Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q6DCQ8 (P4K2B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 4-kinase type 2-beta
EC=2.7.1.67
Alternative name(s):
Phosphatidylinositol 4-kinase type II-beta
Gene names
Name:pi4k2b
ORF Names:TGas067g11.1
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length495 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) By similarity.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.

Subcellular location

Cytoplasm By similarity. Membrane By similarity.

Sequence similarities

Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.

Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function1-phosphatidylinositol 4-kinase activity

Inferred from electronic annotation. Source: EC

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 495495Phosphatidylinositol 4-kinase type 2-beta
PRO_0000285169

Regions

Domain139 – 450312PI3K/PI4K
Compositional bias88 – 914Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
Q6DCQ8 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 4BE57BC43D3F34E0

FASTA49556,349
        10         20         30         40         50         60 
MEQKQTTEPR DSPPLLVLLD PAAEQLEVSA PHTPLSPQPQ SARAAPGSAV RFFCDSAREE 

        70         80         90        100        110        120 
EAGEDEPLLK KPGPMSPRAV RKGRTRLSSS SDDRENMSSG HVENGEYNVI LNDPEFADII 

       130        140        150        160        170        180 
HRAEQAIESG VFPERISQGS SGSYFVKDPK GKIIGVFKPK SEEPYGHLNP KWTKYFHKIC 

       190        200        210        220        230        240 
CPCCFGRGCL VPNQGYLSEA GAYLVDEKLG LGVVPKTKAV WLVSETFNYS AIDRAKSRGK 

       250        260        270        280        290        300 
KYALEKVPKV GKKFHRIGLP PKVGSFQLFV DGYKEADYWL RKFETDPLPE NTRKQLQSPF 

       310        320        330        340        350        360 
EKLVILDYVI RNTDRGNDNW LIRYDSQDDD ELSEKGDSFP LKDWKEIKEP IIKIAAIDNG 

       370        380        390        400        410        420 
LAFPFKHPDE WRAYPFHWAW LPQAKVPFSQ ETRDLILPRI SDMNFIQDLC EDLYELFKTD 

       430        440        450        460        470        480 
KGFDKDTFEK QMSVMRGQIL NLTQALKDGK TPIQLVQMPR VVVERSYSGS QGRIVQMSNA 

       490 
FTQTFHCRKP FFSSW

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC077943 mRNA. Translation: AAH77943.1.
RefSeqNP_001087050.1. NM_001093581.1.
UniGeneXl.77779.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID446885.
KEGGxla:446885.

Organism-specific databases

CTD55300.
XenbaseXB-GENE-974298. pi4k2b.

Phylogenomic databases

HOVERGENHBG059542.

Family and domain databases

InterProIPR000403. PI3/4_kinase_cat.
[Graphical view]
KOK13711.
PfamPF00454. PI3_PI4_kinase. 1 hit.
[Graphical view]
PROSITEPS00915. PI3_4_KINASE_1. False negative.
PS00916. PI3_4_KINASE_2. False negative.
PS50290. PI3_4_KINASE_3. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameP4K2B_XENLA
AccessionPrimary (citable) accession number: Q6DCQ8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: August 16, 2004
Last modified: November 16, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents