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Q6DCK3

- GRP2B_XENLA

UniProt

Q6DCK3 - GRP2B_XENLA

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Protein
RAS guanyl-releasing protein 2-B
Gene
rasgrp2-b
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May function in cell aggregation and adhesion By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi431 – 442121 Reviewed prediction
Add
BLAST
Calcium bindingi460 – 471122 Reviewed prediction
Add
BLAST
Zinc fingeri490 – 54051Phorbol-ester/DAG-type
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BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. regulation of small GTPase mediated signal transduction Source: InterPro
  2. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RAS guanyl-releasing protein 2-B
Gene namesi
Name:rasgrp2-b
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-986629. rasgrp2.

Subcellular locationi

Cytoplasmcytosol By similarity. Cell membrane; Peripheral membrane protein By similarity. Cell junctionsynapsesynaptosome By similarity
Note: Found both in the cytosol and associated with membranes By similarity.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cytosol Source: UniProtKB-SubCell
  3. neuron projection Source: UniProtKB-SubCell
  4. plasma membrane Source: UniProtKB-SubCell
  5. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594RAS guanyl-releasing protein 2-B
PRO_0000315612Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6DCK3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 121119N-terminal Ras-GEF
Add
BLAST
Domaini149 – 382234Ras-GEF
Add
BLAST
Domaini418 – 45336EF-hand 1
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BLAST
Domaini447 – 48236EF-hand 2
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BLAST

Sequence similaritiesi

Belongs to the RASGRP family.
Contains 2 EF-hand domains.
Contains 1 Ras-GEF domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG007513.
KOiK12361.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
1.10.840.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view]
PfamiPF00130. C1_1. 1 hit.
PF13202. EF-hand_5. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00054. EFh. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DCK3-1 [UniParc]FASTAAdd to Basket

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MDSSDLDKGL TIDEIIAKCI QSFDKDGKLS DPKLVQMFLM MHPWYIPSGD    50
LAKKLFALSE SGDNVERERI CQFVRFWISE FPAEFDLNPE LGEQIRDLKR 100
ALENKGNRRE SSLIDIESVP SYGWKRQVTQ RGPGGGRVRK TSLLFDHLDP 150
AELAEHLTHL EFHSFSKILF QDYHSFVLHG CTVGNPVLER FIALFNGVSQ 200
WIQLMVLSKH TPQQRAAVIK QFVQVAERLL QMQNFNTLMS VVGGLSHSSI 250
SRLKDTQSHI SPETTKVYDS LLELLTSSDN YARYRRRFAT CKGFRFPALG 300
VHLKDLMALH VALPDWADKA KTIINISKMR QVYKVVHELT EAQRLEPPVK 350
ANPDLLNLLT VSLDQYRSEE EIYQLSLQRE PRARSTQTHA KSPPSPSPPL 400
EEWASLKAKP DQALLCQHIE KMVESVFRLF DEDGDGHISQ EEFQSVRSNF 450
PYLCAFNEID QNQDGKISKQ EMTSYFLRAS SVLDCKMGFI HNFAERTFLR 500
PVSCQHCRNL ILGIYKKGLK CKACGITCHK HCRDHLSIEC KKRSKSVSER 550
GESMEKGRHF FFTLPRSFRR STLYPDLREE EPHMEDDGVF DDHL 594
Length:594
Mass (Da):68,338
Last modified:August 16, 2004 - v1
Checksum:i8B6CC286623B8EBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078012 mRNA. Translation: AAH78012.1.
RefSeqiNP_001087119.1. NM_001093650.1.
UniGeneiXl.14799.

Genome annotation databases

GeneIDi447008.
KEGGixla:447008.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078012 mRNA. Translation: AAH78012.1 .
RefSeqi NP_001087119.1. NM_001093650.1.
UniGenei Xl.14799.

3D structure databases

ProteinModelPortali Q6DCK3.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 447008.
KEGGi xla:447008.

Organism-specific databases

CTDi 447008.
Xenbasei XB-GENE-986629. rasgrp2.

Phylogenomic databases

HOVERGENi HBG007513.
KOi K12361.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
1.10.840.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
[Graphical view ]
Pfami PF00130. C1_1. 1 hit.
PF13202. EF-hand_5. 2 hits.
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 1 hit.
SM00054. EFh. 2 hits.
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
PROSITEi PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiGRP2B_XENLA
AccessioniPrimary (citable) accession number: Q6DCK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 16, 2004
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi