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Protein

Eukaryotic translation initiation factor 6

Gene

eif6

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factorUniRule annotationImported, IntegrinImported
Biological processProtein biosynthesis, Ribosome biogenesisUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 6UniRule annotation
Short name:
eIF-6UniRule annotation
Gene namesi
Name:eif6Imported
Synonyms:EIF6UniRule annotation, itgb4bpImported
ORF Names:TEgg004b07.1-001Imported, TNeu062l19.1-001Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-868337. eif6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

Interactioni

Subunit structurei

Monomer. Associates with the 60S ribosomal subunit.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the eIF-6 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3185. Eukaryota.
COG1976. LUCA.
HOGENOMiHOG000230605.
HOVERGENiHBG001300.
KOiK03264.
OrthoDBiEOG091G0HYF.

Family and domain databases

CDDicd00527. IF6. 1 hit.
HAMAPiMF_00032. eIF_6. 1 hit.
InterProiView protein in InterPro
IPR002769. eIF6.
PANTHERiPTHR10784. PTHR10784. 1 hit.
PfamiView protein in Pfam
PF01912. eIF-6. 1 hit.
PIRSFiPIRSF006413. IF-6. 1 hit.
SMARTiView protein in SMART
SM00654. eIF6. 1 hit.
TIGRFAMsiTIGR00323. eIF-6. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6DDC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVRASFENN NEIGCFAKLT NTYCLVAIGG SENFYSVFEG ELSETIPVVH
60 70 80 90 100
ASIAGCRIIG RMCVGNRHGL MVPNNTTDQE LQHIRNSLPD SVRIQRVEER
110 120 130 140 150
LSALGNVIAC NDYVALVHPD LDRETEEILA DVLKVEVFRQ TIADQVLVGS
160 170 180 190 200
YCAFSNQGGL LHPKTSIEDQ DELSSLLQVP LVTGTVNRGS EVIAAGMVVN
210 220 230 240
DWSAFCGLDT TSTELSVIES VFKLSDAHPS TIATSMRDSL IDSLT
Length:245
Mass (Da):26,606
Last modified:August 16, 2004 - v1
Checksum:i2600CC69C9DB4F3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077665 mRNA. Translation: AAH77665.1.
CR760524 mRNA. Translation: CAJ81759.1.
CR848359 mRNA. Translation: CAJ82882.1.
RefSeqiNP_001006884.1. NM_001006883.1.
UniGeneiStr.5852.

Genome annotation databases

GeneIDi448711.
KEGGixtr:448711.

Similar proteinsi

Entry informationi

Entry nameiQ6DDC3_XENTR
AccessioniPrimary (citable) accession number: Q6DDC3
Entry historyiIntegrated into UniProtKB/TrEMBL: August 16, 2004
Last sequence update: August 16, 2004
Last modified: September 27, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)