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Q6D974 (GCSP_PECAS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:ECA0745
OrganismPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica) [Complete proteome] [HAMAP]
Taxonomic identifier218491 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

Protein attributes

Sequence length957 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 957957Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227104

Amino acid modifications

Modified residue7081N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6D974 [UniParc].

Last modified August 16, 2004. Version 1.
Checksum: CF62740108BFA2A0

FASTA957104,119
        10         20         30         40         50         60 
MTQTLSQLEH DGAFIERHIG PSVSQQQHML SVVGATSLDA LIRQIVPADI QLPSPPAVGE 

        70         80         90        100        110        120 
AVTEHEALAE LKAIAGRNQR YKSYIGMGYS AVLMPPVILR NVLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLEALLNF QQVTQDLTGL DLASASLLDE ATAAAEAMAM AKRISKLKQA ERFFVADDVH 

       190        200        210        220        230        240 
PQTLDVVRTR AETFGFEIVV GKAEEALKDD AVFGVLLQQA GTTGELHDYS DLMAALKARK 

       250        260        270        280        290        300 
VVSCVASDIM ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFACR DEHKRAMPGR 

       310        320        330        340        350        360 
IIGVSRDAAG NTAFRMAMQT REQHIRREKA NSNICTSQVL LANIAGMYAV FHGPEGLKRI 

       370        380        390        400        410        420 
AGRIHRLTDI LAAGLTQGGL LLRHRSWFDT LTIEVADKDV VLSRALSFGI NLRSDLASAV 

       430        440        450        460        470        480 
GITLDEATTR EDVLALFAVL LGDDHGLDIE ALDASIAQEV ATIPAGLLRH DAILSHPVFN 

       490        500        510        520        530        540 
RYHSETEMMR YLHRLARKDL ALNQAMIPLG SCTMKLNAAA EMLPITWPEF AELHPFCPPE 

       550        560        570        580        590        600 
QALGYRQMIE QLSGWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRRYHESR NEAGRHLCLI 

       610        620        630        640        650        660 
PSSAHGTNPA SAQMAGMEVV VVACDKQGNI DLHDLREKAQ AAGEQLSCIM VTYPSTHGVY 

       670        680        690        700        710        720 
EETIREVCQI VHQYGGQVYL DGANMNAQVG ITTPGYIGAD VSHLNLHKTF CIPHGGGGPG 

       730        740        750        760        770        780 
MGPIGVKAHL APFVPGHQVV KIDGVLTEQG AVSAAPFGSA SILPISWMYI RMMGAEGLKQ 

       790        800        810        820        830        840 
ASQMAILNAN YIATRLQQAY PVLYTGRDGR VAHECILDIR PLKESTGISE MDIAKRLIDY 

       850        860        870        880        890        900 
GFHAPTMSFP VAGTLMVEPT ESESQVEIDR FIDAMLAIRS EINRVAQGEW PLDDNPLVNA 

       910        920        930        940        950 
PHTQAELVAD WAHPYSRELA VFPAGSEHKY WPSVKRLDDV YGDRNLFCSC VPMSDYA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX950851 Genomic DNA. Translation: CAG73659.1.
RefSeqYP_048857.1. NC_004547.2.

3D structure databases

ProteinModelPortalQ6D974.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218491.ECA0745.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAG73659; CAG73659; ECA0745.
GeneID2882290.
KEGGeca:ECA0745.
PATRIC20476676. VBIPecAtr54885_0743.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycPATR218491:GJNB-769-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PECAS
AccessionPrimary (citable) accession number: Q6D974
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 16, 2004
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families