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Q6D974

- GCSP_PECAS

UniProt

Q6D974 - GCSP_PECAS

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (16 Aug 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPATR218491:GJNB-769-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:ECA0745
    OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
    Taxonomic identifieri218491 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
    ProteomesiUP000007966: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 957957Glycine dehydrogenase (decarboxylating)PRO_0000227104Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi218491.ECA0745.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6D974.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6D974-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQTLSQLEH DGAFIERHIG PSVSQQQHML SVVGATSLDA LIRQIVPADI    50
    QLPSPPAVGE AVTEHEALAE LKAIAGRNQR YKSYIGMGYS AVLMPPVILR 100
    NVLENPGWYT AYTPYQPEVS QGRLEALLNF QQVTQDLTGL DLASASLLDE 150
    ATAAAEAMAM AKRISKLKQA ERFFVADDVH PQTLDVVRTR AETFGFEIVV 200
    GKAEEALKDD AVFGVLLQQA GTTGELHDYS DLMAALKARK VVSCVASDIM 250
    ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFACR DEHKRAMPGR 300
    IIGVSRDAAG NTAFRMAMQT REQHIRREKA NSNICTSQVL LANIAGMYAV 350
    FHGPEGLKRI AGRIHRLTDI LAAGLTQGGL LLRHRSWFDT LTIEVADKDV 400
    VLSRALSFGI NLRSDLASAV GITLDEATTR EDVLALFAVL LGDDHGLDIE 450
    ALDASIAQEV ATIPAGLLRH DAILSHPVFN RYHSETEMMR YLHRLARKDL 500
    ALNQAMIPLG SCTMKLNAAA EMLPITWPEF AELHPFCPPE QALGYRQMIE 550
    QLSGWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRRYHESR NEAGRHLCLI 600
    PSSAHGTNPA SAQMAGMEVV VVACDKQGNI DLHDLREKAQ AAGEQLSCIM 650
    VTYPSTHGVY EETIREVCQI VHQYGGQVYL DGANMNAQVG ITTPGYIGAD 700
    VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHQVV KIDGVLTEQG 750
    AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQMAILNAN YIATRLQQAY 800
    PVLYTGRDGR VAHECILDIR PLKESTGISE MDIAKRLIDY GFHAPTMSFP 850
    VAGTLMVEPT ESESQVEIDR FIDAMLAIRS EINRVAQGEW PLDDNPLVNA 900
    PHTQAELVAD WAHPYSRELA VFPAGSEHKY WPSVKRLDDV YGDRNLFCSC 950
    VPMSDYA 957
    Length:957
    Mass (Da):104,119
    Last modified:August 16, 2004 - v1
    Checksum:iCF62740108BFA2A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950851 Genomic DNA. Translation: CAG73659.1.
    RefSeqiWP_011092352.1. NC_004547.2.
    YP_048857.1. NC_004547.2.

    Genome annotation databases

    EnsemblBacteriaiCAG73659; CAG73659; ECA0745.
    GeneIDi2882290.
    KEGGieca:ECA0745.
    PATRICi20476676. VBIPecAtr54885_0743.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX950851 Genomic DNA. Translation: CAG73659.1 .
    RefSeqi WP_011092352.1. NC_004547.2.
    YP_048857.1. NC_004547.2.

    3D structure databases

    ProteinModelPortali Q6D974.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218491.ECA0745.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAG73659 ; CAG73659 ; ECA0745 .
    GeneIDi 2882290.
    KEGGi eca:ECA0745.
    PATRICi 20476676. VBIPecAtr54885_0743.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PATR218491:GJNB-769-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SCRI 1043 / ATCC BAA-672.

    Entry informationi

    Entry nameiGCSP_PECAS
    AccessioniPrimary (citable) accession number: Q6D974
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: August 16, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3