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Protein

NAD kinase

Gene

nadK

Organism
Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73Proton acceptorUniRule annotation1
Binding sitei158NADUniRule annotation1
Binding sitei175NADUniRule annotation1
Binding sitei177NADUniRule annotation1
Binding sitei247NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 74NADUniRule annotation2
Nucleotide bindingi147 – 148NADUniRule annotation2
Nucleotide bindingi188 – 193NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:ECA0841
OrganismiPectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672) (Erwinia carotovora subsp. atroseptica)
Taxonomic identifieri218491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaePectobacterium
Proteomesi
  • UP000007966 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002296351 – 292NAD kinaseAdd BLAST292

Interactioni

Protein-protein interaction databases

STRINGi218491.ECA0841.

Structurei

3D structure databases

ProteinModelPortaliQ6D8Y0.
SMRiQ6D8Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91. Bacteria.
COG0061. LUCA.
HOGENOMiHOG000227221.
KOiK00858.
OMAiVNLGHVG.
OrthoDBiPOG091H02D1.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiView protein in InterPro
IPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiView protein in Pfam
PF01513. NAD_kinase. 1 hit.
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6D8Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPFNCIGI VGHPRHPTAL ATHEMLYHWL TEKGYSVLIE QQIARELNLK
60 70 80 90 100
DAPTGSLADI GQQADLAVVV GGDGNMLGAA RVLSRYDIKV IGVNRGNLGF
110 120 130 140 150
LTDLDPDHAQ QQLSDVLDGH YLSEQRFMLE AHVCRTNQPD SISTAINEVV
160 170 180 190 200
LHPGKVAHMI EFEVYIDDRF AFSQRSDGLI IATPTGSTAY SLSAGGPILT
210 220 230 240 250
PSLEAIALVP MFPHTLSARP LVINSSSTIR LKFSCITNDL EISCDSQIAL
260 270 280 290
PVQEGEEVLI RRSEHHLNLI HPKNYSYFNT LSSKLGWSKK LF
Length:292
Mass (Da):32,167
Last modified:August 16, 2004 - v1
Checksum:iE318787D330EAFD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX950851 Genomic DNA. Translation: CAG73754.1.
RefSeqiWP_011092446.1. NC_004547.2.

Genome annotation databases

EnsemblBacteriaiCAG73754; CAG73754; ECA0841.
KEGGieca:ECA0841.
PATRICifig|218491.5.peg.842.

Similar proteinsi

Entry informationi

Entry nameiNADK_PECAS
AccessioniPrimary (citable) accession number: Q6D8Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: August 16, 2004
Last modified: August 30, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families