Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bcl-2-related ovarian killer protein homolog A

Gene

boka

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in apoptosis. Does not appear to show pro-apoptotic activity when expressed ectopically in early embryos.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-related ovarian killer protein homolog A
Short name:
zBok1
Gene namesi
Name:bokaImported
Synonyms:bokImported
ORF Names:zgc:100979
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040801-131. boka.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass membrane protein By similarity
  • Golgi apparatus membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Bcl-2-related ovarian killer protein homolog APRO_0000283818Add
BLAST

Proteomic databases

PaxDbiQ6DC66.

Expressioni

Tissue specificityi

Strongest expression in ovary and eye, weaker expression in gut, kidney and brain. Little expression in liver or heart.1 Publication

Developmental stagei

Not expressed maternally. Zygotic expression from 24-72 hours post-fertilization (hpf). Also expressed in adult.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000123964.

Structurei

3D structure databases

ProteinModelPortaliQ6DC66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 4413BH4Sequence analysisAdd
BLAST
Motifi64 – 8017BH3Sequence analysisAdd
BLAST
Motifi110 – 14031BH1Sequence analysisAdd
BLAST
Motifi173 – 18715BH2Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOGENOMiHOG000290675.
HOVERGENiHBG050709.
InParanoidiQ6DC66.
PhylomeDBiQ6DC66.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
IPR026309. BOK.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF48. PTHR11256:SF48. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DC66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLRRSSVF AAEVMEVFDR SPTDKELVSQ SKVLCRDYIH SRLHRAGIGW
60 70 80 90 100
SKPEHGSGGT LAEVSSVLLW LGDELEYLRP NVYRNVARQL NITIASENIV
110 120 130 140 150
SDAFLAVAAE IFSTEYSRKG LEKHKGVTWG KIVSLYAVAG ALAVDCVRNG
160 170 180 190 200
HPAMVHTIVD CMGEFVRKSL ASWLKKRGGW ADITKCVVST DPSFHSHWLV
210 220
TAACACGHYL KAVVFYLLRE K
Length:221
Mass (Da):24,599
Last modified:August 16, 2004 - v1
Checksum:i1C60961C159C33AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078217 mRNA. Translation: AAH78217.1.
UniGeneiDr.34035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078217 mRNA. Translation: AAH78217.1.
UniGeneiDr.34035.

3D structure databases

ProteinModelPortaliQ6DC66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000123964.

Proteomic databases

PaxDbiQ6DC66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-040801-131. boka.

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOGENOMiHOG000290675.
HOVERGENiHBG050709.
InParanoidiQ6DC66.
PhylomeDBiQ6DC66.

Miscellaneous databases

NextBioi20831980.
PROiQ6DC66.

Family and domain databases

InterProiIPR002475. Bcl2-like.
IPR026298. Blc2_fam.
IPR026309. BOK.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF48. PTHR11256:SF48. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.
  2. "Functional characterization of the Bcl-2 gene family in the zebrafish."
    Kratz E., Eimon P.M., Mukhyala K., Stern H., Zha J., Strasser A., Hart R., Ashkenazi A.
    Cell Death Differ. 13:1631-1640(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiBOKA_DANRE
AccessioniPrimary (citable) accession number: Q6DC66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: August 16, 2004
Last modified: May 11, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.