Reviewed, UniProtKB/Swiss-Prot Q6DB14 (MTLD_ERWCT)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	ECA0088

Organism

Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

29471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011798
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6DB14-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: D07474B129F4C0EE	FASTA	382	41,479
	10 20 30 40 50 60 MKALHFGAGN IGRGFIGKLL ADANVELTFA DVNQPLLDAL NSRKSYSVRI VGDNTQVEAV 70 80 90 100 110 120 SNVSAVHSGS QDAIALIAAA DLVTTAVGPQ ILEKIAGTIA QGLVKRHEDG NTRPLNIIAC 130 140 150 160 170 180 ENMVRGTSQL KQHVLKLLPE AHQEWVVEHV GFVDSAVDRI VPPSEAGSDD VLAVTVETFS 190 200 210 220 230 240 EWIVDKTQFC GEPPAIPGME LTDNLMAFVE RKLFTLNTGH AITAYLGQQA RHQTIRDAIL 250 260 270 280 290 300 DPKVRAVVKG AMEESGAVLI KRYGFDADKH AAYINKILSR FENPHLHDDV DRVGRQPLRK 310 320 330 340 350 360 LSAGDRLIKP LLGTLEYHLP HDNLIIGIAA AMHYRSEQDP QALELAELIR TLGPQATLVQ 370 380 ISGLDADSEV VAQAVNVYNA MQ

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed: 15263089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX950851 Genomic DNA. Translation: CAG73008.1.
RefSeq	YP_048216.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2881213.
GenomeReviews	Gene locus ECA0088 in contig BX950851_GR.
KEGG	eca:ECA0088.
NMPDR	fig|218491.3.peg.3050.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6DB14.
OMA	Q6DB14. VDRIVPN.
Enzyme and pathway databases
BioCyc	ECAR218491:ECA0088-MON.
BRENDA	1.1.1.17. 281579.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_ERWCT

Accession

Primary (citable) accession number: Q6DB14

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	August 16, 2004
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)