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Protein

Acetylornithine deacetylase

Gene

argE

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Zn2+UniRule annotation, Co2+UniRule annotationNote: Binds 2 Zn2+ or Co2+ ions per subunit.UniRule annotation
  • glutathioneUniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetylornithine deacetylase (argE)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-ornithine from N(2)-acetyl-L-ornithine (linear), the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Cobalt or zinc 1UniRule annotation1
Active sitei82UniRule annotation1
Metal bindingi112Cobalt or zinc 1UniRule annotation1
Metal bindingi112Cobalt or zinc 2UniRule annotation1
Active sitei144UniRule annotation1
Metal bindingi145Cobalt or zinc 2UniRule annotation1
Metal bindingi169Cobalt or zinc 1UniRule annotation1
Metal bindingi355Cobalt or zinc 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

Cobalt, Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110.

Protein family/group databases

MEROPSiM20.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylaseUniRule annotation (EC:3.5.1.16UniRule annotation)
Short name:
AOUniRule annotation
Short name:
AcetylornithinaseUniRule annotation
Alternative name(s):
N-acetylornithinaseUniRule annotation
Short name:
NAOUniRule annotation
Gene namesi
Name:argEUniRule annotation
Ordered Locus Names:ECA0191
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaePectobacterium
Proteomesi
  • UP000007966 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000650581 – 383Acetylornithine deacetylaseAdd BLAST383

Proteomic databases

PRIDEiQ6DAR2.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi218491.ECA0191.

Structurei

3D structure databases

ProteinModelPortaliQ6DAR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CWC. Bacteria.
COG0624. LUCA.
HOGENOMiHOG000243769.
KOiK01438.
OMAiGTEAPYL.
OrthoDBiPOG091H0GAZ.

Family and domain databases

CDDicd03894. M20_ArgE. 1 hit.
Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE. 1 hit.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6DAR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMNLPPFIE LYRALIATPS ISATDSALDQ SNHTLINLLA GWFGDIGFHV
60 70 80 90 100
EVQPVPGTLN KFNMLARIGE GKGGLLLAGH TDTVPFDDGR WTRDPFTLTE
110 120 130 140 150
HDNKLYGLGT ADMKGFFAFI LDALRDIDPT KLTKPLYVLA TADEETTMAG
160 170 180 190 200
AKYFSESTQI RPDCAIIGEP TSLQPVRAHK GHMSNAIRIQ GQSGHSSDPS
210 220 230 240 250
RGVNAIELMH EAISHLLVLR NTLQERYHNP IFHIPYPTMN LGHIHGGDAA
260 270 280 290 300
NRICGCCELH MDIRPLPGIT LNDLDGLLSE ALAPVSQRWP GRLTISELHP
310 320 330 340 350
PIPGYECPPD HRLISVVENL LGTKTEIVNY CTEAPFIQTL CPTLVLGPGS
360 370 380
IEQAHQPDEY IDTAFIKPTR ELISQVIHHF CHH
Length:383
Mass (Da):42,269
Last modified:August 16, 2004 - v1
Checksum:i009560D126157E0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG73110.1.

Genome annotation databases

EnsemblBacteriaiCAG73110; CAG73110; ECA0191.
KEGGieca:ECA0191.
PATRICi20475525. VBIPecAtr54885_0190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG73110.1.

3D structure databases

ProteinModelPortaliQ6DAR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218491.ECA0191.

Protein family/group databases

MEROPSiM20.974.

Proteomic databases

PRIDEiQ6DAR2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAG73110; CAG73110; ECA0191.
KEGGieca:ECA0191.
PATRICi20475525. VBIPecAtr54885_0190.

Phylogenomic databases

eggNOGiENOG4105CWC. Bacteria.
COG0624. LUCA.
HOGENOMiHOG000243769.
KOiK01438.
OMAiGTEAPYL.
OrthoDBiPOG091H0GAZ.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110.

Family and domain databases

CDDicd03894. M20_ArgE. 1 hit.
Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE. 1 hit.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGE_PECAS
AccessioniPrimary (citable) accession number: Q6DAR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 16, 2004
Last modified: November 2, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.