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Q6DC37

- HNMT_DANRE

UniProt

Q6DC37 - HNMT_DANRE

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Protein
Histamine N-methyltransferase
Gene
hnmt, zgc:100917
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281Substrate By similarity
Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei89 – 891S-adenosyl-L-methionine By similarity
Binding sitei142 – 1421S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei283 – 2831Substrate By similarity

GO - Molecular functioni

  1. histamine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histamine N-methyltransferase (EC:2.1.1.8)
    Short name:
    HMT
    Gene namesi
    Name:hnmt
    ORF Names:zgc:100917
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040801-157. hnmt.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Histamine N-methyltransferase
    PRO_0000271424Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer By similarity.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DC37.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG39680.
    HOVERGENiHBG051914.
    InParanoidiQ6DC37.
    KOiK00546.
    PhylomeDBiQ6DC37.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PIRSFiPIRSF016616. HHMT. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51597. SAM_HNMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DC37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPFKTLVE DYPRYLKSFE LFLERSSEHQ CMQDFIHNTL PDILASIGGG    50
    RSVFNVMGVG SGAGDIDLEM LAQLHLKHPH VKVDNEVVEP SNDMLYKYKA 100
    RVSTSPDLAY INFTWNKMTA SEFEKQWQEK TPEKKMDFIH MIQMLYYVKD 150
    PNATVSFFRS LLEKDGKLLI ILVSGESGWG KLWTTFRKQL CYTEMSQCVT 200
    IGEIKSFLDS EGVPYRKYVL LSQMDITECF TEGDQEGELL LDFLTEVKEF 250
    SKNAPERLKK EVLDVLRHPD CSKEVDGRII FNNNLEVLVI EP 292
    Length:292
    Mass (Da):33,619
    Last modified:August 16, 2004 - v1
    Checksum:iE95CBB203B845FBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078250 mRNA. Translation: AAH78250.1.
    RefSeqiNP_001003636.1. NM_001003636.1.
    UniGeneiDr.17340.

    Genome annotation databases

    GeneIDi445242.
    KEGGidre:445242.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC078250 mRNA. Translation: AAH78250.1 .
    RefSeqi NP_001003636.1. NM_001003636.1.
    UniGenei Dr.17340.

    3D structure databases

    ProteinModelPortali Q6DC37.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 445242.
    KEGGi dre:445242.

    Organism-specific databases

    CTDi 3176.
    ZFINi ZDB-GENE-040801-157. hnmt.

    Phylogenomic databases

    eggNOGi NOG39680.
    HOVERGENi HBG051914.
    InParanoidi Q6DC37.
    KOi K00546.
    PhylomeDBi Q6DC37.

    Miscellaneous databases

    NextBioi 20832004.
    PROi Q6DC37.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PIRSFi PIRSF016616. HHMT. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51597. SAM_HNMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiHNMT_DANRE
    AccessioniPrimary (citable) accession number: Q6DC37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: August 16, 2004
    Last modified: June 11, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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