Reviewed, UniProtKB/Swiss-Prot Q6D9G9 (UXAB_ERWCT)

Names and origin

Protein names

Recommended name:
    Altronate oxidoreductase
    EC=1.1.1.58
Alternative name(s):
    Tagaturonate reductase
    Tagaturonate dehydrogenase

Gene names

Name:	uxaB
Ordered Locus Names:	ECA0646

Organism

Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

29471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP MF_00670
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00670
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	Altronate oxidoreductase HAMAP MF_00670		PRO_0000170744
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6D9G9-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 14C477128322D778	FASTA	488	55,557
	10 20 30 40 50 60 MQTLNRRNFP GRQHPDRVIQ FGEGNFLRAF VDWQLDLLNE HTDLDAGIVI VRPIDSDFPP 70 80 90 100 110 120 ALDTQDGLYT TIIRGLNEQG EAVREPRLIR SVNREINVYR QFDEYLALAH DPNIRFVFSN 130 140 150 160 170 180 TTEAGISYHA DDRLSDAPPV SFPAKLTRLL YERFCHFDGA ADKGWVLLPC ELIDYNGVAL 190 200 210 220 230 240 KELVLRYAAQ WELTSTFTAW LNDHNTFCST LVDRIVTGYP RAEVEALQQE MGYQDTFWDT 250 260 270 280 290 300 AEHFYLFVIQ GPLWLAEELR LNKLDLNVRI VDDIKPYKER KVAILNGAHT ALVPVAFLAG 310 320 330 340 350 360 LDTVGESMND ALIGKFVEKT IAEEIVPVLD LPHDELTSFA QAVLSRFRNP FIQHQLLSIS 370 380 390 400 410 420 LNGMTKFRTR ILPQLLTYRE RHGELPARLT FALAALIAFY RGERSGEGDA LQAYPLQDDA 430 440 450 460 470 480 HWLERYSTLW AGVKENTVSL AELVNVVLRD ADHWEQDLTQ VPGLAAQVTE QLQTIVERGM RAAVEGYC

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed: 15263089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX950851 Genomic DNA. Translation: CAG73561.1.
RefSeq	YP_048762.1.
3D structure databases
SMR	Q6D9G9. Positions 4-487.
ModBase	Search...
Genome annotation databases
GeneID	2882732.
GenomeReviews	Gene locus ECA0646 in contig BX950851_GR.
KEGG	eca:ECA0646.
NMPDR	fig|218491.3.peg.2993.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG297101.
OMA	SIFPCEL.
Enzyme and pathway databases
BioCyc	ECAR218491:ECA0646-MONOMER.
BRENDA	1.1.1.58. 281579.
Family and domain databases
HAMAP	MF_00670. Altron_oxidoreduct. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UXAB_ERWCT

Accession

Primary (citable) accession number: Q6D9G9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	August 16, 2004
Last modified:	January 19, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)