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Protein

Zinc finger protein Gfi-1b

Gene

gfi1b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 199C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri205 – 227C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 340C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein Gfi-1b
Alternative name(s):
Growth factor independent protein 1B
Gene namesi
Name:gfi1b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-944429 gfi1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003063301 – 343Zinc finger protein Gfi-1bAdd BLAST343

Structurei

3D structure databases

ProteinModelPortaliQ6DCW1
SMRiQ6DCW1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 20Mediates repression of transcriptionBy similarityAdd BLAST20
Regioni1 – 20SNAG domainBy similarityAdd BLAST20

Domaini

The zinc finger domain is essential for erythroid expansion and acts as an activation domain whereas non finger domain serves as repression domain.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri176 – 199C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri205 – 227C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri233 – 255C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri261 – 283C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri289 – 311C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri317 – 340C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG106655
KOiK09223

Family and domain databases

InterProiView protein in InterPro
IPR037044 Gfi-1b
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR44643 PTHR44643, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequencei

Sequence statusi: Complete.

Q6DCW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRSFLVKSK KTHTYNQHRY VEEQPVTGVD LVATVYHAHC TECPAEFPAF
60 70 80 90 100
STDPTEKQHT PENVITEEAR SDPGDPREKI PFLSRSISPN SFQGIALSSM
110 120 130 140 150
RPLKHYDPSP LSAFYTQNFS WDALHSTYGF KQIPSHIHPS MLQNSINLYS
160 170 180 190 200
CPPRVDSDSD HPINYSMSYS PKMDTYHCVK CSKVFSTSHG LEVHVRRSHS
210 220 230 240 250
GTRPFVCNIC GKSFGHAVSL EQHLNVHSQE RSFECKMCGK TFKRSSTLST
260 270 280 290 300
HLLIHSDTRP YPCQFCGKRF HQKSDMKKHT YIHTGEKPHK CQVCGKAFSQ
310 320 330 340
SSNLITHSRK HTGFKPFSCD LCCKGFQRKV DLRRHRENQH GLK
Length:343
Mass (Da):39,227
Last modified:August 16, 2004 - v1
Checksum:i77ACD7B606B79FD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC077878 mRNA Translation: AAH77878.1
RefSeqiNP_001087000.1, NM_001093531.1
UniGeneiXl.48425

Genome annotation databases

GeneIDi446835
KEGGixla:446835

Similar proteinsi

Entry informationi

Entry nameiGFI1B_XENLA
AccessioniPrimary (citable) accession number: Q6DCW1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: August 16, 2004
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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