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Q6DCJ1 (UB22B_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 22-B

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 22-B
Ubiquitin thioesterase 22-B
Ubiquitin-specific-processing protease 22-B
Gene names
Name:usp22-b
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators, where it is required for transcription By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of some SAGA transcription coactivator-HAT complexes By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the peptidase C19 family. UBP8 subfamily.

Contains 1 UBP-type zinc finger.

Contains 1 USP domain.

Sequence caution

The sequence AAH78033.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523Ubiquitin carboxyl-terminal hydrolase 22-B
PRO_0000367513

Regions

Domain174 – 518345USP
Zinc finger44 – 10461UBP-type

Sites

Active site1831Nucleophile By similarity
Active site4771Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6DCJ1 [UniParc].

Last modified March 24, 2009. Version 2.
Checksum: C0DE1CA8DD61439D

FASTA52360,109
        10         20         30         40         50         60 
MSPAGCSHVN SFKVENWRQN LRVIYQCFVW SGTPETRKRK AKSCVCHMCG AHLNRLHSCL 

        70         80         90        100        110        120 
YCVYFGCFTK KHIHEHAKNK RHNLAIDLLY GGIYCFMCQD YIYDKDMEQV AKEEQRKAWK 

       130        140        150        160        170        180 
LQVFSPALVS PYQYTMTGVG EKYSTWEPTK RELELLQHNP KRRKITTNCT IGLRGLINLG 

       190        200        210        220        230        240 
NTCFMNCIVQ ALTHTPLLRD FFLSDRHKCE MQSPNSCLVC EMSTLFQEFY SGHRSPHIPY 

       250        260        270        280        290        300 
RLLHLVWTHA RHLAGYEQQD AHEFLIAALD VLHRHCKGDD NGKKANNPNH CNCIIDQIFT 

       310        320        330        340        350        360 
GGLQSDVTCQ VCHGVSTTID PFWDISLDLP GSSTPFWPLS PGSDAGVVNG ESHVSGTTTL 

       370        380        390        400        410        420 
TDCLRRFTRP EHLGSSAKIK CSGCHSYQES TKQLTMKKLP IVACFHLKRF EHSAKLRRKI 

       430        440        450        460        470        480 
TTYVSFPLEL DMMPFMASSK ESRMNGQYQQ PSDSLHNDNK YSLFAVVNHQ GTLESGHYTS 

       490        500        510        520 
FIRQHKDQWF KCDDAIITKA SIKDVIDSEG YLLFYHKQFL EYE 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC078033 mRNA. Translation: AAH78033.1. Different initiation.
RefSeqNP_001090240.1. NM_001096771.1.
UniGeneXl.72110.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.035.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID779144.
KEGGxla:779144.

Organism-specific databases

CTD779144.
XenbaseXB-GENE-6086104. usp22.

Phylogenomic databases

HOVERGENHBG058014.
KOK11366.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUB22B_XENLA
AccessionPrimary (citable) accession number: Q6DCJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: March 24, 2009
Last modified: April 16, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries