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Q6DCK3

- GRP2B_XENLA

UniProt

Q6DCK3 - GRP2B_XENLA

Protein

RAS guanyl-releasing protein 2-B

Gene

rasgrp2-b

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May function in cell aggregation and adhesion By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi431 – 442121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi460 – 471122PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri490 – 54051Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of small GTPase mediated signal transduction Source: InterPro
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Ligandi

    Calcium, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RAS guanyl-releasing protein 2-B
    Gene namesi
    Name:rasgrp2-b
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-986629. rasgrp2.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Cell junctionsynapsesynaptosome By similarity
    Note: Found both in the cytosol and associated with membranes.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cytosol Source: UniProtKB-SubCell
    3. neuron projection Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell
    5. synapse Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Membrane, Synapse, Synaptosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 594594RAS guanyl-releasing protein 2-BPRO_0000315612Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DCK3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 121119N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini149 – 382234Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini418 – 45336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini447 – 48236EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RASGRP family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 phorbol-ester/DAG-type zinc finger.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri490 – 54051Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    HOVERGENiHBG007513.
    KOiK12361.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    1.10.840.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view]
    PfamiPF00130. C1_1. 1 hit.
    PF13202. EF-hand_5. 2 hits.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 1 hit.
    SM00054. EFh. 2 hits.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DCK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSSDLDKGL TIDEIIAKCI QSFDKDGKLS DPKLVQMFLM MHPWYIPSGD    50
    LAKKLFALSE SGDNVERERI CQFVRFWISE FPAEFDLNPE LGEQIRDLKR 100
    ALENKGNRRE SSLIDIESVP SYGWKRQVTQ RGPGGGRVRK TSLLFDHLDP 150
    AELAEHLTHL EFHSFSKILF QDYHSFVLHG CTVGNPVLER FIALFNGVSQ 200
    WIQLMVLSKH TPQQRAAVIK QFVQVAERLL QMQNFNTLMS VVGGLSHSSI 250
    SRLKDTQSHI SPETTKVYDS LLELLTSSDN YARYRRRFAT CKGFRFPALG 300
    VHLKDLMALH VALPDWADKA KTIINISKMR QVYKVVHELT EAQRLEPPVK 350
    ANPDLLNLLT VSLDQYRSEE EIYQLSLQRE PRARSTQTHA KSPPSPSPPL 400
    EEWASLKAKP DQALLCQHIE KMVESVFRLF DEDGDGHISQ EEFQSVRSNF 450
    PYLCAFNEID QNQDGKISKQ EMTSYFLRAS SVLDCKMGFI HNFAERTFLR 500
    PVSCQHCRNL ILGIYKKGLK CKACGITCHK HCRDHLSIEC KKRSKSVSER 550
    GESMEKGRHF FFTLPRSFRR STLYPDLREE EPHMEDDGVF DDHL 594
    Length:594
    Mass (Da):68,338
    Last modified:August 16, 2004 - v1
    Checksum:i8B6CC286623B8EBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078012 mRNA. Translation: AAH78012.1.
    RefSeqiNP_001087119.1. NM_001093650.1.
    UniGeneiXl.14799.

    Genome annotation databases

    GeneIDi447008.
    KEGGixla:447008.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078012 mRNA. Translation: AAH78012.1 .
    RefSeqi NP_001087119.1. NM_001093650.1.
    UniGenei Xl.14799.

    3D structure databases

    ProteinModelPortali Q6DCK3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 447008.
    KEGGi xla:447008.

    Organism-specific databases

    CTDi 447008.
    Xenbasei XB-GENE-986629. rasgrp2.

    Phylogenomic databases

    HOVERGENi HBG007513.
    KOi K12361.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    1.10.840.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    [Graphical view ]
    Pfami PF00130. C1_1. 1 hit.
    PF13202. EF-hand_5. 2 hits.
    PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 1 hit.
    SM00054. EFh. 2 hits.
    SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS00479. ZF_DAG_PE_1. 1 hit.
    PS50081. ZF_DAG_PE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiGRP2B_XENLA
    AccessioniPrimary (citable) accession number: Q6DCK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3