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Protein

Bcl-2-related ovarian killer protein homolog A

Gene

boka

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in apoptosis. Does not appear to show pro-apoptotic activity when expressed ectopically in early embryos.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-related ovarian killer protein homolog ACurated
Short name:
zBok1
Gene namesi
Name:bokaImported
Synonyms:bokImported
ORF Names:zgc:100979
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040801-131 boka

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002838181 – 221Bcl-2-related ovarian killer protein homolog AAdd BLAST221

Proteomic databases

PaxDbiQ6DC66

Expressioni

Tissue specificityi

Strongest expression in ovary and eye, weaker expression in gut, kidney and brain. Little expression in liver or heart.1 Publication

Developmental stagei

Not expressed maternally. Zygotic expression from 24-72 hours post-fertilization (hpf). Also expressed in adult.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000123964

Structurei

3D structure databases

ProteinModelPortaliQ6DC66
SMRiQ6DC66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 44BH4Sequence analysisAdd BLAST13
Motifi64 – 80BH3Sequence analysisAdd BLAST17
Motifi110 – 140BH1Sequence analysisAdd BLAST31
Motifi173 – 187BH2Sequence analysisAdd BLAST15

Sequence similaritiesi

Belongs to the Bcl-2 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4728 Eukaryota
ENOG41123S0 LUCA
HOGENOMiHOG000290675
HOVERGENiHBG050709
InParanoidiQ6DC66
PhylomeDBiQ6DC66

Family and domain databases

Gene3Di1.10.437.10, 1 hit
InterProiView protein in InterPro
IPR002475 Bcl2-like
IPR036834 Blc2-like_sf
IPR026298 Blc2_fam
IPR026309 BOK
PANTHERiPTHR11256 PTHR11256, 1 hit
PTHR11256:SF48 PTHR11256:SF48, 1 hit
PfamiView protein in Pfam
PF00452 Bcl-2, 1 hit
SUPFAMiSSF56854 SSF56854, 1 hit
PROSITEiView protein in PROSITE
PS50062 BCL2_FAMILY, 1 hit

Sequencei

Sequence statusi: Complete.

Q6DC66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLRRSSVF AAEVMEVFDR SPTDKELVSQ SKVLCRDYIH SRLHRAGIGW
60 70 80 90 100
SKPEHGSGGT LAEVSSVLLW LGDELEYLRP NVYRNVARQL NITIASENIV
110 120 130 140 150
SDAFLAVAAE IFSTEYSRKG LEKHKGVTWG KIVSLYAVAG ALAVDCVRNG
160 170 180 190 200
HPAMVHTIVD CMGEFVRKSL ASWLKKRGGW ADITKCVVST DPSFHSHWLV
210 220
TAACACGHYL KAVVFYLLRE K
Length:221
Mass (Da):24,599
Last modified:August 16, 2004 - v1
Checksum:i1C60961C159C33AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC078217 mRNA Translation: AAH78217.1
UniGeneiDr.34035

Similar proteinsi

Entry informationi

Entry nameiBOKA_DANRE
AccessioniPrimary (citable) accession number: Q6DC66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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