Q6DBU5 (GMPPB_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannose-1-phosphate guanyltransferase beta
EC=2.7.7.13

Alternative name(s):
GDP-mannose pyrophosphorylase B
GTP-mannose-1-phosphate guanylyltransferase beta

Gene names

Name:	gmppb
ORF Names:	zgc:92026

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Mannose-1-phosphate guanyltransferase beta		PRO_0000307165

Sequences

	Sequence		Length	Mass (Da)
	Q6DBU5 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 213D4CF3BA957615	FASTA	360	40,144
	10 20 30 40 50 60 MKALILVGGY GTRLRPLTLT VPKPLVEFCN KPILLHQVEA LVKAGVRHVI LAVSYMSELL 70 80 90 100 110 120 EREMRAQEQR LGIKISLSHE KEPLGTAGPL ALARELLTDN QEPFFVLNSD VICDFPFDDM 130 140 150 160 170 180 LKFHQQHGRE GTIVVTKVEE PSKYGVVVYE GDSGRIHRFV EKPQVFVSNK INAGMYIFSP 190 200 210 220 230 240 AMLRRIQLRP TSIEKEIFPV MAEEGQLYAM ELQGFWMDIG QPKDFLTGMC MYLQSVRQQA 250 260 270 280 290 300 PERLRAGPGF LGNVLVDPTA VIGQNCTIGP NVTIGAGVVL EDGVRVKRCT ILKGAHIRSH 310 320 330 340 350 360 SWLESCIVGW SSSVGQWVRM ENVTVLGEDV IVNDELYING ANVLPHKSIT DSVPEPRIIM

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC078357 mRNA. Translation: AAH78357.1.
IPI	IPI00505038.
RefSeq	NP_001003491.1. NM_001003491.1.
UniGene	Dr.105356.
3D structure databases
HSSP	HSSP built from PDB template 1WVC based on UniProtKB P26396.
ProteinModelPortal	Q6DBU5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6DBU5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	445097.
KEGG	dre:445097.
NMPDR	fig|7955.3.peg.14904.
Organism-specific databases
CTD	29925.
ZFIN	ZDB-GENE-040801-234. gmppb.
Phylogenomic databases
eggNOG	fiNOG05137.
GeneTree	ENSGT00530000063581.
HOVERGEN	HBG107955.
InParanoid	Q6DBU5.
PhylomeDB	Q6DBU5.
Gene expression databases
Bgee	Q6DBU5.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
KO	K00966.
Pfam	PF00132. Hexapep. 1 hit. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPPB_DANRE

Accession

Primary (citable) accession number: Q6DBU5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	August 16, 2004
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program