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Q6DAZ8

- ASSY_PECAS

UniProt

Q6DAZ8 - ASSY_PECAS

Protein

Argininosuccinate synthase

Gene

argG

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431ATPUniRule annotation
    Binding sitei99 – 991CitrullineUniRule annotation
    Binding sitei129 – 1291ATP; via amide nitrogenUniRule annotation
    Binding sitei131 – 1311AspartateUniRule annotation
    Binding sitei131 – 1311ATPUniRule annotation
    Binding sitei135 – 1351AspartateUniRule annotation
    Binding sitei135 – 1351CitrullineUniRule annotation
    Binding sitei136 – 1361AspartateUniRule annotation
    Binding sitei136 – 1361ATPUniRule annotation
    Binding sitei139 – 1391CitrullineUniRule annotation
    Binding sitei192 – 1921CitrullineUniRule annotation
    Binding sitei194 – 1941ATPUniRule annotation
    Binding sitei201 – 2011CitrullineUniRule annotation
    Binding sitei203 – 2031CitrullineUniRule annotation
    Binding sitei280 – 2801CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 259ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPATR218491:GJNB-106-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:ECA0104
    OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
    Taxonomic identifieri218491 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
    ProteomesiUP000007966: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448Argininosuccinate synthasePRO_1000025424Add
    BLAST

    Proteomic databases

    PRIDEiQ6DAZ8.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi218491.ECA0104.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6DAZ8.
    SMRiQ6DAZ8. Positions 2-445.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230094.
    KOiK01940.
    OMAiRQEMSEF.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00581. Arg_succ_synth_type2.
    InterProiIPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6DAZ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTILKHLPV GQRIGIAFSG GLDTSAALLW MRQKGAVPYA YTANLGQPDE    50
    DDYDEIPRRA MEYGAENARL IDCRKQLVAE GIAAIQCGAF HNTTAGVTYF 100
    NTTPLGRAVT GTMLVAAMKE DGVNIWGDGS TYKGNDIERF YRYGLLTNAE 150
    LKIYKPWLDT DFIDELGGRQ EMSEFMSQAG FGYKMSAEKA YSTDSNILGA 200
    THEAKDLEFL NSSVKIVNPI MGVKFWDENV KVPAEEVTIR FERGHPVALN 250
    GKTFTDDIEL MLEANRIGGR HGLGMSDQIE NRIIEAKSRG IYEAPGMALL 300
    HIAYERLLTG IHNEDTIEQY HANGRQLGRF LYQGRWFDSQ ALMLRDSSQR 350
    WIASAITGEV TLELRRGNDY SIMNTVSDNL TYKPERLTME KGDSVFSPDD 400
    RIGQLTMRNL DITDTREKLF NYAETGLLSS SASTGLPQVG QLQDKTEK 448
    Length:448
    Mass (Da):50,040
    Last modified:August 16, 2004 - v1
    Checksum:iA8A1EA763F11001F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950851 Genomic DNA. Translation: CAG73024.1.
    RefSeqiYP_048232.1. NC_004547.2.

    Genome annotation databases

    EnsemblBacteriaiCAG73024; CAG73024; ECA0104.
    GeneIDi2884142.
    KEGGieca:ECA0104.
    PATRICi20475357. VBIPecAtr54885_0106.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950851 Genomic DNA. Translation: CAG73024.1 .
    RefSeqi YP_048232.1. NC_004547.2.

    3D structure databases

    ProteinModelPortali Q6DAZ8.
    SMRi Q6DAZ8. Positions 2-445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218491.ECA0104.

    Proteomic databases

    PRIDEi Q6DAZ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG73024 ; CAG73024 ; ECA0104 .
    GeneIDi 2884142.
    KEGGi eca:ECA0104.
    PATRICi 20475357. VBIPecAtr54885_0106.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230094.
    KOi K01940.
    OMAi RQEMSEF.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci PATR218491:GJNB-106-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.400. 1 hit.
    3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00581. Arg_succ_synth_type2.
    InterProi IPR023437. Arg_succ_synth_type2_subfam.
    IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR024074. AS_cat/multimer_dom_body.
    IPR024073. AS_multimer_C_tail.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCRI 1043 / ATCC BAA-672.

    Entry informationi

    Entry nameiASSY_PECAS
    AccessioniPrimary (citable) accession number: Q6DAZ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3