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Protein

Zinc finger protein Gfi-1b

Gene

gfi1b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 19924C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri205 – 22723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 34024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Gfi-1b
Alternative name(s):
Growth factor independent protein 1B
Gene namesi
Name:gfi1b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-944429. gfi1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Zinc finger protein Gfi-1bPRO_0000306330Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6DCW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020Mediates repression of transcriptionBy similarityAdd
BLAST
Regioni1 – 2020SNAG domainBy similarityAdd
BLAST

Domaini

The zinc finger domain is essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain.By similarity

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 19924C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri205 – 22723C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri233 – 25523C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri261 – 28323C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri289 – 31123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri317 – 34024C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG106655.
KOiK09223.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR029840. GFI1/1B.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR19303:SF239. PTHR19303:SF239. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DCW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVKSK KTHTYNQHRY VEEQPVTGVD LVATVYHAHC TECPAEFPAF
60 70 80 90 100
STDPTEKQHT PENVITEEAR SDPGDPREKI PFLSRSISPN SFQGIALSSM
110 120 130 140 150
RPLKHYDPSP LSAFYTQNFS WDALHSTYGF KQIPSHIHPS MLQNSINLYS
160 170 180 190 200
CPPRVDSDSD HPINYSMSYS PKMDTYHCVK CSKVFSTSHG LEVHVRRSHS
210 220 230 240 250
GTRPFVCNIC GKSFGHAVSL EQHLNVHSQE RSFECKMCGK TFKRSSTLST
260 270 280 290 300
HLLIHSDTRP YPCQFCGKRF HQKSDMKKHT YIHTGEKPHK CQVCGKAFSQ
310 320 330 340
SSNLITHSRK HTGFKPFSCD LCCKGFQRKV DLRRHRENQH GLK
Length:343
Mass (Da):39,227
Last modified:August 16, 2004 - v1
Checksum:i77ACD7B606B79FD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077878 mRNA. Translation: AAH77878.1.
RefSeqiNP_001087000.1. NM_001093531.1.
UniGeneiXl.48425.

Genome annotation databases

GeneIDi446835.
KEGGixla:446835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077878 mRNA. Translation: AAH77878.1.
RefSeqiNP_001087000.1. NM_001093531.1.
UniGeneiXl.48425.

3D structure databases

ProteinModelPortaliQ6DCW1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi446835.
KEGGixla:446835.

Organism-specific databases

CTDi8328.
XenbaseiXB-GENE-944429. gfi1b.

Phylogenomic databases

HOVERGENiHBG106655.
KOiK09223.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR029840. GFI1/1B.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR19303:SF239. PTHR19303:SF239. 1 hit.
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGFI1B_XENLA
AccessioniPrimary (citable) accession number: Q6DCW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: August 16, 2004
Last modified: January 20, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.