Q6DDK5 (ILVBL_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetolactate synthase-like protein
EC=2.2.1.-

Alternative name(s):
IlvB-like protein

Gene names

Name:

ilvbl

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	649 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor	Binds 1 magnesium ion per subunit By similarity. Binds 1 thiamine pyrophosphate per subunit By similarity.
Subcellular location	Membrane; Single-pass membrane protein.
Sequence similarities	Belongs to the TPP enzyme family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Magnesium Metal-binding Thiamine pyrophosphate
Molecular function	Transferase
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 649	649	Acetolactate synthase-like protein		PRO_0000314828
Regions
	Transmembrane	2 – 21	20	Helical; Potential
	Region	474 – 554	81	Thiamine pyrophosphate binding By similarity
Sites
	Metal binding	525	1	Magnesium By similarity
	Metal binding	551	1	Magnesium By similarity
	Binding site	84	1	Thiamine pyrophosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6DDK5 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 4A369CF0FE3B1D1F	FASTA	649	71,429
	10 20 30 40 50 60 MFHLIPFVVA FLLVFLTWFL IKKLRKVIIF ELDQNSKHFG GELVADVLKA HDVRFLFTLC 70 80 90 100 110 120 GGHISPILVA AERQNIRVID VRHEASAVFA ADAVSRLSGT VGVAAVTAGP GLTNTVTAVK 130 140 150 160 170 180 NAQMAESPIV LLAGAAAGLL RGRGSLQDID QLSLFRPLCK WSGRVNCVKD IVPMLCKAFY 190 200 210 220 230 240 LARSGTPGPV LVEFPIDTLY PYSLVRQHLR ISDNPQSWRQ RFTNWYLRFY LFRLFANGFR 250 260 270 280 290 300 IQPCLPGQVP TQIPVEIPSI PWPSTKSIDQ LVWLLSQAKR PVIVVSSQAL LPPVPATQTA 310 320 330 340 350 360 EHVKSLRIPV YLTGMARGLL GRHHPCVFRH ARRAALRVAD LIILAGSVCD FRMDYGRVLN 370 380 390 400 410 420 RKAKIVIINR DKKQLYLNSD IFWRPYLAIR GDVGTALKEL SISLNDRFPC LSDFRCPTEW 430 440 450 460 470 480 VGELLAREHH RDEEIRQSSL TQPAERINPL SVLWQLEHNG LTDQESIIVA DGGDFVGSAA 490 500 510 520 530 540 YILRPRGPLS WLDPGPFGTL GVGGGFALGA KLCRPQAHVW VVYGDGSAGY SLAEWDTMAR 550 560 570 580 590 600 HKAPAIGVIG NDACWSQIAR DQLGLFGSNV ACGLQSTRYD LVGAAYAGAD PLNSTLSVED 610 620 630 640 SGAFLVTEKN LDNLSDYMAH ARELSDRGLP SIINCNIAAS GFREGSISL

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC077553 mRNA. Translation: AAH77553.1.
RefSeq	NP_001086850.1. NM_001093381.1.
UniGene	Xl.48381.
3D structure databases
HSSP	HSSP built from PDB template 1OZH based on UniProtKB P27696.
ProteinModelPortal	Q6DDK5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	446685.
KEGG	xla:446685.
Organism-specific databases
CTD	10994.
Xenbase	XB-GENE-6255656. ilvbl.
Phylogenomic databases
HOVERGEN	HBG108004.
Family and domain databases
InterPro	IPR012000. Thiamin_PyroP_enz_cen_dom. IPR012001. Thiamin_PyroP_enz_TPP-bd_dom. IPR000399. TPP-bd_CS. IPR011766. TPP_enzyme-bd_C. [Graphical view]
KO	K11259.
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF00205. TPP_enzyme_M. 1 hit. PF02776. TPP_enzyme_N. 1 hit. [Graphical view]
PROSITE	PS00187. TPP_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ILVBL_XENLA

Accession

Primary (citable) accession number: Q6DDK5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 16, 2004
Last modified:	November 16, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program