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Protein

Zinc finger protein 787

Gene

ZNF787

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri94 – 116C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri122 – 144C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 787
Alternative name(s):
TTF-I-interacting peptide 20
Gene namesi
Name:ZNF787
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142409.5
HGNCiHGNC:26998 ZNF787
neXtProtiNX_Q6DD87

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142409
PharmGKBiPA162410481

Polymorphism and mutation databases

BioMutaiZNF787
DMDMi527504074

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876061 – 381Zinc finger protein 787Add BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphothreonineCombined sources1
Modified residuei122PhosphotyrosineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6DD87
PaxDbiQ6DD87
PeptideAtlasiQ6DD87
PRIDEiQ6DD87

PTM databases

iPTMnetiQ6DD87
PhosphoSitePlusiQ6DD87

Expressioni

Gene expression databases

BgeeiENSG00000142409
CleanExiHS_ZNF787

Organism-specific databases

HPAiHPA035140

Interactioni

Protein-protein interaction databases

BioGridi125966, 11 interactors
STRINGi9606.ENSP00000270459

Structurei

3D structure databases

ProteinModelPortaliQ6DD87
SMRiQ6DD87
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 65Pro-richAdd BLAST28
Compositional biasi209 – 276Ala-richAdd BLAST68

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri94 – 116C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri122 – 144C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144128
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6DD87
OMAiAPKPYVC
OrthoDBiEOG091G0ANV
PhylomeDBiQ6DD87
TreeFamiTF337689

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequencei

Sequence statusi: Complete.

Q6DD87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELREEAWSP GPLDSEDQQM ASHENPVDIL IMDDDDVPSW PPTKLSPPQS
60 70 80 90 100
APPAGPPPRP RPPAPYICNE CGKSFSHWSK LTRHQRTHTG ERPNACADCG
110 120 130 140 150
KTFSQSSHLV QHRRIHTGEK PYACLECGKR FSWSSNLMQH QRIHTGEKPY
160 170 180 190 200
TCPDCGRSFT QSKSLAKHRR SHSGLKPFVC PRCGRGFSQP KSLARHLRLH
210 220 230 240 250
PELSGPGVAA KVLAASVRRA KGPEEAVAAD GEIAIPVGDG EGIIVVGAPG
260 270 280 290 300
EGAAAAAAMA GAGAKAAGPR SRRAPAPKPY VCLECGKGFG HGAGLLAHQR
310 320 330 340 350
AQHGDGLGAA GGEEPAHICV ECGEGFVQGA ALRRHKKIHA VGAPSVCSSC
360 370 380
GQSYYRAGGE EEDDDDEAAG GRCPECRGGE GR
Length:382
Mass (Da):40,428
Last modified:February 28, 2018 - v4
Checksum:iE34481D98570C2A5
GO

Sequence cautioni

The sequence AAB58413 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti363D → DD in AC024580 (PubMed:15057824).Curated1
Sequence conflicti378G → A in AAB58413 (Ref. 1) Curated1
Sequence conflicti378G → A in AAH77728 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032336379G → A. Corresponds to variant dbSNP:rs4077285Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000560 mRNA Translation: AAB58413.1 Different initiation.
AC024580 Genomic DNA No translation available.
KF573663 Genomic DNA No translation available.
BC077728 mRNA Translation: AAH77728.1
CCDSiCCDS42634.1
RefSeqiNP_001002836.2, NM_001002836.3
XP_011524747.1, XM_011526445.2
UniGeneiHs.397153

Genome annotation databases

EnsembliENST00000610935; ENSP00000478557; ENSG00000142409
GeneIDi126208
KEGGihsa:126208

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN787_HUMAN
AccessioniPrimary (citable) accession number: Q6DD87
Secondary accession number(s): A0A087WUD1, O00455
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: February 28, 2018
Last modified: May 23, 2018
This is version 126 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health