Reviewed, UniProtKB/Swiss-Prot Q6D8U8 (HEM6_ERWCT)

Names and origin

Protein names

Recommended name:
    Coproporphyrinogen 3 oxidase, aerobic
    EC=1.3.3.3
Alternative name(s):
    Coproporphyrinogen III oxidase, aerobic
      Short name=Coproporphyrinogenase
      Short name=Coprogen oxidase

Gene names

Name:	hemF
Ordered Locus Names:	ECA0874

Organism

Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) [Complete proteome] [HAMAP]

Taxonomic identifier

29471 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Coproporphyrinogen-III + O(2) + 2 H(+) = protoporphyrinogen-IX + 2 CO(2) + 2 H(2)O.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen III (O2 route): step 1/1.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the aerobic coproporphyrinogen III oxidase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: HAMAP
Molecular function	coproporphyrinogen oxidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Coproporphyrinogen 3 oxidase, aerobic		PRO_0000109897

Sequences

	Sequence		Length	Mass (Da)
	Q6D8U8-1 [UniParc]. Last modified August 16, 2004. Version 1. Checksum: 9EA389EDDE38B75F	FASTA	310	35,241
	10 20 30 40 50 60 MSDINAVKHF LLSLQKDICQ QLAAIDGGAD FAEDEWQRAE GGGGCSRVLS GGRIFERTGV 70 80 90 100 110 120 NFSHVTGKSL PPSASTHRPD LAGRSFQAMG VSLVIHPLSP YIPTSHANVR LFVAEKPGEE 130 140 150 160 170 180 PVWWFGGGFD LTPYYGFKED AVHWHQTAHD LCQPFGDDVY PRYKKWCDDY FFLKHRNEAR 190 200 210 220 230 240 GIGGLFFDDL NEPDFATSFA FIRAVGNGFL DGYLPIVERR KDLAWGERER DFQLYRRGRY 250 260 270 280 290 300 VEFNLIWDRG TLFGLQSGGR TESILMSMPP LARWEYQHQP EPDSPEAALY RDFLPARDWL 310 AESNTHNKEA

References

[1]

"Genome sequence of the enterobacterial phytopathogen Erwinia carotovora subsp. atroseptica and characterization of virulence factors." Bell K.S., Sebaihia M., Pritchard L., Holden M.T.G., Hyman L.J., Holeva M.C., Thomson N.R., Bentley S.D., Churcher L.J.C., Mungall K., Atkin R., Bason N., Brooks K., Chillingworth T., Clark K., Doggett J., Fraser A., Hance Z. , Hauser H., Jagels K., Moule S., Norbertczak H., Ormond D., Price C., Quail M.A., Sanders M., Walker D., Whitehead S., Salmond G.P.C., Birch P.R.J., Parkhill J., Toth I.K. Proc. Natl. Acad. Sci. U.S.A. 101:11105-11110(2004) [PubMed: 15263089] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SCRI 1043 / ATCC BAA-672.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX950851 Genomic DNA. Translation: CAG73786.1.
RefSeq	YP_048983.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2885670.
GenomeReviews	Gene locus ECA0874 in contig BX950851_GR.
KEGG	eca:ECA0874.
NMPDR	fig|218491.3.peg.3719.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q6D8U8.
Enzyme and pathway databases
BioCyc	ECAR218491:ECA0874-MON.
Family and domain databases
HAMAP	MF_00333. [Tree]
InterPro	IPR001260. Coprogen_oxidas. [Graphical view]
Gene3D	G3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
PANTHER	PTHR10755. Coprogen_oxidas. 1 hit.
Pfam	PF01218. Coprogen_oxidas. 1 hit. [Graphical view]
PIRSF	PIRSF000166. Coproporphyri_ox. 1 hit.
PRINTS	PR00073. COPRGNOXDASE.
PROSITE	PS01021. COPROGEN_OXIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEM6_ERWCT

Accession

Primary (citable) accession number: Q6D8U8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	August 16, 2004
Last modified:	November 4, 2008
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)