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Q6D991 (TYPH_PECAS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:ECA0728
OrganismPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) [Complete proteome] [HAMAP]
Taxonomic identifier218491 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_0000059053

Sequences

Sequence LengthMass (Da)Tools
Q6D991 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: B9D62DAECE3E39C3

FASTA44247,216
        10         20         30         40         50         60 
MFLIQEIIRK KRDGKTLSEE EIRFFINGIR DNTVSEGQIA ALAMTIYFHD MSMDERVALT 

        70         80         90        100        110        120 
LAMRDSGTVL NWKSLNLNGP LVDKHSTGGV GDVTSLMLGP MVAACGGYVP MISGRGLGHT 

       130        140        150        160        170        180 
GGTLDKLEAI PGLDIFPNDD HFRRIIQQVG VAIIGQTSSL APADKRFYAT RDITATVDSI 

       190        200        210        220        230        240 
PLITASILAK KLAEGLDALV MDVKVGSGAF MPTYELSEQL AQAIVGVANN AGCRTSALLT 

       250        260        270        280        290        300 
DMNQVLASSA GNALEVREAV RFLTGESRNP RLYDVTMALC GEMLLAGGLA SSADDAHSRL 

       310        320        330        340        350        360 
QAVLDNGKAA DVFGRMVAAQ RGPGDFVEHY DRYLPVATLS KPVFATREGV VTAMDTRALG 

       370        380        390        400        410        420 
MAVVSLGGGR RQASDTIDYS VGLDSMISLG ERVDAQRPLA VIHANTEAQW QQAANEVRAA 

       430        440 
IQLGDTAPEK TPMVYRRVSA EA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950851 Genomic DNA. Translation: CAG73642.1.
RefSeqYP_048840.1. NC_004547.2.

3D structure databases

ProteinModelPortalQ6D991.
SMRQ6D991. Positions 1-439.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218491.ECA0728.

Proteomic databases

PRIDEQ6D991.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG73642; CAG73642; ECA0728.
GeneID2883783.
KEGGeca:ECA0728.
PATRIC20476636. VBIPecAtr54885_0726.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMADVWRRMI.
OrthoDBEOG61ZTGG.
ProtClustDBPRK05820.

Enzyme and pathway databases

BioCycPATR218491:GJNB-749-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_PECAS
AccessionPrimary (citable) accession number: Q6D991
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: August 16, 2004
Last modified: April 16, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways