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Reviewed, UniProtKB/Swiss-Prot Q6D9J6 (DSBD_ERWCT)

Last modified June 16, 2009. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Thiol:disulfide interchange protein dsbD
    EC=1.8.1.8
Alternative name(s):
    Protein-disulfide reductase
      Short name=Disulfide reductase
Gene names
Name: dsbD
Ordered Locus Names: ECA0618
OrganismErwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]
Taxonomic identifier29471 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

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Protein attributes

Sequence length577 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps By similarity.

Catalytic activity

Protein dithiol + NAD(P)+ = protein disulfide + NAD(P)H. HAMAP MF_00399

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the thioredoxin family. DsbD subfamily.

Contains 1 thioredoxin domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 577554Thiol:disulfide interchange protein dsbD HAMAP MF_00399
PRO_0000304385

Regions

Transmembrane182 – 20221 Potential
Transmembrane225 – 24521 Potential
Transmembrane255 – 27521 Potential
Transmembrane308 – 32821 Potential
Transmembrane338 – 35821 Potential
Transmembrane369 – 38921 Potential
Transmembrane396 – 41621 Potential
Domain437 – 577141Thioredoxin

Amino acid modifications

Disulfide bond131 ↔ 137Redox-active By similarity
Disulfide bond194 ↔ 316Redox-active By similarity
Disulfide bond492 ↔ 495Redox-active By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q6D9J6-1 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: 28B54B667E4016C0

FASTA57762,917
        10         20         30         40         50         60 
MAQRIFTLIF LLWTAVGTPQ VAASSFGQKL FGNSTTSRFL PVDGAFAFEF QQQGNQLNLR 

        70         80         90        100        110        120 
WDIHPDYYLY RAQIKIEGNG ATLGKVELPQ GESHNDEFFG QVFILRDRLA LAVPIEQAES 

       130        140        150        160        170        180 
GATVKVTYQG CADAGFCYPP ETRTVPLSQV LATANTDSPI NTLSGQTAPP QTTPMPFSPW 

       190        200        210        220        230        240 
WALLIGIGVA FTPCVLPMYP LIASLVLGRK EQLTPRRTLL LSMTYVQGMA LTYTLLGLIV 

       250        260        270        280        290        300 
AAAGLRFQAA LQHPYILIGL SVMFIALALS MFGLYTLQLP SSVQTRLTEW SNRQQGGSVT 

       310        320        330        340        350        360 
GVFCMGALAG LICSPCTTAP LSAILLYIAQ SGNMLAGGGT LYLYALGMGL PLILVTLFGN 

       370        380        390        400        410        420 
KLLPRSGPWM QYVKEAFGFI ILALPVFLLE RILGEAWGIR LWSALGIAFF GWALMLTLSS 

       430        440        450        460        470        480 
KKGWMRGVQL LLLAGVVISA KPLQDWVFPP TGTAQTHTSA LNFAPVANIA DLNSALAKSP 

       490        500        510        520        530        540 
QPVMLDLYAD WCVACKEFEK YTFSDPAVQN HLSRITLLQA DVTANREEQN ALLKKLQVLG 

       550        560        570 
LPTIVFFDTQ GKEIPGSRVT GFMNAEQFQA HLQKFSP

« Hide

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Cross-references

Sequence databases

BX950851 Genomic DNA. Translation: CAG73534.1.
RefSeqYP_048735.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID2882295.
GenomeReviewsGene locus ECA0618 in contig BX950851_GR.
KEGGeca:ECA0618.
NMPDRfig|218491.3.peg.2966.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ6D9J6.
OMAQ6D9J6. TITHILW.

Enzyme and pathway databases

BioCycECAR218491:ECA0618-MON.
BRENDA1.8.1.8. 281579.

Family and domain databases

HAMAPMF_00399.
[Tree]
InterProIPR003834. Cyt_c_assmbl_TM.
IPR017936. Thioredoxin-like.
IPR015467. Thioredoxin_core.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHERPTHR10438. Trx. 1 hit.
PfamPF02683. DsbD. 1 hit.
PF00085. Thioredoxin. 1 hit.
[Graphical view]
PROSITEPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDSBD_ERWCT
AccessionPrimary (citable) accession number: Q6D9J6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: August 16, 2004
Last modified: June 16, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents