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Q6DC37

- HNMT_DANRE

UniProt

Q6DC37 - HNMT_DANRE

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Protein

Histamine N-methyltransferase

Gene

hnmt

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281SubstratePROSITE-ProRule annotation
Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
Binding sitei142 – 1421S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
Binding sitei283 – 2831SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. histamine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine N-methyltransferase (EC:2.1.1.8)
Short name:
HMT
Gene namesi
Name:hnmt
ORF Names:zgc:100917
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040801-157. hnmt.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Histamine N-methyltransferasePRO_0000271424Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6DC37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG39680.
HOVERGENiHBG051914.
InParanoidiQ6DC37.
KOiK00546.
PhylomeDBiQ6DC37.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PIRSFiPIRSF016616. HHMT. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51597. SAM_HNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DC37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPFKTLVE DYPRYLKSFE LFLERSSEHQ CMQDFIHNTL PDILASIGGG
60 70 80 90 100
RSVFNVMGVG SGAGDIDLEM LAQLHLKHPH VKVDNEVVEP SNDMLYKYKA
110 120 130 140 150
RVSTSPDLAY INFTWNKMTA SEFEKQWQEK TPEKKMDFIH MIQMLYYVKD
160 170 180 190 200
PNATVSFFRS LLEKDGKLLI ILVSGESGWG KLWTTFRKQL CYTEMSQCVT
210 220 230 240 250
IGEIKSFLDS EGVPYRKYVL LSQMDITECF TEGDQEGELL LDFLTEVKEF
260 270 280 290
SKNAPERLKK EVLDVLRHPD CSKEVDGRII FNNNLEVLVI EP
Length:292
Mass (Da):33,619
Last modified:August 16, 2004 - v1
Checksum:iE95CBB203B845FBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078250 mRNA. Translation: AAH78250.1.
RefSeqiNP_001003636.1. NM_001003636.1.
UniGeneiDr.17340.

Genome annotation databases

GeneIDi445242.
KEGGidre:445242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC078250 mRNA. Translation: AAH78250.1 .
RefSeqi NP_001003636.1. NM_001003636.1.
UniGenei Dr.17340.

3D structure databases

ProteinModelPortali Q6DC37.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 445242.
KEGGi dre:445242.

Organism-specific databases

CTDi 3176.
ZFINi ZDB-GENE-040801-157. hnmt.

Phylogenomic databases

eggNOGi NOG39680.
HOVERGENi HBG051914.
InParanoidi Q6DC37.
KOi K00546.
PhylomeDBi Q6DC37.

Miscellaneous databases

NextBioi 20832004.
PROi Q6DC37.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PIRSFi PIRSF016616. HHMT. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51597. SAM_HNMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiHNMT_DANRE
AccessioniPrimary (citable) accession number: Q6DC37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: August 16, 2004
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3