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Protein

Zinc finger protein 787

Gene

ZNF787

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri94 – 116C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri122 – 144C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 787
Alternative name(s):
TTF-I-interacting peptide 20
Gene namesi
Name:ZNF787
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:26998. ZNF787.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410481.

Polymorphism and mutation databases

BioMutaiZNF787.
DMDMi527504074.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876061 – 382Zinc finger protein 787Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphothreonineCombined sources1
Modified residuei122PhosphotyrosineCombined sources1
Modified residuei132PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6DD87.
MaxQBiQ6DD87.
PaxDbiQ6DD87.
PeptideAtlasiQ6DD87.
PRIDEiQ6DD87.

PTM databases

iPTMnetiQ6DD87.
PhosphoSitePlusiQ6DD87.

Expressioni

Gene expression databases

BgeeiENSG00000142409.
CleanExiHS_ZNF787.

Organism-specific databases

HPAiHPA035140.

Interactioni

Protein-protein interaction databases

BioGridi125966. 9 interactors.
STRINGi9606.ENSP00000270459.

Structurei

3D structure databases

ProteinModelPortaliQ6DD87.
SMRiQ6DD87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 65Pro-richAdd BLAST28
Compositional biasi209 – 276Ala-richAdd BLAST68

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri94 – 116C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri122 – 144C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6DD87.
PhylomeDBiQ6DD87.
TreeFamiTF337689.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DD87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELREEAWSP GPLDSEDQQM ASHENPVDIL IMDDDDVPSW PPTKLSPPQS
60 70 80 90 100
APPAGPPPRP RPPAPYICNE CGKSFSHWSK LTRHQRTHTG ERPNACADCG
110 120 130 140 150
KTFSQSSHLV QHRRIHTGEK PYACLECGKR FSWSSNLMQH QRIHTGEKPY
160 170 180 190 200
TCPDCGRSFT QSKSLAKHRR SHSGLKPFVC PRCGRGFSQP KSLARHLRLH
210 220 230 240 250
PELSGPGVAA KVLAASVRRA KGPEEAVAAD GEIAIPVGDG EGIIVVGAPG
260 270 280 290 300
EGAAAAAAMA GAGAKAAGPR SRRAPAPKPY VCLECGKGFG HGAGLLAHQR
310 320 330 340 350
AQHGDGLGAA GGEEPAHICV ECGEGFVQGA ALRRHKKIHA VGAPSVCSSC
360 370 380
GQSYYRAGGE EEDDDDDEAA GGRCPECRGG EGR
Length:383
Mass (Da):40,543
Last modified:July 24, 2013 - v3
Checksum:i7FE2CDE7B89E8472
GO

Sequence cautioni

The sequence AAB58413 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti363Missing in AAB58413 (Ref. 1) Curated1
Sequence conflicti363Missing in AAH77728 (PubMed:15489334).Curated1
Sequence conflicti379G → A in AAB58413 (Ref. 1) Curated1
Sequence conflicti379G → A in AAH77728 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032336380G → A.Corresponds to variant rs4077285dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000560 mRNA. Translation: AAB58413.1. Different initiation.
AC024580 Genomic DNA. No translation available.
BC077728 mRNA. Translation: AAH77728.1.
RefSeqiNP_001002836.2. NM_001002836.3.
UniGeneiHs.397153.

Genome annotation databases

EnsembliENST00000270459; ENSP00000270459; ENSG00000142409.
GeneIDi126208.
KEGGihsa:126208.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000560 mRNA. Translation: AAB58413.1. Different initiation.
AC024580 Genomic DNA. No translation available.
BC077728 mRNA. Translation: AAH77728.1.
RefSeqiNP_001002836.2. NM_001002836.3.
UniGeneiHs.397153.

3D structure databases

ProteinModelPortaliQ6DD87.
SMRiQ6DD87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125966. 9 interactors.
STRINGi9606.ENSP00000270459.

PTM databases

iPTMnetiQ6DD87.
PhosphoSitePlusiQ6DD87.

Polymorphism and mutation databases

BioMutaiZNF787.
DMDMi527504074.

Proteomic databases

EPDiQ6DD87.
MaxQBiQ6DD87.
PaxDbiQ6DD87.
PeptideAtlasiQ6DD87.
PRIDEiQ6DD87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270459; ENSP00000270459; ENSG00000142409.
GeneIDi126208.
KEGGihsa:126208.

Organism-specific databases

CTDi126208.
GeneCardsiZNF787.
HGNCiHGNC:26998. ZNF787.
HPAiHPA035140.
neXtProtiNX_Q6DD87.
PharmGKBiPA162410481.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6DD87.
PhylomeDBiQ6DD87.
TreeFamiTF337689.

Miscellaneous databases

ChiTaRSiZNF787. human.
GenomeRNAii126208.
PROiQ6DD87.

Gene expression databases

BgeeiENSG00000142409.
CleanExiHS_ZNF787.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 7 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN787_HUMAN
AccessioniPrimary (citable) accession number: Q6DD87
Secondary accession number(s): O00455
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 24, 2013
Last modified: November 2, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.