GYRYLINNRH KCLNEDVLLL LFVKTAPENR
110 120 130 140 150
RRRNAIRKTW GNEDYIRSRY AANIKVVFAL GVERDPVKSH HTQQDLVNEN
160 170 180 190 200
KRFKDLIQQD FSDTFHNLTL KLLLQFGWVN SFCPSAKFIM SADDDIFVHT
210 220 230 240 250
PNLVTYLKSL PIETQDFWIG RVHRGSPPIR SKASKYYVPY EMYPWSSYPD
260 270 280 290 300
YTAGAAYVVS RDVAAKVYEA SQTLNTSLYI DDVFMGICAN KMGVVPQYHV
310 320 330 340 350
YFSGEGKSPY HPCIYNKMMT SHGHLGDLDY LWRQATDSNV KSLSSGFLGN
360 370
VYCKIVNIML LCKIGYVDTY PCSAAWS
Length:377
Mass (Da):43,295
Last modified:August 16, 2004 - v1
Checksum:iDC4D36670DFC049D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077332 mRNA. Translation: AAH77332.1.
RefSeqiNP_001086705.1. NM_001093236.1.
UniGeneiXl.70391.

Genome annotation databases

GeneIDi446540.
KEGGixla:446540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077332 mRNA. Translation: AAH77332.1.
RefSeqiNP_001086705.1. NM_001093236.1.
UniGeneiXl.70391.

3D structure databases

ProteinModelPortaliQ6DE15.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi446540.
KEGGixla:446540.

Organism-specific databases

CTDi446540.
XenbaseiXB-GENE-6255936. b3gnt5.

Phylogenomic databases

HOVERGENiHBG101684.
KOiK03766.

Enzyme and pathway databases

UniPathwayiUPA00378.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiB3G5B_XENLA
AccessioniPrimary (citable) accession number: Q6DE15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: August 16, 2004
Last modified: December 9, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.