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Q6DCK3 (GRP2B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
RAS guanyl-releasing protein 2-B
Gene names
Name:rasgrp2-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May function in cell aggregation and adhesion By similarity.

Subcellular location

Cytoplasm › cytosol By similarity. Cell membrane; Peripheral membrane protein By similarity. Cell junction › synapse › synaptosome By similarity. Note: Found both in the cytosol and associated with membranes By similarity.

Sequence similarities

Belongs to the RASGRP family.

Contains 2 EF-hand domains.

Contains 1 N-terminal Ras-GEF domain.

Contains 1 phorbol-ester/DAG-type zinc finger.

Contains 1 Ras-GEF domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594RAS guanyl-releasing protein 2-B
PRO_0000315612

Regions

Domain3 – 121119N-terminal Ras-GEF
Domain149 – 382234Ras-GEF
Domain418 – 45336EF-hand 1
Domain447 – 48236EF-hand 2
Calcium binding431 – 442121 Potential
Calcium binding460 – 471122 Potential
Zinc finger490 – 54051Phorbol-ester/DAG-type

Sequences

Sequence LengthMass (Da)Tools
Q6DCK3 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 8B6CC286623B8EBB

FASTA59468,338
        10         20         30         40         50         60 
MDSSDLDKGL TIDEIIAKCI QSFDKDGKLS DPKLVQMFLM MHPWYIPSGD LAKKLFALSE 

        70         80         90        100        110        120 
SGDNVERERI CQFVRFWISE FPAEFDLNPE LGEQIRDLKR ALENKGNRRE SSLIDIESVP 

       130        140        150        160        170        180 
SYGWKRQVTQ RGPGGGRVRK TSLLFDHLDP AELAEHLTHL EFHSFSKILF QDYHSFVLHG 

       190        200        210        220        230        240 
CTVGNPVLER FIALFNGVSQ WIQLMVLSKH TPQQRAAVIK QFVQVAERLL QMQNFNTLMS 

       250        260        270        280        290        300 
VVGGLSHSSI SRLKDTQSHI SPETTKVYDS LLELLTSSDN YARYRRRFAT CKGFRFPALG 

       310        320        330        340        350        360 
VHLKDLMALH VALPDWADKA KTIINISKMR QVYKVVHELT EAQRLEPPVK ANPDLLNLLT 

       370        380        390        400        410        420 
VSLDQYRSEE EIYQLSLQRE PRARSTQTHA KSPPSPSPPL EEWASLKAKP DQALLCQHIE 

       430        440        450        460        470        480 
KMVESVFRLF DEDGDGHISQ EEFQSVRSNF PYLCAFNEID QNQDGKISKQ EMTSYFLRAS 

       490        500        510        520        530        540 
SVLDCKMGFI HNFAERTFLR PVSCQHCRNL ILGIYKKGLK CKACGITCHK HCRDHLSIEC 

       550        560        570        580        590 
KKRSKSVSER GESMEKGRHF FFTLPRSFRR STLYPDLREE EPHMEDDGVF DDHL

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC078012 mRNA. Translation: AAH78012.1.
RefSeqNP_001087119.1. NM_001093650.1.
UniGeneXl.14799.

3D structure databases

HSSPHSSP built from PDB template 1Y8F based on UniProtKB Q62768.
ProteinModelPortalQ6DCK3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID447008.
KEGGxla:447008.

Organism-specific databases

CTD447008.
XenbaseXB-GENE-986629. rasgrp2.

Phylogenomic databases

HOVERGENHBG007513.
KOK12361.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
1.10.840.10. 1 hit.
InterProIPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR008937. Ras_GEF.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PANTHERPTHR23113. PTHR23113. 1 hit.
PfamPF00130. C1_1. 1 hit.
PF13202. EF_hand_3. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTSM00109. C1. 1 hit.
SM00054. EFh. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMSSF48366. Ras_GEF. 1 hit.
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00720. RASGEF. False negative.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGRP2B_XENLA
AccessionPrimary (citable) accession number: Q6DCK3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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