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Q6D974

- GCSP_PECAS

UniProt

Q6D974 - GCSP_PECAS

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, ECA0745
Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPATR218491:GJNB-769-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:ECA0745
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000007966: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 957957Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000227104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi218491.ECA0745.

Structurei

3D structure databases

ProteinModelPortaliQ6D974.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6D974-1 [UniParc]FASTAAdd to Basket

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MTQTLSQLEH DGAFIERHIG PSVSQQQHML SVVGATSLDA LIRQIVPADI    50
QLPSPPAVGE AVTEHEALAE LKAIAGRNQR YKSYIGMGYS AVLMPPVILR 100
NVLENPGWYT AYTPYQPEVS QGRLEALLNF QQVTQDLTGL DLASASLLDE 150
ATAAAEAMAM AKRISKLKQA ERFFVADDVH PQTLDVVRTR AETFGFEIVV 200
GKAEEALKDD AVFGVLLQQA GTTGELHDYS DLMAALKARK VVSCVASDIM 250
ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFACR DEHKRAMPGR 300
IIGVSRDAAG NTAFRMAMQT REQHIRREKA NSNICTSQVL LANIAGMYAV 350
FHGPEGLKRI AGRIHRLTDI LAAGLTQGGL LLRHRSWFDT LTIEVADKDV 400
VLSRALSFGI NLRSDLASAV GITLDEATTR EDVLALFAVL LGDDHGLDIE 450
ALDASIAQEV ATIPAGLLRH DAILSHPVFN RYHSETEMMR YLHRLARKDL 500
ALNQAMIPLG SCTMKLNAAA EMLPITWPEF AELHPFCPPE QALGYRQMIE 550
QLSGWLVQLT GYDAVCMQPN SGAQGEYAGL LAIRRYHESR NEAGRHLCLI 600
PSSAHGTNPA SAQMAGMEVV VVACDKQGNI DLHDLREKAQ AAGEQLSCIM 650
VTYPSTHGVY EETIREVCQI VHQYGGQVYL DGANMNAQVG ITTPGYIGAD 700
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHQVV KIDGVLTEQG 750
AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQMAILNAN YIATRLQQAY 800
PVLYTGRDGR VAHECILDIR PLKESTGISE MDIAKRLIDY GFHAPTMSFP 850
VAGTLMVEPT ESESQVEIDR FIDAMLAIRS EINRVAQGEW PLDDNPLVNA 900
PHTQAELVAD WAHPYSRELA VFPAGSEHKY WPSVKRLDDV YGDRNLFCSC 950
VPMSDYA 957
Length:957
Mass (Da):104,119
Last modified:August 16, 2004 - v1
Checksum:iCF62740108BFA2A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG73659.1.
RefSeqiWP_011092352.1. NC_004547.2.
YP_048857.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG73659; CAG73659; ECA0745.
GeneIDi2882290.
KEGGieca:ECA0745.
PATRICi20476676. VBIPecAtr54885_0743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX950851 Genomic DNA. Translation: CAG73659.1 .
RefSeqi WP_011092352.1. NC_004547.2.
YP_048857.1. NC_004547.2.

3D structure databases

ProteinModelPortali Q6D974.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218491.ECA0745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAG73659 ; CAG73659 ; ECA0745 .
GeneIDi 2882290.
KEGGi eca:ECA0745.
PATRICi 20476676. VBIPecAtr54885_0743.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PATR218491:GJNB-769-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SCRI 1043 / ATCC BAA-672.

Entry informationi

Entry nameiGCSP_PECAS
AccessioniPrimary (citable) accession number: Q6D974
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: August 16, 2004
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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