Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 787

Gene

ZNF787

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri94 – 116C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri122 – 144C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 787
Alternative name(s):
TTF-I-interacting peptide 20
Gene namesi
Name:ZNF787
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:26998. ZNF787.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410481.

Polymorphism and mutation databases

BioMutaiZNF787.
DMDMi527504074.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002876061 – 382Zinc finger protein 787Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphothreonineCombined sources1
Modified residuei122PhosphotyrosineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6DD87.
MaxQBiQ6DD87.
PaxDbiQ6DD87.
PeptideAtlasiQ6DD87.
PRIDEiQ6DD87.

PTM databases

iPTMnetiQ6DD87.
PhosphoSitePlusiQ6DD87.

Expressioni

Gene expression databases

CleanExiHS_ZNF787.

Organism-specific databases

HPAiHPA035140.

Interactioni

Protein-protein interaction databases

BioGridi125966. 10 interactors.
STRINGi9606.ENSP00000270459.

Structurei

3D structure databases

ProteinModelPortaliQ6DD87.
SMRiQ6DD87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 65Pro-richAdd BLAST28
Compositional biasi209 – 276Ala-richAdd BLAST68

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri66 – 88C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri94 – 116C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri122 – 144C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 172C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri178 – 200C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri317 – 339C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6DD87.
PhylomeDBiQ6DD87.
TreeFamiTF337689.

Family and domain databases

Gene3Di2.10.290.10. 1 hit.
InterProiView protein in InterPro
IPR029037. YfgJ-like.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF57667. SSF57667. 5 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequencei

Sequence statusi: Complete.

Q6DD87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELREEAWSP GPLDSEDQQM ASHENPVDIL IMDDDDVPSW PPTKLSPPQS
60 70 80 90 100
APPAGPPPRP RPPAPYICNE CGKSFSHWSK LTRHQRTHTG ERPNACADCG
110 120 130 140 150
KTFSQSSHLV QHRRIHTGEK PYACLECGKR FSWSSNLMQH QRIHTGEKPY
160 170 180 190 200
TCPDCGRSFT QSKSLAKHRR SHSGLKPFVC PRCGRGFSQP KSLARHLRLH
210 220 230 240 250
PELSGPGVAA KVLAASVRRA KGPEEAVAAD GEIAIPVGDG EGIIVVGAPG
260 270 280 290 300
EGAAAAAAMA GAGAKAAGPR SRRAPAPKPY VCLECGKGFG HGAGLLAHQR
310 320 330 340 350
AQHGDGLGAA GGEEPAHICV ECGEGFVQGA ALRRHKKIHA VGAPSVCSSC
360 370 380
GQSYYRAGGE EEDDDDDEAA GGRCPECRGG EGR
Length:383
Mass (Da):40,543
Last modified:July 24, 2013 - v3
Checksum:i7FE2CDE7B89E8472
GO

Sequence cautioni

The sequence AAB58413 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti363Missing in AAB58413 (Ref. 1) Curated1
Sequence conflicti363Missing in AAH77728 (PubMed:15489334).Curated1
Sequence conflicti379G → A in AAB58413 (Ref. 1) Curated1
Sequence conflicti379G → A in AAH77728 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032336380G → A. Corresponds to variant dbSNP:rs4077285Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000560 mRNA. Translation: AAB58413.1. Different initiation.
AC024580 Genomic DNA. No translation available.
BC077728 mRNA. Translation: AAH77728.1.
RefSeqiNP_001002836.2. NM_001002836.3.
UniGeneiHs.397153.

Genome annotation databases

EnsembliENST00000270459; ENSP00000270459; ENSG00000142409.
GeneIDi126208.
KEGGihsa:126208.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN787_HUMAN
AccessioniPrimary (citable) accession number: Q6DD87
Secondary accession number(s): O00455
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 24, 2013
Last modified: November 22, 2017
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families