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Protein

Eukaryotic translation initiation factor 6

Gene

eif6

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factorUniRule annotationImported, IntegrinImported

Keywords - Biological processi

Protein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:eif6UniRule annotationImported
Synonyms:itgb4bpImported
ORF Names:TEgg004b07.1-001Imported, TNeu062l19.1-001Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-868337. eif6.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleusnucleolus UniRule annotation

  • Note: Shuttles between cytoplasm and nucleus/nucleolus.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSXETG00000026867.

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Protein-protein interaction databases

STRINGi8364.ENSXETP00000056385.

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
HOGENOMiHOG000230605.
HOVERGENiHBG001300.
KOiK03264.
OrthoDBiEOG091G0HYF.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DDC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRASFENN NEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSETIPVVH
60 70 80 90 100
ASIAGCRIIG RMCVGNRHGL MVPNNTTDQE LQHIRNSLPD SVRIQRVEER
110 120 130 140 150
LSALGNVIAC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TIADQVLVGS
160 170 180 190 200
YCAFSNQGGL LHPKTSIEDQ DELSSLLQVP LVTGTVNRGS EVIAAGMVVN
210 220 230 240
DWSAFCGLDT TSTELSVIES VFKLSDAHPS TIATSMRDSL IDSLT
Length:245
Mass (Da):26,606
Last modified:August 16, 2004 - v1
Checksum:i2600CC69C9DB4F3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077665 mRNA. Translation: AAH77665.1.
CR760524 mRNA. Translation: CAJ81759.1.
CR848359 mRNA. Translation: CAJ82882.1.
RefSeqiNP_001006884.1. NM_001006883.1.
UniGeneiStr.5852.

Genome annotation databases

GeneIDi448711.
KEGGixtr:448711.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077665 mRNA. Translation: AAH77665.1.
CR760524 mRNA. Translation: CAJ81759.1.
CR848359 mRNA. Translation: CAJ82882.1.
RefSeqiNP_001006884.1. NM_001006883.1.
UniGeneiStr.5852.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000056385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi448711.
KEGGixtr:448711.

Organism-specific databases

CTDi3692.
XenbaseiXB-GENE-868337. eif6.

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
HOGENOMiHOG000230605.
HOVERGENiHBG001300.
KOiK03264.
OrthoDBiEOG091G0HYF.

Gene expression databases

BgeeiENSXETG00000026867.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiIPR002769. eIF6.
[Graphical view]
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiPF01912. eIF-6. 1 hit.
[Graphical view]
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiSM00654. eIF6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00323. eIF-6. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6DDC3_XENTR
AccessioniPrimary (citable) accession number: Q6DDC3
Entry historyi
Integrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.